Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was
developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Revised: November 26, 2012 |
Published: November 1, 2012
Citation
Guo C., B.P. Knox, Y.M. Chiang, H. Lo, J.F. Sanchez, K. Lee, and B.R. Oakley, et al. 2012.Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin.Organic Letters 14, no. 22:5684-5687.PNNL-SA-89040.doi:10.1021/ol302682z