Biomedical Scientist
Biomedical Scientist

Biography

Vince Gerbasi is a microbiologist in the Exposure and Pathogen Biology group at PNNL. His research uses high-resolution mass spectrometry to study infectious diseases and host responses.   

Education

  • Postdoctoral Fellowship, Molecular Biosciences, Northwestern University, 2010
  • PhD in Microbiology and Immunology, Vanderbilt University Medical School, 2007
  • BS in Microbiology, Washington State University, 2002

Publications

2020

  • Link AJ, Niu X, Weaver CM, Jennings JL, Duncan DT, McAfee KJ, Sammons M, Gerbasi VR, Farley AR, Fleischer TC, Browne CM, Samir P, Galassie A, Boone B. Targeted Identification of Protein Interactions in Protein Translation. 2020 Proteomics PMID: 32027465
  • Winer B, Edgel KA, Zou X, Sellau J, Hadiwidjojo S, Garver LS, McDonough CE, Kelleher NL, Thomas PM, Villasante E, Ploss A, Gerbasi VR.Identification of Plasmodium falciparum Proteoforms from Liver Stage Models. 2020 Malaria J.19:10.

2019

  • Cawlfield A, Genito CJ, Beck Z, Bergmann-Leitner ES, Bitzer AA, Soto K, Zou X, Hadiwidjojo SH, Gerbasi RV, Mullins AB, Noe A, Waters NC, Alving CR, Matyas GR, Dutta S. (2019) Safety, Toxicity, and immunogenicity of a malaria vaccine based on the circumsporozoite protein (FMP013) with the adjuvant army liposome formulation containing QS21(ALFQ). Vaccine, Jun 27;37(29):3793-3803.
  • Des Soye BJ, Gerbasi VR, Thomas PM, Kelleher NL, Jewett MC. A Highly Productive, One-Pot Cell-free Protein Synthesis Platform Based on Genomically Recoded Escherichia Coli.  2019 Cell Chem Bio. Nov 6; S2451-9456 (19)30553-8.
  • Melani RD, Srzentić K, Gerbasi VR, McGee JP, Huguet R, Fornelli L, and Kelleher NL. Direct Measurement of Light and Heavy Antibody Chains Using FAIMS and Middle-Down Mass Spectrometry. (2019) mAbs. Nov-Dec; 11(8): 1351-1357.

2018

  • Gerbasi VR, Browne CM, Samir P, Shen B, Sun M, Hazelbaker DZ, Galassie AC, Frank J, Link AJ. (2018) Critical role of Saccharomyces cerevisiae Asc1p in translational initiation at elevated temperatures. Proteomics, Oct 4:e1800208. doi: 10.1002/pmic.201800208.

2017

2015

  • Alajem A, Biran A, Harikumar A, Sailaja BS, Aaronson Y, Livyatan I, Nissim-Rafinia M, Sommer AG, Mostoslavsky G, Gerbasi VR, Golden DE, Datta A, Sze SK, Meshorer E. (2015). Differential association of chromatin proteins identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation. Cell Rep (12):2019-31.
  • Valdivia HO, Reis-Cunha JL, Rodriguez-Luiz GF, Baptista RP, Baldeviano GC, Gerbasi RV, Dobson DE, Pratlong F, Bastien P, Lescano AG, Beverley SM, Batholomeu DC (2015) Comparative Genomic Analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis. BMC Genomics (16): 715.

2013

  • McCoy, M.E., Golden, H.E., Doll, T.A., Yang, Y., Kaba, S.A., Zou, X., Gerbasi, V.R., Burkhard, P., and Lanar, D.E. (2013) Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine. Malaria Journal (1): 136.
  • Zou, X., House, BL., Zyzak, MD., Richie, TL., Gerbasi V.R. (2013) Towards an Optimized Inhibition of Liver Stage Development Assay (ILSDA) for Plasmodium falciparum. Malaria Journal (1): 394.

2012

  • Siedman, D., Johnson, D., Gerbasi V., Golden D., Orlando, R., Hajduk, S. (2012).  A Mitochondrial membrane complex that contains proteins necessary for tRNA import in Trypanosoma brucei. J Biol Chem 287(12):8892-903.

2003-2011

  • Gerbasi, V., Lutsenko, S., and Lewis, E. J. (2003). A mutation in the ATP7B copper transporter causes reduced dopamine beta-hydroxylase and norepinephrine in mouse adrenal. Neurochem Res 28, 867-873.
  • Rychlik, J. L., Gerbasi, V., and Lewis, E. J. (2003). The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. J Biol Chem 278, 49652-49660.
  • Gerbasi, V. R., Weaver, C. M., Hill, S., Friedman, D. B., and Link, A. J. (2004). Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression. Mol Cell Biol 24, 8276-8287.
  • Link, A. J., Fleischer, T. C., Weaver, C. M., Gerbasi, V. R., and Jennings, J. L. (2005). Purifying protein complexes for mass spectrometry: applications to protein translation. Methods 35, 274-290.
  • Gerbasi, V. R., and Link, A. J. (2007). The myotonic dystrophy type-2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation. Molecular Cellular Proteomics 6, 1049-1058.
  • Golden, D.E., Gerbasi, V.R., and Sontheimer, E.J. (2008).  An inside job for siRNAs. Mol Cell 31, 309-312.
  • Gerbasi, V.R., Golden, D.E., Hurtado, S.L. and Sontheimer, E.J. (2010).  Proteomic identification of Drosophila siRNA-associated factors. Molecular Cellular Proteomics 9, 1866-72.
  • Gerbasi, V.R., Preall, J., Golden, D.E., Cummins, T., Powell, D.W., and Sontheimer, E.J.  (2011) Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis.  PNAS 108, 3204-9.