Measuring the exposome remains a challenge due to the range and number of anthropogenic molecules that are encountered in our daily lives, as well as the complex systemic responses to these exposures. One option for improving the coverage, dynamic range and throughput of measurements is to incorporate ion mobility spectrometry (IMS) into current mass spectrometry (MS)-based analytical methods. In this perspective, we briefly review the state-of-the-art in measuring the exposome, and discuss the potential use for IMS-MS and the physico-chemical property of collisional cross section in both exposure assessment and molecular identification.
Revised: April 10, 2020 |
Published: January 9, 2017
Citation
Metz T.O., E.M. Baker, E.L. Schymanski, R.S. Renslow, D.G. Thomas, T.J. Causon, and I.K. Webb, et al. 2017.Integrating Ion Mobility Spectrometry into Mass Spectrometry-based Exposome Measurements: What Can It Add and How Far Can It Go?.Bioanalysis 9, no. 1:81-98.PNNL-SA-121158.doi:10.4155/bio-2016-0244