Abstract In this article, we describe some current multiscale modeling issues in computational biomechanics from the perspective of the musculoskeletal and respiratory systems and mechanotransduction. First, we outline the necessity of multiscale simulations in these biological systems. Then we summarize challenges inherent to multiscale biomechanics modeling, regardless of the subdiscipline, followed by computational challenges that are system-specific. We discuss some of the current tools that have been utilized to aid research in multiscale mechanics simulations, and the priorities to further the field of multiscale biomechanics computation.
Revised: August 9, 2010 |
Published: May 1, 2009
Citation
Tawhai M., J. Bischoff, D.R. Einstein, A. Erdemir, T. Guess, and J. Reinbolt. 2009.Multiscale Modeling in Computational Biomechanics: Determining Computational Priorities and Addressing Current Challenges.IEEE Engineering in Medicine and Biology Magazine 28, no. 3:41-9.PNNL-SA-58290.