Trifluralin (TF) is a lipophilic, pre-emergent herbicide widely used in agriculture and known to bioconcentrate in fish. We have characterized the accumulation of TF in rainbow trout under a variety of experimental conditions. Our approach has been to use static water exposure systems and intra-vascular dosing in combination with clearance-volume pharmacokinetic (CV-PK) models to obtain quantitative estimates of uptake clearance, apparent volume of distribution and elimination due to xenobiotic metabolism. This paper will briefly discuss pertinent physicochemical data for TF and review the toxicokinetics of TF in rainbow trout. Emphasis will be placed on physiological interpretations of TF model parameters and practical aspects of modeling TF toxicokinetics with CV-PK models.
Revised: May 12, 2003 |
Published: October 13, 1999
Citation
Schultz I.R., and W.L. Hayton. 1999.Predicting the Toxicokinetics of Trifluralin in Rainbow Trout Using Clearance-Volume Pharmacokinetic Models. In Xenobiotics in Fish, edited by David J.Smith, William H.Gingerich, Maria G.Barker, VIII, 133-148. New York, New York:Kluwer Academic/Plenum Publishers. PNWD-SA-5233.