Recent studies have suggested that there may be a relationship between the levels of drug-metabolizing cytochromes P450 (P450) and cholesterol regulation. In this study, we examined the effects of in vivo treatment with a variety of structurally distinct P450 inducers on rat hepatic cholesterol levels. We found that these agents decreased levels of cholesterol and cholesterol esters in microsomes, but generally increased levels of these lipids in crude membrane fractions pooled from the rest of the liver. These results suggest that P450 inducers alter cholesterol processing or trafficking within the cell, possibly by altering proteins that are co-regulated by the same transcription factors as the P450s
Revised: July 22, 2010 |
Published: July 1, 2005
Citation
Zangar R.C. 2005.Alterations in hepatic cholesterol levels in response to drugs that induce cytochrome P450 3A23.International Journal of Pharmacology 1, no. 2:172-179. PNWD-SA-6374.