The global demand for xenon, a noble gas with applications in electronics, lighting, and the medical industry is expected to rise significantly over the next decades. However, the low abundance of xenon in earth's atmosphere and costly cryogenic distillation process that is used to obtain xenon commercially via air separation limited the scale of applications of xenon. A physisorption-based separation using porous materials may be a viable and cost-effective alternative to cryogenic distillation. In particular, open framework structures consists of organic, inorganic and metal organic materials have shown to be very promising for selective Xe removal at room temperature. We at PNNL have demonstrated, materials with small pore geometry are selective for Xe over other complex gas mixtures relevant to nuclear re-processing and from air. Similarly, materials with large pore consist of small and large pores relevant to Xenon recycle and re-use from medical anaesthetic gas mixture and semiconductor applications. Finally materials with high surface area are important for Xenon storage applications.