June 15, 2001
Journal Article

DNA-XPA Interactions: A 31P NMR Study of dCCAATAACC Association With the Minimal DNA-Binding Domain (M98-F219) of the Nucleotide Excision Repair Protein XPA

Abstract

XPA is a central protein component of nucleotide excision repair (NER), playing an important role in recognizing DNA damage and orchestrating other proteins into position to remove the damage. Recent chemical shift mapping experiments with the minimal DNA-binding domain of XPA (XPA-MBD: M98-F219) suggests that a basic cleft located in the loop-rich subdomain plays a role in DNA binding.

Revised: July 27, 2001 | Published: June 15, 2001

Citation

Buchko G.W., C. Tung, K. Mcateer, N.G. Isern, L.D. Spicer, and M.A. Kennedy. 2001. DNA-XPA Interactions: A 31P NMR Study of dCCAATAACC Association With the Minimal DNA-Binding Domain (M98-F219) of the Nucleotide Excision Repair Protein XPA. Nucleic Acids Research 29, no. 12:2635-2643. PNNL-SA-34180.