In this chapter, we summarize recent work in our laboratory on the development of sensitive portable analytical systems for use in on-site detection of exposure to organophosphate (OP) pesticides and chemical nerve agents. These systems are based on various nanomaterials functioning as transducers; recognition agents or labels and various elelectrochemical/immunoassay techniques. The studied nanomaterials included functionalized carbon nanotubes (CNT), zirconia nanoparticles (NPs) and quantum dots (QDs). Three biomarkers e.g. the free OPs, metabolites of OPs and protein-OP adducts in biological matrices have been employed for biomonitoring of OP exposure with our developed system. It has been found that the nanomaterial-based portable analytical systems have high sensitivity for the detection of the biomarkers, which suggest that these technologies offer great promise for the rapid and on-site detection and evaluation of OP exposure.
Revised: June 4, 2010 |
Published: December 1, 2009
Citation
Lin Y., J. Wang, G. Liu, and C. Timchalk. 2009.Portable Analytical Systems for On-Site Diagnosis of Exposure to Pesticides and Nerve Agents. In Nanoscience and Nanotechnology for Chemical and Biological Defense, ACS Sympoisum Series, edited by R. Nagarajan, W. Zukas, T. A. Hatton, S. Lee. 85-98. Dc:Oxford University Press.PNNL-SA-59141.