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Fundamental and Computational Sciences Directorate

Staff information

David Hoyt

Biosystms Dynamics & Simula
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352

PNNL Publications


  • White RA, III, A Rivas-Ubach, MI Borkum, M Koberl, A Bilbao Pena, SM Colby, DW Hoyt, AK Bingol, YM Kim, JP Wendler, KK Hixson, and GC Jansson. 2017. "The state of rhizospheric science in the era of multi-omics: A practical guide to omics technologies." Rhizosphere 3(2):212-221.  doi:10.1016/j.rhisph.2017.05.003
  • Angle J, TA Morin, L Solden, AB Narrowe, GJ Smith, M Borton, C Rey-Sanchez, R Daly, G Mirfenderesgi, DW Hoyt, W Riley, CS Miller, G Bohrer, and KC Wrighton. 2017. "Methanogenesis in oxygenated soils is a substantial fraction of wetland methane emissions." Nature Communications 8:Article No. 1567.  doi:10.1038/s41467-017-01753-4
  • Booker AE, M Borton, R Daly, S Welch, CD Nicora, DW Hoyt, T Wilson, SO Purvine, R Wolfe, S Sharma, PJ Mouser, DR Cole, MS Lipton, KC Wrighton, and MJ Wilkins. 2017. "Sulfide Generation by Dominant Halanaerobium Microorganisms in Hydraulically Fractured Shales." mSphere 2:Article No. e00257-17.  doi:10.1128/mSphereDirect.00257-17
  • Bowers GM, HT Schaef, JS Loring, DW Hoyt, SD Burton, ED Walter, and RJ Kirkpatrick. 2017. "Role of Cations in CO2 Adsorption, Dynamics, and Hydration in Smectite Clays Under in situ Supercritical CO2 Conditions." Journal of Physical Chemistry C 121(1):577-592.  doi:10.1021/acs.jpcc.6b11542
  • Dalcin Martins P, DW Hoyt, S Bansal, C Mills, MM Tfaily, BA Tangen, RG Fincchiaro, MD Johnston, BC Mcadams, MJ Solensky, GJ Smith, YP Chin, and MJ Wilkins. 2017. "Abundant carbon substrates drive extremely high sulfate reduction rates and methane fluxes in Prairie Pothole Wetlands." Global Change Biology 23(8):3107-3120.  doi:10.1111/gcb.13633
  • Ilhan ZE, JK DiBaise, NG Isern, DW Hoyt, AK Marcus, DW Kang, M Crowell, BE Rittmann, and R Krajmalnik-Brown. 2017. "Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding." The ISME Journal 11(9):2047-2058.  doi:10.1038/ismej.2017.71
  • Ok S, DW Hoyt, A Andersen, J Sheets, S Welch, DR Cole, KT Mueller, and NM Washton. 2017. "Surface Interactions and Confinement of Methane: A High Pressure Magic Angle Spinning NMR and Computational Chemistry Study." Langmuir 33(6):1359-1367.  doi:10.1021/acs.langmuir.6b03590
  • Qi L, R Alamillo, WA Elliott, A Andersen, DW Hoyt, ED Walter, KS Han, NM Washton, RM Rioux, JA Dumesic, and SL Scott. 2017. "Operando Solid-State NMR Observation of Solvent-Mediated Adsorption-Reaction of Carbohydrates in Zeolites." ACS Catalysis 7(5):3489-3500.  doi:10.1021/acscatal.7b01045
  • Schaef HT, N Loganathan, GM Bowers, RJ Kirkpatrick, AO Yazaydin, SD Burton, DW Hoyt, S Thanthiriwatte, DA Dixon, BP McGrail, KM Rosso, ES Ilton, and JS Loring. 2017. "Tipping Point for Expansion of Layered Aluminosilicates in Weakly Polar Solvents: Supercritical CO2." ACS Applied Materials & Interfaces (9):36783-36791.  doi:10.1021/acsami.7b10590
  • Solden L, DW Hoyt, WB Collins, JE Plank, R Daly, E Hildebrand, TJ Beavers, R Wolfe, CD Nicora, SO Purvine, M Carstensen, MS Lipton, DE Spalinger, JL Firkins, BA Wolfe, and KC Wrighton. 2017. "New roles in hemicellulosic sugar fermentation for the uncultivated Bacteroidetes family BS11." The ISME Journal 11(3):691-703.  doi:10.1038/ismej.2016.150


