October 29, 2013
Journal Article

Hydration, Ionic Valence and Cross-Linking Propensities of Cations
Determine the Stability of Lipopolysaccharide (LPS) Membranes

Abstract

The supra-molecular structure of LPS aggregates governs outer membrane permeability and activation of the host immune response during Gram-negative bacterial infections. Molecular dynamics simulations unveil at atomic resolution 10 the subtle balance between cation hydration and cross-link ability in modulating phase transitions of LPS membranes.

Revised: February 6, 2014 | Published: October 29, 2013

Citation

Nascimento A., F.J. Pontes, R.D. Lins, and T.A. Soares. 2013. "Hydration, Ionic Valence and Cross-Linking Propensities of Cations Determine the Stability of Lipopolysaccharide (LPS) Membranes." Chemical Communications 50, no. 2:231-233. doi:10.1039/C3CC46918B