Staff information

Education and Credentials

• Ph.D., physics, University of Utah
• BS, physics, Arizona State University

Affiliations and Professional Service

• American Physical Society
• American Physiological Society
• American Association for the Advancement of Science

PNNL Publications

2024

• Jacob R.E., M.S. Prowant, and C.A. Hutchinson. 2024. "Development and Testing of Coarse-grained Models for Ultrasonic Simulations of Cast Austenitic Stainless Steel." Ultrasonics 136. PNNL-SA-184732. doi:10.1016/j.ultras.2023.107157

2023

• Sun H., P. Ramuhalli, and R.E. Jacob. 2023. "Machine Learning for Ultrasonic Nondestructive Examination of Welding Defects: A Systematic Review." Ultrasonics 127. PNNL-SA-169657. doi:10.1016/j.ultras.2022.106854

2022

• Jacob R.E., M.S. Prowant, M.S. Hughes, and A.A. Diaz. 2022. Modeling and Simulation of Austenitic Welds and Coarse-grained Specimens: Part II. PNNL-32702. Richland, WA: Pacific Northwest National Laboratory. Modeling and Simulation of Austenitic Welds and Coarse-grained Specimens: Part II

2017

• Ramuhalli P., R.E. Jacob, P.J. MacFarlan, and A.M. Casella. 2017. "Microstructural Characterization of Irradiated U0.7ZrH1.6 Using Ultrasonic Techniques." In Transactions of the American Nuclear Society (ANS 2017), June 11-15, 2017, San Francisco, CA, 116, 361-364. La Grange Park, Illinois:American Nuclear Society. PNNL-SA-123536.

2016

• Asgharian B., O. Price, S. Kabilan, R.E. Jacob, D.R. Einstein, A.P. Kuprat, and R.A. Corley. 2016. "Development of a Zealand white rabbit deposition model to study inhalation anthrax." Inhalation Toxicology 28, no. 2:80-88. PNNL-SA-121795. doi:10.3109/08958378.2016.1140850
• Colby S.M., S. Kabilan, R.E. Jacob, A.P. Kuprat, D.R. Einstein, and R.A. Corley. 2016. "Comparison of realistic and idealized breathing patterns in computational models of airflow and vapor dosimetry in the rodent upper respiratory tract." Inhalation Toxicology 28, no. 4:192-202. PNNL-SA-121794. doi:10.3109/08958378.2016.1150367
• Kabilan S., S.R. Suffield, K.P. Recknagle, R.E. Jacob, D.R. Einstein, A.P. Kuprat, and J.P. Carson, et al. 2016. "Computational Fluid Dynamics Modeling of Bacillus anthracis Spore Deposition in Rabbit and Human Respiratory Airways." Journal of Aerosol Science 99. PNNL-SA-108616. doi:10.1016/j.jaerosci.2016.01.011
• Prowant M.S., K.M. Denslow, T.L. Moran, R.E. Jacob, T.S. Hartman, S.L. Crawford, and R. Mathews, et al. 2016. "EVALUATION OF ULTRASONIC PHASED-ARRAY FOR DETECTION OF PLANAR FLAWS IN HIGH-DENSITY POLYETHYLENE (HDPE) BUTT-FUSION JOINTS." In ASME Pressure Vessels and Piping Conference (2016), July 17-21, 2016, Vancouver, British Columbia, Canada, 6B: Materials and Fabrication, V06BT06A051; PVP2016-63688,. New York, New York:ASME. PNNL-SA-115837. doi:10.1115/PVP2016-63688

2015

• Corley R.A., S. Kabilan, A.P. Kuprat, J.P. Carson, R.E. Jacob, K.R. Minard, and J.G. Teeguarden, et al. 2015. "COMPARATIVE RISKS OF ALDEHYDE CONSTITUENTS IN CIGARETTE SMOKE USING TRANSIENT COMPUTATIONAL FLUID DYNAMICS/PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS OF THE RAT AND HUMAN RESPIRATORY TRACTS." Toxicological Sciences 146, no. 1:65-88. PNNL-SA-106531. doi:10.1093/toxsci/kfv071
• Jacob R.E., W.J. Lamm, D.R. Einstein, M. Krueger, R.W. Glenny, and R.A. Corley. 2015. "Comparison of CT-derived Ventilation Maps with Deposition Patterns of Inhaled Microspheres in Rats." Experimental Lung Research 41, no. 3:135-145. PNNL-SA-103802. doi:10.3109/01902148.2014.984085
• Miller F.J., B. Asgharian, J.D. Schroeter, O. Price, R.A. Corley, D.R. Einstein, and R.E. Jacob, et al. 2015. "Respiratory Tract Lung Geometry and Dosimetry Model for Male Sprague-Dawley Rats." Inhalation Toxicology 26, no. 9:524-544. PNNL-SA-98526. doi:10.3109/08958378.2014.925991