  • Daly R, MA Borton, MJ Wilkins, DW Hoyt, DJ Kountz, R Wolfe, S Welch, DN Marcus, R Trexler, JD MacRae, JA Krzycki, DR Cole, PJ Mouser, and KC Wrighton. 2016. "Microbial metabolisms in a new 2.5 km deep ecosystem created by hydraulic fracturing in shales." Nature Microbiology 1(10):Article No. 16146.  doi:10.1038/nmicrobiol.2016.146
  • Walker LR, DW Hoyt, SM Walker, JK Ward, CD Nicora, and AK Bingol. 2016. "Unambiguous Metabolite Identification in High-throughput Metabolomics by Hybrid 1D 1H NMR/ESI MS1 Approach." Magnetic Resonance in Chemistry 54(12):998-1003.  doi:10.1002/mrc.4503


  • Jung HB, KC Carroll, S Kabilan, DJ Heldebrant, DW Hoyt, L Zhong, T Varga, SA Stephens, L Adams, A Bonneville, AP Kuprat, and CA Fernandez. 2015. "Stimuli-Responsive/Rheoreversible Hydraulic Fracturing Fluids as a Greener Alternative to Support Geothermal and Fossil Energy Production." Green Chemistry 17(5):2799-2812.  doi:10.1039/c4gc01917b


  • Wilkins MJ, DW Hoyt, MJ Marshall, PA Alderson, AE Plymale, LM Markillie, AE Tucker, ED Walter, BE Linggi, A Dohnalkova, and RC Taylor. 2014. "CO2 exposure at pressure impacts metabolism and stress responses in the model sulfate-reducing bacterium Desulfovibrio vulgaris strain Hildenborough." Frontiers in Microbiology 5:Article No. 507.  doi:10.3389/fmicb.2014.00507
  • Bowers GM, DW Hoyt, SD Burton, BO Ferguson, T Varga, and RJ Kirkpatrick. 2014. "In Situ 13C and 23Na Magic Angle Spinning NMR Investigation of Supercritical CO2 Incorporation in Smectite-Natural Organic Matter Composites." Journal of Physical Chemistry C 118(7):3564-3573.  doi:10.1021/jp410535d


  • Feng J, JZ Hu, SD Burton, and DW Hoyt. 2013. "High Resolution Magic Angle Spinning 1H-NMR Metabolic Profiling of Nanoliter Biological Tissues at High Magnetic Field ." Chinese Journal of Magnetic Resonance 30(1):1-11. 
  • Turcu RVF, DW Hoyt, KM Rosso, JA Sears, Jr, JS Loring, AR Felmy, and JZ Hu. 2013. "Rotor Design for High Pressure Magic Angle Spinning Nuclear Magnetic Resonance." Journal of Magnetic Resonance 226:64-69.  doi:10.1016/j.jmr.2012.08.009
  • Loring JS, HT Schaef, CJ Thompson, RVF Turcu, QR Miller, J Chen, JZ Hu, DW Hoyt, PF Martin, ES Ilton, AR Felmy, and KM Rosso. 2013. "Clay hydration/dehydration in dry to water-saturated supercritical CO2: Implications for caprock integrity." Energy Procedia 37:5443-54448.  doi:10.1016/j.egypro.2013.06.463
  • Miller QRS, CJ Thompson, JS Loring, CF Windisch, Jr, ME Bowden, DW Hoyt, JZ Hu, BW Arey, KM Rosso, and HT Schaef. 2013. "Insights into Silicate Carbonation Processes in Water-Bearing Supercritical CO2 Fluids." International Journal of Greenhouse Gas Control 15:104-118.  doi:10.1016/j.ijggc.2013.02.005


  • Hu JZ, JA Sears, Jr, HS Mehta, JJ Ford, JH Kwak, K Zhu, Y Wang, J Liu, DW Hoyt, and CHF Peden. 2012. "A Large Sample Volume Magic Angle Spinning Nuclear Magnetic Resonance Probe for In-Situ Investigations with Constant Flow of Reactants." Physical Chemistry Chemical Physics. PCCP 14(7):2137-2143.  doi:10.1039/c1cp22692d
  • Loring JS, HT Schaef, RVF Turcu, CJ Thompson, QRS Miller, PF Martin, JZ Hu, DW Hoyt, O Qafoku, ES Ilton, AR Felmy, and KM Rosso. 2012. "In Situ Molecular Spectroscopic Evidence for CO2 Intercalation into Montmorillonite in Supercritical Carbon Dioxide." Langmuir 28(18):7125-7128.  doi:10.1021/la301136w


