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Fundamental and Computational Sciences Directorate

Staff information

Lance Seefeldt

Joint Appointment
Pacific Northwest National Laboratory
PO Box 999
Richland, WA 99352

PNNL Publications


  • Chen J.G., R.M. Crooks, L.C. Seefeldt, K.L. Bren, R.M. Bullock, M.Y. Darensbourg, and P.L. Holland, et al. 2018. "Beyond Fossil-Fuel-Driven Nitrogen Transformations." Science 360, no. 6391. PNNL-SA-130348. doi:10.1126/science.aar6611
  • Peters J.W., D.N. Beratan, B.P. Bothner, R. Dyer, C. Harwood, Z.M. Heiden, and R. Hille, et al. 2018. "A new era for electron bifurcation." Current Opinion in Chemical Biology 47. PNNL-SA-138678. doi:10.1016/j.cbpa.2018.07.026
  • Seefeldt L.C., B. Hoffman, J.W. Peters, S. Raugei, D.N. Beratan, E. Antony, and D.R. Dean. 2018. "Energy Transduction in Nitrogenase." Accounts of Chemical Research 51, no. 9:2179-2186. PNNL-SA-138677. doi:10.1021/acs.accounts.8b00112
  • Seefeldt L.C., J.W. Peters, D.N. Beratan, B.P. Bothner, S.D. Minteer, S. Raugei, and B. Hoffman. 2018. "Control of electron transfer in nitrogenase." Current Opinion in Chemical Biology 47. PNNL-SA-138679. doi:10.1016/j.cbpa.2018.08.011


  • Khadka N., R.D. Milton, S. Shaw, D. Lukoyanov, D.R. Dean, S.D. Minteer, and S. Raugei, et al. 2017. "Mechanism of Nitrogenase H-2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects." Journal of the American Chemical Society 139, no. 38:13518-13524. PNNL-SA-128474. doi:10.1021/jacs.7b07311
  • Lukoyanov D., N. Khadka, D.R. Dean, S. Raugei, L.C. Seefeldt, and B. Hoffman. 2017. "Photoinduced Reductive Elimination of H2 from the Nitrogenase Dihydride (Janus) State Involves a FeMo-cofactor-H2 Intermediate." Inorganic Chemistry 56, no. 4:2233-2240. PNNL-SA-123286. doi:10.1021/acs.inorgchem.6b02899


  • Danyal K., S. Shaw, T.R. Page, S.S. Duval, M. Horitani, A.R. Marts, and D. Lukoyanov, et al. 2016. "Negative cooperativity in the nitrogenase Fe protein electron delivery cycle." Proceedings of the National Academy of Sciences of the United States of America 113, no. 40:E5783-E5791. PNNL-SA-111505. doi:10.1073/pnas.1613089113


  • Danyal K., A.J. Rasmussen, S.M. Keable, B.S. Inglet, S. Shaw, O. Zadvornyy, and S.S. Duval, et al. 2015. "Fe Protein-Independent Substrate Reduction by Nitrogenase MoFe Protein Variants." Biochemistry 54, no. 15:2456-2462. PNNL-SA-108124. doi:10.1021/acs.biochem.5b00140


  • Smith D.M., K. Danyal, S. Raugei, and L.C. Seefeldt. 2014. "Substrate Channel in Nitrogenase Revealed by a Molecular Dynamics Approach." Biochemistry 53, no. 14:2278-2285. PNNL-SA-98485. doi:10.1021/bi401313j

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