2014

• Cooper W., R. Albertson, R.E. Jacob, and M.W. Westneat. 2014. "Re-description and Reassignment of the Damselfish Abudefduf luridus (Cuvier, 1830) Using Both Traditional and Geometric Morphometric Approaches." Copeia 2014, no. 3:473-480. PNNL-SA-96845. doi:10.1643/CI-13-074
• Jacob R.E., and J.P. Carson. 2014. "Automated Measurement of Heterogeneity in CT Images of Healthy and Diseased Rat Lungs using Variogram Analysis of an Octree Decomposition." BMC Medical Imaging 14. PNNL-SA-91444. doi:10.1186/1471-2342-14-1
• Miller F.J., B. Asgharian, J.D. Schroeter, O. Price, R.A. Corley, D.R. Einstein, and R.E. Jacob, et al. 2014. "Respiratory tract lung geometry and dosimetry model for male Sprague-Dawley rats." Inhalation Toxicology 26, no. 9:524-544. PNNL-SA-105401. doi:10.3109/08958378.2014.925991

2013

• Einstein D.R., A.P. Kuprat, X. Jiao, J.P. Carson, D.M. Einstein, R.A. Corley, and R.E. Jacob. 2013. "An Efficient Algorithm for Mapping Imaging Data to 3D Unstructured Grids in Computational Biomechanics." International Journal for Numerical Methods in Biomedical Engineering 29, no. 1:1-16. PNNL-SA-85247. doi:10.1002/cnm.2489
• Jacob R.E., J.P. Carson, M. Thomas, and D.R. Einstein. 2013. "Dynamic Multiscale Boundary Conditions for 4D CT Images of Healthy and Emphysematous Rat." PLoS One 8, no. 6:Article No. e65874. PNNL-SA-91208. doi:10.1371/journal.pone.0065874
• Jacob R.E., M.K. Murphy, J.A. Creim, and J.P. Carson. 2013. "Detecting Radiation-Induced Injury Using Rapid 3D Variogram Analysis of CT Images of Rat Lungs." Academic Radiology 20, no. 10:1264-1271. PNNL-SA-93209. doi:10.1016/j.acra.2013.07.001
• Jacob R.E., S.M. Colby, S. Kabilan, D.R. Einstein, and J.P. Carson. 2013. "In Situ Casting and Imaging of the Rat Airway Tree for Accurate 3D Reconstruction." Experimental Lung Research 39, no. 6:249-257. PNNL-SA-93540. doi:10.3109/01902148.2013.801535

2012

• Asgharian B., O. Price, G. McClellan, R.A. Corley, D.R. Einstein, R.E. Jacob, and J.R. Harkema, et al. 2012. "Development of a Rhesus Monkey Lung Geometry Model and Application to Particle Deposition in Comparison to Humans." Inhalation Toxicology 24, no. 13:869-899. PNNL-SA-90451. doi:10.3109/08958378.2012.725782
• Corley R.A., S. Kabilan, A.P. Kuprat, J.P. Carson, K.R. Minard, R.E. Jacob, and C. Timchalk, et al. 2012. "COMPARATIVE COMPUTATIONAL MODELING OF AIRFLOWS AND VAPOR DOSIMETY IN THE RESPIRATORY TRACTS OF RAT, MONKEY, AND HUMAN." Toxicological Sciences 128, no. 2:500-516. PNNL-SA-83274. doi:10.1093/toxsci/kfs168
• Minard K.R., A.P. Kuprat, S. Kabilan, R.E. Jacob, D.R. Einstein, J.P. Carson, and R.A. Corley. 2012. "Phase-Contrast MRI and CFD Modeling of Apparent 3He Gas Flow in Rat Pulmonary Airways." Journal of Magnetic Resonance 221. PNNL-SA-85956. doi:10.1016/j.jmr.2012.05.007
• Neradilek M.B., N. Polissar, D.R. Einstein, R.W. Glenny, K.R. Minard, J.P. Carson, and X. Jiao, et al. 2012. "BRANCH-BASED MODEL FOR THE DIAMETERS OF THE PULMONARY AIRWAYS: ACCOUNTING FOR DEPARTURES FROM SELF-CONSISTENCY AND REGISTRATION ERRORS." The Anatomical Record 295, no. 6:1027-1044. PNNL-SA-84465. doi:10.1002/ar.22476

