We report that antibodies can be loaded in functionalized mesoporous silica (FMS) with super-high density to provide long-lasting local release at a given site. Preliminary data indicate that FMS-antibody injected directly into a mouse melanoma induces a greater inhibition of tumor growth than seen in various controls, including the antibody injected intraperitoneally. Our findings introduce a novel approach for local delivery of therapeutically active proteins to tumors and potentially, other diseases.
Revised: June 28, 2010 |
Published: May 26, 2010
Citation
Lei C., P. Liu, B. Chen, Y. Mao, H.E. Engelmann, Y. Shin, and J. Jaffar, et al. 2010.Local Release of Highly Loaded Antibodies from Functionalized Nanoporous Support for Cancer Immunotherapy.Journal of the American Chemical Society 132, no. 20:6906-6907.PNNL-SA-71656.