It has become increasingly evident from reports in the literature that there are many confounding factors that are capable of modulating radiation induced non-targeted responses such as the bystander effect and the adaptive response. In this paper we examine recent data that suggest that the observation of non-targeted responses may not be universally observable for differing radiation qualities. We have conducted a study of the adaptive response following low LET exposures for human colon carcinoma cells and failed to observe adaption for the endpoints of clonogenic survival or micronucleus formation.
Revised: April 7, 2011 |
Published: January 6, 2011
Citation
Sowa M.B., W. Goetz, J.E. Baulch, A.J. Lewis, and W.F. Morgan. 2011.No Evidence for a Low Linear Energy Transfer Adaptive Response in Irradiated RKO Cells.Radiation Protection Dosimetry 143, no. 2-4:311-314.PNNL-SA-70739.doi:10.1093/rpd/ncq487