The lifespan of AIDS patients has increased as a result of aggressive antiretroviral therapy, and the incidences of the AIDS-defining cancers, Hodgkin’s lymphoma and Kaposi sarcoma, are declining, Still, the increased longevity of AIDS patients is now associated with increased incidence of other cancers, including Hodgkin’s lymphoma (HL). In order to determine if we could identify biomarkers for the early detection of HL, we undertook an accurate mass and elution time tag proteomics analysis of individual plasma samples from AIDS patients without HL (n=14) and with HL (n=22). This analysis identified 33 proteins, included C-reactive protein and three serum amyloid proteins, that were statistically (p
Revised: December 22, 2011 |
Published: December 16, 2011
Citation
Varnum S.M., B.M. Webb-Robertson, N. Hessol, R.D. Smith, and R.C. Zangar. 2011.Plasma Biomarkers for Detecting Hodgkin's Lymphoma in HIV Patients.PLoS One 6, no. 12:Article No. e29263.PNNL-SA-81553.doi:10.1371/journal.pone.0029263