Phospholamban (PLN) isan integralmembrane protein that inhibits the sarcoplasmic reticulumCa2รพ-ATPase, thereby regulating muscle contractility.We report a combined electrochemical and theoretical study demonstrating that the pentameric PLN
does not possess channel activity for conducting chloride or calciumions across the lipidmembrane. This suggests that the pentameric configuration of PLN primarily serves as a storage form for the regulatory function of muscle relaxation by the PLN monomer.
Revised: May 19, 2010 |
Published: May 20, 2009
Citation
Becucci L., A. Cembran, C.B. Karim, D.D. Thomas, R. Guidelli, J. Gao, and G. Veglia. 2009.On the Function of Pentameric Phospholamban: Ion Channel or Storage Form?.Biophysical Journal 96, no. 10:L60-L62. doi:10.1016/j.bpj.2009.03.013