December 1, 2014
Journal Article

Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress

Abstract

Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on progesterone and estradiol-17b accumulation by rat ovaries ex vivo and (2) to identify the locus/loci whereby GNPs modulate steroidogenesis via multiple-reference gene quantitative real-time RT-PCR. Regression analyses indicated a positive relationship between both Star (p

Revised: December 29, 2014 | Published: December 1, 2014

Citation

Larson J.K., M.J. Carvan, J.G. Teeguarden, G. Watanabe, K. Taya, E. Krystofiak, and R.J. Hutz. 2014. Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress. Nanotoxicology 8, no. 8:856-66. PNNL-SA-101177. doi:10.3109/17435390.2013.837208