PNNL

Abstract

In the last decade, magnetic nanoparticles (MNPs), especially superparamagnetic iron oxide nanoparticles (SPIONs), have immensely promoted the advancement of diagnostics and therenostic in the biomedical field. SPIONs with unique properties of SPIONs-core and the functional Au-shell in consortium (SPIONS/Au core/shell, or CS), has a wide range of biomedical applications including but not limited to magnetic resonance imaging (MRI), dual modality MRI/computed tomography (CT), photo-induced and magnetic fluid hyperthermia (MFH), drug delivery, biosensor, and bio-separation. Researchers have constantly made an effort to develop the synthesis strategies for size control and surface modifications in order to achieve the desired properties of these CSs for applications in in vitro and in vivo studies. This review highlights on recent developments in the synthesis and biomedical applications of SPIONs/Au CSs including ?-Fe2O3/Au (maghemite), Fe3O4/Au (magnetite), and MFe2O4/Au [M=divalent metal ions] in the past seven years. More importantly, recent trend of SPIONs/Au in relation to the biochemical industry is surveyed. Finally, we outline the developmental need of SPIONs/Au with a perspective in material synthesis and its novel application in disease diagnosis and treat in the near future.