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Fundamental and Computational Sciences Directorate

Staff information

Tong Zhang

Proteomics
Chemist
Pacific Northwest National Laboratory
PO Box 999
MSIN:
Richland, WA 99352

PNNL Publications

2023

  • Day J.J., T. Zhang, A. Hamsath, D.L. Neill, S. Xu, W. Qian, and M. Xian. 2023. "A Chemical Approach for the Specific Generation of Cysteine Sulfinylation." Tetrahedron Letters 114. PNNL-SA-180543. doi:10.1016/j.tetlet.2022.154284
  • Day N.J., T. Zhang, M.J. Gaffrey, B.D. Thrall, and W. Qian. 2023. "Assessment of the Biological Impact of Engineered Nanomaterials Using Mass Spectrometry-based MultiOmics Approaches." In Impact of Engineered Nanomaterials in Genomics and Epigenomics, edited by S.C. Sahu. 331 - 354. Hoboken, New Jersey:John Wiley & Sons. PNNL-SA-177428. doi:10.1002/9781119896258.ch15
  • Li X., A.E. Gluth, T. Zhang, and W. Qian. 2023. "Thiol Redox Proteomics: Characterization of Thiol-based Post-Translational Modifications." Proteomics 23, no. 13-14; Special Issue: Reviews 2:Art. No. 2200194. PNNL-SA-193502. doi:10.1002/pmic.202200194

2022

  • Day N.J., T. Zhang, M.J. Gaffrey, R. Zhao, T.L. Fillmore, R.J. Moore, and G. Rodney, et al. 2022. "A Deep Redox Proteome Profiling Workflow and Its Application to Skeletal Muscle of a Duchenne Muscular Dystrophy Model." Free Radical Biology & Medicine 193, no. Part 1:373-384. PNNL-SA-156410. doi:10.1016/j.freeradbiomed.2022.10.300
  • Li X., T. Zhang, N.J. Day, S. Feng, M.J. Gaffrey, and W. Qian. 2022. "Defining the S-glutathionylation Proteome by Biochemical and Mass Spectrometric Approaches." Antioxidants 11, no. 11:Art. No. 2272. PNNL-SA-179617. doi:10.3390/antiox11112272
  • Zhang T., N.J. Day, M.J. Gaffrey, K.K. Weitz, I.K. Attah, P. Mimche, and R. Paine III, et al. 2022. "Regulation of hyperoxia-induced neonatal lung injury via post-translational cysteine redox modifications." Redox Biology 55. PNNL-SA-176815. doi:10.1016/j.redox.2022.102405

2021

  • Cao X., X. Pan, S.P. Couvillion, T. Zhang, C. Tamez, L.M. Bramer, and J. White, et al. 2021. "Fate, cytotoxicity and cellular metabolomic impact of ingested nanoscale carbon dots using simulated digestion and a triculture small intestinal epithelial model." NanoImpact 23. PNNL-SA-166081. doi:10.1016/j.impact.2021.100349
  • Martin K.D., T. Zhang, T. Lin, A.N. Habowski, R. Zhao, C. Tsai, and W.B. Chrisler, et al. 2021. "Facile one-pot nanoproteomics for label-free proteome profiling of 50-1000 mammalian cells." Journal of Proteome Research 20, no. 9:4452-4461. PNNL-SA-160823. doi:10.1021/acs.jproteome.1c00403
  • Xu Z., C. Pan, X. Li, N. Hao, T. Zhang, M.J. Gaffrey, and Y. Pu, et al. 2021. "Enhancement of Polyhydroxyalkanoate Production by Co-feeding Lignin Derivatives with Glycerol in Pseudomonas putida KT2440." Biotechnology for Biofuels 14, no. 1:Article No. 11. PNNL-SA-157585. doi:10.1186/s13068-020-01861-2
  • Zhang T., M.J. Gaffrey, X. Li, and W. Qian. 2021. "Characterization of cellular oxidative stress response by stoichiometric redox proteomics." American Journal of Physiology. Cell Physiology 320, no. 2:C182-C194. PNNL-SA-151503. doi:10.1152/ajpcell.00040.2020

