June 26, 2025
Journal Article

Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors

Abstract

Progression to type 1 diabetes (T1D) is associated with genetic factors, the presence of autoantibodies, and a decline in ??cell insulin secretion in response to glucose. Very little is known regarding the molecular changes that occur in human insulin-secreting ??cells prior to the onset of T1D. Herein, we applied an unbiased proteomics approach to identify changes in proteins and potential mechanisms of islet dysfunction in islet autoantibody-positive organ donors with pre-symptomatic stage 1 T1D (HbA1c = 6). We aimed to identify islet pathways indicative of ß-cell dysfunction.

Published: June 26, 2025

Citation

Swensen A.C., P.D. Piehowski, J. Chen, X. Chan, S.S. Kelly, V.A. Petyuk, and R.J. Moore, et al. 2025. Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors. Diabetologia 68, no. 7:1463–1475. PNNL-SA-203684. doi:10.1007/s00125-025-06417-3

Research topics

Integrative Omics