EXTERNAL ACCUMULATION OF IONS FOR FTICR DETECTION The need for higher mass accuracy and precision in analysis of e.g. biological compounds is now commonly addressed by storing charged particles in an ion trap using a superposition of the constant static magnetic and spatially inhomogeneous electric fields, often referred to as Penning trap. The Penning trap has been successfully employed in Fourier Transform Ion Cyclotron Resonance (FTICR) MS instrumentation. Since its inception in 1973,1 FTICR has been the subject of multiple reviews,2-9 several journal issues10,11 and books12,13 that give a full-range technical introduction to both single ion and more populated ion clouds (a group of ions who’s motion is to some extent influenced by the other ions in the cloud) behavior in combined magnetic and electric fields, subsequent signal processing, and technique applications. Principles and design of geometric and electrical configurations of ICR traps have been also reviewed.14 The reader is referred to these publications for more information. Herein, we will give a brief overview of the ion cloud behavior in the superimposed magnetic and electric fields, with an emphasis on ICR trap design, and highlight FTICR performance improvements due to accumulation of ions in another trap external to FTICR.
Revised: May 10, 2011 |
Published: May 25, 2010
Citation
Belov M.E., Y.M. Ibrahim, and R.D. Smith. 2010.Ion Accumulation Approaches for Increasing Sensitivity and Dynamic Range in the Analysis of Complex Samples. In Practical Aspects of Trapped Ion Mass Spectrometry: Theory and Instrumentation, edited by RE March and JFJ Todd. 401-432. Boca Raton, Florida:CRC Press.PNNL-SA-60908.