Bacterial pathogen-secreted proteases may play a key role in inhibiting a potentially widespread host-pathogen interaction. Activity-based protein profiling enabled the identification of a major Vibrio cholerae serine protease that limits the ability of a host-derived intestinal lectin to bind to the bacterial pathogen in vivo.
Revised: March 4, 2020 |
Published: February 22, 2016
Citation
Wright A.T. 2016.HOST-PATHOGEN INTERACTIONS: A cholera surveillance system.Nature Chemical Biology 12, no. 4:203-204.PNNL-SA-115724.doi:10.1038/nchembio.2039