Staff information

Biography

Dr. Kristin Burnum-Johnson is a Senior Scientist and Team Lead of the Environmental Molecular Sciences Laboratory’s Metabolomics group at PNNL. Kristin earned her Ph.D. in Biochemistry from Vanderbilt University with Prof. Richard M. Caprioli, and then completed a postdoctoral fellowship at PNNL with Dr. Richard D. Smith. At PNNL, her research is dedicated to characterizing the molecular landscape of heterogeneous samples using novel mass spectrometry approaches to address specific biological, medical, and environmental research questions. These approaches involve multi-dimensional liquid chromatography and ion mobility separations in conjunction with mass spectrometry to measure proteins, lipids, and metabolites.

Kristin was selected to receive a 2019 Early Career Research Program award from the U.S. Department of Energy Office of Science. Her project aims to discover and track molecular interactions among microbes in complex communities. Understanding symbiotic relationships at the protein, lipid, and metabolite level will provide insight into how consortia accomplish difficult tasks, such as breaking down plant material into energy-rich sugars.

Education and Credentials

• B.S., Biochemistry (Chemistry), University of Washington, Seattle, WA, 2002
• Ph.D., Biochemistry, Vanderbilt University, Nashville, TN, 2008

PNNL Publications

2024

• Burnum-Johnson K.E. 2024. Agilent AgileBioFoundry CRADA - CRADA 398 (Abstract). PNNL-35281. Richland, WA: Pacific Northwest National Laboratory.
• Eisfeld-Fenney A.J., L.N. Anderson, S. Fan, K.B. Walters, P.J. Halfmann, D. Westhoff-Smith, and L.B. Thackray, et al. 2024. "A compendium of multi-omics data illuminating host responses to lethal human virus infections." Scientific Data 11. PNNL-SA-189528. doi:10.1038/s41597-024-03124-3
• Sarkar S., C. Dieter, J.E. Kyle, M. Guney, D. Sarbaugh, R. Yin, and X. Li, et al. 2024. "Regulation of ß-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis." Cell Communication and Signaling 22, no. _:141. PNNL-SA-152364. doi:10.1101/2020.03.23.004481

2023

• Bilbao A., N. Munoz Munoz, J. Kim, D.J. Orton, Y. Gao, K. Poorey, and K.R. Pomraning, et al. 2023. "PeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements." Nature Communications 14, no. 2023:2461. PNNL-SA-174727. doi:10.1038/s41467-023-37031-9
• Burnum-Johnson K.E., A. Apffel, A. Tsalenko, C.J. Petzold, and K. Poorey. 2023. Agilent AgileBioFoundry CRADA - CRADA 398 (Final Report). PNNL-33977. Richland, WA: Pacific Northwest National Laboratory. Agilent AgileBioFoundry CRADA - CRADA 398 (Final Report)
• Coradetti S.T., P.A. Adamczyk, D. Liu, Y. Gao, P.B. Otoupal, G.M. Geiselman, and B.M. Webb-Robertson, et al. 2023. "Engineering Transcriptional Regulation of Pentose Metabolism in Rhodosporidium toruloides for Improved Conversion of Xylose to Bioproducts." Microbial Cell Factories 22. PNNL-SA-177272. doi:10.1186/s12934-023-02148-5
• Dai Z., K.R. Pomraning, S. Deng, J. Kim, K.B. Campbell, A.L. Robles, and B.A. Hofstad, et al. 2023. "Metabolic engineering to improve production of 3-hydroxypropionic acid from corn-stover hydrolysate in Aspergillus species." Biotechnology for Biofuels and Bioproducts 16. PNNL-SA-182738. doi:10.1186/s13068-023-02288-1
• Deng S., J. Kim, K.R. Pomraning, Y. Gao, J.E. Evans, B.A. Hofstad, and Z. Dai, et al. 2023. "Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus." Metabolic Engineering 80. PNNL-SA-181297. doi:10.1016/j.ymben.2023.09.011
• Gosline S., M. Velickovic, J.C. Pino, L.Z. Day, I.K. Attah, A.C. Swensen, and V.G. Danna, et al. 2023. "Proteome mapping of the human pancreatic islet microenvironment reveals endocrine-exocrine signaling sphere of influence." Molecular & Cellular Proteomics 22, no. 8:Art. No. 100592. PNNL-SA-179489. doi:10.1016/j.mcpro.2023.100592
• Liu D., H. Hwang, P.B. Otoupal, G.M. Geiselman, J. Kim, K.R. Pomraning, and Y. Kim, et al. 2023. "Engineering Rhodosporidium toruloides for Production of 3-Hydroxypropionic Acid from Lignocellulosic Hydrolysate." Metabolic Engineering 78. PNNL-SA-185285. doi:10.1016/j.ymben.2023.05.001
• McNaught K.J., E. Kuatsjah, M. Zahn, E. Teixeira Prates, H. Shao, G. Bentley, and A. Pickford, et al. 2023. "Initiation of fatty acid biosynthesis in Pseudomonas putida KT2440." Metabolic Engineering 76. PNNL-SA-179252. doi:10.1016/j.ymben.2023.02.006
• Nakayasu E.S., M.A. Gritsenko, Y. Kim, J.E. Kyle, K.G. Stratton, C.D. Nicora, and N. Munoz Munoz, et al. 2023. "Elucidating regulatory processes of intense physical activity by multi-omics analysis." Military Medical Research 10, no. 1:48. PNNL-SA-158793. doi:10.1186/s40779-023-00477-5

2022

• Burnum-Johnson K.E., T.P. Conrads, R. Drake, A.E. Herr, R. Iyengar, R.T. Kelly, and E. Lundberg, et al. 2022. "New views of old proteins: clarifying the enigmatic proteome." Molecular & Cellular Proteomics 21, no. 7:Art. No. 100254. PNNL-SA-163440. doi:10.1016/j.mcpro.2022.100254
• Kwon Y., P.D. Piehowski, R. Zhao, R.L. Sontag, R.J. Moore, K.E. Burnum-Johnson, and R.D. Smith, et al. 2022. "Hanging drop sample preparation improves sensitivity of spatial proteomics." Lab on a Chip 22, no. 15:2869-2877. PNNL-SA-172863. doi:10.1039/D2LC00384H
• Lee J., H.D. Mitchell, M.C. Burnet, R. Wu, S.C. Jenson, E.D. Merkley, and E.S. Nakayasu, et al. 2022. "Uncovering Hidden Members and Functions of the Soil Microbiome Using De Novo Metaproteomics." Journal of Proteome Research 21, no. 8:2023-2035. PNNL-SA-138497. doi:10.1021/acs.jproteome.2c00334
• Ling C., G. Peabody, D. Salvachua, Y. Kim, C.M. Kneucker, C.H. Calvey, and M.A. Monninger, et al. 2022. "Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering." Nature Communications 13. PNNL-SA-168423. doi:10.1038/s41467-022-32296-y
• Pomraning K.R., Z. Dai, N. Munoz Munoz, Y. Kim, Y. Gao, S. Deng, and T.L. Lemmon, et al. 2022. "Itaconic acid production is regulated by laeA in Aspergillus pseudoterreus." Metabolic Engineering Communications 15. PNNL-SA-171876. doi:10.1016/j.mec.2022.e00203

2021

• Khadempour L., J.E. Kyle, B.M. Webb-Robertson, C.D. Nicora, F.B. Smith, R.D. Smith, and M.S. Lipton, et al. 2021. "From plants to ants: Fungal modification of leaf lipids for nutrition and communication in the leaf-cutter ant fungal garden ecosystem." mSystems 6, no. 2:e01307-20. PNNL-SA-147384. doi:10.1128/mSystems.01307-20
• Kim J., S.T. Coradetti, Y. Kim, Y. Gao, J. Yaegashi, J.D. Zucker, and N. Munoz Munoz, et al. 2021. "Multi-omics driven metabolic network reconstruction and analysis of lignocellulosic carbon utilization in Rhodosporidium toruloides." Frontiers in Bioengineering and Biotechnology 8. PNNL-SA-156767. doi:10.3389/fbioe.2020.612832
• Kirby J., G.M. Geiselman, J. Yaegashi, J. Kim, X. Zhuang, M. Tran-Gyamfi, and J. Prahl, et al. 2021. "Further engineering of R. toruloides for the production of terpenes from lignocellulosic biomass." Biotechnology for Biofuels 14, no. 1:Article No. 101. PNNL-SA-162406. doi:10.1186/s13068-021-01950-w
• Pomraning K.R., Z. Dai, N. Munoz Munoz, Y. Kim, Y. Gao, S. Deng, and J. Kim, et al. 2021. "Integration of proteomics and metabolomics into the Design, Build, Test, Learn cycle to improve 3-hydroxypropionic acid production in Aspergillus pseudoterreus." Frontiers in Bioengineering and Biotechnology 9. PNNL-SA-149911. doi:10.3389/fbioe.2021.603832
• Sims A.C., H.D. Mitchell, L. Gralinski, J.E. Kyle, K.E. Burnum-Johnson, M. Lam, and L.M. Fulcher, et al. 2021. "Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury." mBio 12, no. 4:e01572-21. PNNL-SA-162254. doi:10.1128/mBio.01572-21
• Tsai C., P. Zhang, D. Scholten, K.D. Martin, