FT-ICR MS achieves the highest resolution and best mass measurement accuracy of any mass spectrometry method. These remarkable achievements are due to several factors, including multi-channel detection, measurement of frequency, magnetic field stability, and dependence of cyclotron frequency on only the magnetic field and ion mass to charge ratio, not on ion kinetic energy and other factors. Significant advances in magnet technology, instrument design and construction continue to enhance the capabilities of FT-ICR MS. FT-ICR has been applied to a variety of analytical challenges and is particularly suited to the analysis of complex mixtures and in applications where high resolution and mass measurement accuracy are critical analytical parameters.
Revised: September 29, 2016 |
Published: March 28, 2014
Citation
Robinson E.W. 2014.Fourier-Transform ion cyclotron mass spectrometry (FT-ICR MS). In Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition, edited by J Lindon. 714-719. Cambridge, Massachusetts:Academic Press.PNNL-SA-69150.doi:10.1016/B978-0-12-374413-5.00177-9