  • Ahring BK, NS Baliga, JR Frederickson, S Kaplan, HB Pakrasi, JG Pounds, I shah, S Slater, G Stacey, KJ Auberry, DR Baer, DML Brown, DE Cowley, DW Hoyt, DW Koppenaal, BE Linggi, KT Mueller, G Orr, EW Robinson, RG Teller, HS Wiley, NJ Hess, L Pasa-Tolic, KM Waters, and KD Rodland. 2011. Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP)PNNL-20717, Pacific Northwest National Laboratory, Richland, WA. 
  • Brown GE, A Chaka, DK Shuh, EE Roden, CJ Werth, NJ Hess, AR Felmy, KM Rosso, DR Baer, VL Bailey, ME Bowden, JW Grate, DW Hoyt, LR Kuprat, AS Lea, KT Mueller, M Oostrom, G Orr, L Pasa-Tolic, C Plata, EW Robinson, RG Teller, S Thevuthasan, H Wang, HS Wiley, and MJ Wilkins. 2011. EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel MeetingPNNL-20601, Pacific Northwest National Laboratory, Richland, WA. 
  • Campbell CT, AK Datye, GA Henkelman, RF Lobo, WF Schneider, LD Spicer, WT Tysoe, JM Vohs, DR Baer, DW Hoyt, S Thevuthasan, KT Mueller, CM Wang, NM Washton, I Lyubinetsky, RG Teller, A Andersen, N Govind, K Kowalski, BC Kabius, H Wang, AA Campbell, WA Shelton, EJ Bylaska, CHF Peden, Y Wang, DL King, MA Henderson, RJ Rousseau, J Szanyi, Z Dohnalek, D Mei, BC Garrett, D Ray, JH Futrell, J Laskin, DL DuBois, LR Kuprat, and C Plata. 2011. EMSL and Institute for Integrated Catalysis (IIC) Catalysis WorkshopPNNL-20426, Pacific Northwest National Laboratory, Richland, WA. 
  • Hoyt DW, RVF Turcu, JA Sears, Jr, KM Rosso, SD Burton, AR Felmy, and JZ Hu. 2011. "High-pressure Magic Angle Spinning Nuclear Magnetic Resonance ." Journal of Magnetic Resonance 212(2):378-385.  doi:10.1016/j.jmr.2011.07.019
  • Hoyt DW, RVF Turcu, JA Sears, Jr, KM Rosso, SD Burton, JH Kwak, AR Felmy, and JZ Hu. 2011. "IN SITU MAGIC ANGLE SPINNING NMR FOR STUDYING GEOLOGICAL CO(2) SEQUESTRATION ." In 241st National Meeting and Exposition of the American Chemical Society, March 27-31, 2011, Anaheim, California, vol. 241, pp. 245-Fuel.  American Chemical Society, Washington DC. 
  • Kwak JH, JZ Hu, RVF Turcu, KM Rosso, ES Ilton, CM Wang, JA Sears, Jr, MH Engelhard, AR Felmy, and DW Hoyt. 2011. "The Role of H2O in the Carbonation of Forsterite in Supercritical CO2." International Journal of Greenhouse Gas Control 5(4):1081-1092.  doi:10.1016/j.ijggc.2011.05.013
  • Teklemichael ST, WMH Oo, MC Matthew, ED Walter, and DW Hoyt. 2011. "Acceptors in ZnO nanocrystals." Applied Physics Letters 98(23):Article No. 232112.  doi:10.1063/1.3598411
  • White MD, BP McGrail, HT Schaef, JZ Hu, DW Hoyt, AR Felmy, KM Rosso, and SK Wurstner. 2011. "Multiphase Sequestration Geochemistry: Model for Mineral Carbonation." Energy Procedia 4:5009-5016.  doi:10.1016/j.egypro.2011.02.472


  • Kwak JH, JZ Hu, DW Hoyt, JA Sears, Jr, CM Wang, KM Rosso, and AR Felmy. 2010. "Metal Carbonation of Forsterite in Supercritical CO2 and H2O Using Solid State 29Si, 13C NMR Spectroscop." Journal of Physical Chemistry C 114(9):4126 - 4134.  doi:10.1021/jp1001308


  • Chen B, X Ren, T Neville, WG Jerome, DW Hoyt, DL Sparks, G Ren, and J Wang. 2009. "Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes." Protein Science 18(5):921-935.  doi:10.1002/pro.101
  • Hu JZ, JA Sears, Jr, JH Kwak, DW Hoyt, Y Wang, and CHF Peden. 2009. "An Isotropic Chemical Shift-Chemical Shift Anisotropic Correlation Experiment Using Discrete Magic Angle Turning." Journal of Magnetic Resonance 198(1):105-110. 