2020

  • Cao X., T. Zhang, G.M. Deloid, M.J. Gaffrey, K.K. Weitz, B.D. Thrall, and W. Qian, et al. 2020. "Cytotoxicity and cellular proteome impact of cellulose nanocrystals using simulated digestion and an in vitro small intestinal epithelium cellular model." NanoImpact 20. PNNL-SA-157451. doi:10.1016/j.impact.2020.100269
  • Cao X., T. Zhang, G.M. DeLoid, M.J. Gaffrey, K.K. Weitz, B.D. Thrall, and W. Qian, et al. 2020. "Evaluation of the cytotoxic and cellular proteome impacts of food-grade TiO2 (E171) using simulated gastrointestinal digestions and a tri-culture small intestinal epithelial model." NanoImpact 17. PNNL-SA-147195. doi:10.1016/j.impact.2019.100202
  • Chiao Y., H. Zhang, M. Sweetwyne, J. Whitson, Y. Ting, N. Basisty, and L. Pino, et al. 2020. "Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice." eLife 9. PNNL-SA-150324. doi:10.1101/2020.01.02.893008
  • Duan J., T. Zhang, M.J. Gaffrey, K.K. Weitz, R.J. Moore, X. Li, and M. Xian, et al. 2020. "Stochiometric Quantification of the Thiol Redox Proteome of Macrophages Reveals Subcellular Compartmentalization and Susceptibility to Oxidative Perturbations." Redox Biology 36. PNNL-SA-153520. doi:10.1016/j.redox.2020.101649
  • Martin K.D., T. Zhang, P. Zhang, W.B. Chrisler, T.L. Fillmore, F. Liu, and T. Liu, et al. 2020. "Carrier-assisted One-pot Sample Preparation for Targeted Proteomics Analysis of Small Numbers of Human Cells." Journal of Visualized Experiments (JoVE). PNNL-SA-153959. doi:10.3791/61797
  • Wang X., A.C. Swensen, T. Zhang, P.D. Piehowski, M.J. Gaffrey, M.E. Monroe, and Y. Zhu, et al. 2020. "Accurate Identification of Deamidation and Citrullination from Global Shotgun Proteomics Data Using a Dual-search Delta Score Strategy." Journal of Proteome Research 19, no. 4:1863-1872. PNNL-SA-149222. doi:10.1021/acs.jproteome.9b00766
  • Zhang T., M.J. Gaffrey, D.G. Thomas, T.J. Weber, B.M. Hess, K.K. Weitz, and P.D. Piehowski, et al. 2020. "A proteome-wide assessment of the oxidative stress paradigm for metal and metal-oxide nanomaterials in human macrophages." NanoImpact 17. PNNL-SA-147217. doi:10.1016/j.impact.2019.100194
  • Zhang T., M.J. Gaffrey, M.E. Monroe, D.G. Thomas, K.K. Weitz, P.D. Piehowski, and V.A. Petyuk, et al. 2020. "Block design with common reference samples enables robust large-scale label-free quantitative proteome profiling." Journal of Proteome Research 19, no. 7:2863-2872. PNNL-SA-151164. doi:10.1021/acs.jproteome.0c00310

2019

  • Zhang P., M.J. Gaffrey, Y. Zhu, W.B. Chrisler, T.L. Fillmore, L. Yi, and C.D. Nicora, et al. 2019. "Carrier-assisted single-tube processing approach for targeted proteomics analysis of low numbers of mammalian cells." Analytical Chemistry 91, no. 2:1441-1451. PNNL-SA-138130. doi:10.1021/acs.analchem.8b04258

2018

  • Zhang T., M.J. Gaffrey, B.D. Thrall, and W. Qian. 2018. "Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials." Analytical and Bioanalytical Chemistry 410, no. 24:6067-6077. PNNL-SA-133275. doi:10.1007/s00216-018-1168-6

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