2011

• Jacob R.E., and W.J. Lamm. 2011. "Stable Small Animal Mechanical Ventilation for Dynamic Lung Imaging to Support Computational Fluid Dynamics Models." PLoS One 6, no. 11:e27577. PNNL-SA-81079. doi:10.1371/journal.pone.0027577

2010

• Gierada D.S., J.C. Woods, R.E. Jacob, A.J. Bierhals, C.K. Choong, S.T. Bartel, and Y.V. Chang, et al. 2010. "Emphysema Quantification in Inflation-Fixed Lungs Using Low-Dose Computed Tomography and 3He Magnetic Resonance Imaging." Journal of Computer Assisted Tomography 34, no. 5:773-779. PNNL-SA-71651. doi:10.1097/RCT.0b013e3181e480f9
• Jacob R.E., B.G. Amidan, J.J. Soelberg, and K.R. Minard. 2010. "In Vivo MRI of Altered Proton Signal Intensity and T2 Relaxation in a Bleomycin Model of Pulmonary Inflammation and Fibrosis." Journal of Magnetic Resonance Imaging 31, no. 5:1091-1099. PNWD-SA-8775. doi:10.1002/jmri.22166

2009

• Gierada D.S., J.C. Woods, A.J. Bierhals, S.T. Bartel, J.H. Ritter, C.K. Choong, and N.A. Das, et al. 2009. "Effects of Diffusion Time on Short-Range Hyperpolarized 3He Diffusivity Measurements in Emphysema." Journal of Magnetic Resonance Imaging 30, no. 4:801-808. PNNL-SA-67338. doi:10.1002/jmri.21912
• Jacob R.E., J.P. Carson, K.M. Gideon, B.G. Amidan, C.L. Smith, C.L. Smith, and K.M. Lee. 2009. "Comparison of Two Quantitative Methods of Discerning Airspace Enlargement in Smoke-Exposed Mice." PLoS One 4, no. 8:E6670. PNWD-SA-8320. doi:10.1371/journal.pone.0006670

2008

• Einstein D.R., B. Neradilak, N. Pollisar, K.R. Minard, C. Wallis, M. Fanucchi, and J.P. Carson, et al. 2008. "An Automated Self-similarity Analysis of the Pulmonary Tree of the Sprague-Dawley Rat." The Anatomical Record 291, no. 12:1628-1648. PNNL-SA-58476. doi:10.1002/ar.20771
• Jacob R.E., K.R. Minard, G.J. Laicher, and C. Timchalk. 2008. "3D He-3 diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105. PNNL-SA-59615. doi:10.1152/japplphysiol.90375.2008
• Minard K.R., R.E. Jacob, G. Laicher, D.R. Einstein, A.P. Kuprat, and R.A. Corley. 2008. "MR Imaging of Apparent 3He Gas Transport in Narrow Pipes and Rodent Airways." Journal of Magnetic Resonance 194, no. 2:182-191. PNNL-SA-59586. doi:10.1016/j.jmr.2008.07.006

2007

• Jacob R.E., G. Laicher, and K.R. Minard. 2007. "3D MRI of Non-Gaussian ³He Gas Diffusion in the Rat Lung." Journal of Magnetic Resonance 188, no. 2:357-366. PNWD-SA-7836. doi:10.1016/j.jmr.2007.08.014

Selected Publications

2008

• Jacob RE, KR Minard, G Laicher, C Timchalk. 2008. "3D 3He Diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105:1291-1300.
• Minard KR, RE Jacob, G Laicher, DR Einstein, AP Kuprat, and RA Corley. 2008. "MR Imaging of Apparent 3He Gas Transport in Narrow Pipes and Rodent Airways." Journal of Magnetic Resonance 194:182-191.

2006

• Minard KR, DR Einstein, RE Jacob, S Kabilan, A Kuprat, C Timchalk, L Trease, and RA Corley. 2006. "Application of Magnetic Resonance (MR) Imaging for the Development and Validation of Computational Fluid Dynamic (CFD) Models of the Rat Respiratory System," Inhalation Toxicology 18:787-794.