  • Briknarova K, X Zhou, AC Satterthwait, DW Hoyt, KR Ely, and S Huang. 2008. "Structural Studies of the SET Domain from RIZ1 Tumor Suppressor." Biochemical and Biophysical Research Communications 366(3):807-813.  doi:10.1016/j.bbrc.2007.12.034


  • Ren X, Y Yang, T Neville, DW Hoyt, DL Sparks, and J Wang. 2007. "A complete backbone spectral assignment of human apolipoprotein AI on a 38 kDa preßHDL (Lp1-AI) particle ." Biomolecular NMR Assignments 1(1):69-71. 
  • Smirnov S, NG Isern, ZG Jiang, DW Hoyt, and CJ Mcknight. 2007. "The Isolated Sixth Gelsolin Repeat and Headpiece Domain of Villin Bundle F-Actin in the Presence of Calcium and Are Linked by a 40-Residue Unstructured Sequence ." Biochemistry 46(25):7488-7496.  doi:10.1021/bi700110v
  • Yang Y, DW Hoyt, and J Wang. 2007. "A Complete NMR Spectral Assignment of the Lipid-free Mouse Apolipoprotein A-I (ApoAI) C-terminal Truncation Mutant, ApoAI(1-216)." Biomolecular NMR Assignments 1(1):109-111.  doi:10.1007/s12104-007-9031-2


  • Brzovic PS, AV Lissounov, D Christensen, DW Hoyt, and RE Klevit. 2006. "A UbcH5/Ubiquitin Noncovalent Complex is Required for Processive BRCA1-Directed Ubiquitination." Molecular Cell 21(6):873-880. 


  • Briknarova K, F Nasertorabi, ML Havert, E Eggleston, DW Hoyt, C Li, AJ Olson, K Vuori, and KR Ely. 2005. "The Serine-rich Domain from Crk-associated Substrate (p130Cas) is a Four-helix Bundle." Journal of Biological Chemistry 280(23):21908-21914. 
  • Xu C, A Sivashanmugam, DW Hoyt, and J Wang. 2005. "A Complete Backbone Assignment of the Apolipoprotein E LDL Receptor Binding Domain [Letter to the Editor]." Journal of Biomolecular NMR 32(2):177.  doi:10.1007/s10858-005-6729-2


  • Hoyt DW, SD Burton, MR Peterson, JD Myers, and G Chin, Jr. 2004. "Expanding Your Laboratory by Accessing Collaboratory Resources." Analytical and Bioanalytical Chemistry 378(6):1408-1410. 


  • Briknarova K, M Akermann, DW Hoyt, E Ruoslahti, and KR Ely. 2003. "Anastellin, an FN3 Fragment with Fibronectin Polymerization Activity, Resembles Amyloid Fibril Precursors." Journal of Molecular Biology 332(1):205-215. 
  • Kreishman-Detrick M, C Egile, DW Hoyt, JJ Ford, R Li, and MK Rosen. 2003. "NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex." Biochemistry 42(28):8579-8586. 
  • Lowry DF, DW Hoyt, FA Khazi, JR Bagu, AG Lindsey, and DM Wilson Iii. 2003. "Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1 ." Journal of Molecular Biology 329(2):311-322. 
  • Lowry DF, DW Hoyt, FA Khazi, JR Bagu, AG Lindsey, and DM Wilson. 2003. "Investigation of the Role of the Histidine-Aspartate Pair in the Human Exonuclease III-like Abasic Endonuclease, Ape1 ." Journal of Molecular Biology 329(2):311-322. 


  • Briknarova K, S Takayama, S Homma, K Baker, E Cabezas, DW Hoyt, Z Li, AC Satterthwait, and KR Ely. 2002. "BAG4/SODD Protein Contains a Short BAG Domain." Journal of Biological Chemistry 277(34):31172-31178. 
  • Chin G, Jr, JD Myers, and DW Hoyt. 2002. "Social Networks in the Virtual Science Laboratory." Communications of the ACM 45(8):87-92. 


  • Briknarova K, S Takayama, L Brive, ML Havert, DA Knee, J Velasco, S Homma, E Cabezas, J Stuart, DW Hoyt, AC Satterthwait, M Llinas, JC Reed , and KR Ely. 2001. "Structural Analysis of BAG1 Cochaperone and Its Interactions With Hsc70 Heat Shock Protein." Nature Structural Biology 8(4):349-352. 
  • Bryant PL, C Harwell, AA Mrse, EF Emery, Z Gan, T Caldwell, AP Reyes, P Kuhns, DW Hoyt, LS Simeral, RW Hall, and LG Butler. 2001. "Structural Characterization of MAO and Related Aluminum Complexes. 1. Solid-State 27 Al NMR with Comparison to EFG Tensors from ab Initio Molecular Orbital Calculations." Journal of the American Chemical Society 123:12009-12017. 
  • Brzovic PS, P Rajagopal, DW Hoyt, MC King, and RE Klevit. 2001. "Structure of a BRCA1/BARD1 Complex: a Heterodimeric RING-RING Interaction." Nature Structural Biology 8(10):833-837. 


  • Liu K, HS Cho, DW Hoyt, TN Nguyen, P Olds, JW Kelly, and D Wemmer. 2000. "Deuterium-proton Exchange on the Native Wild-type Transthyretin Tetramer Identifies the Stable Core of the Individual Subunits and Indicates Mobility at the Subunit Interface." Journal of Molecular Biology 303(4):555-565. 

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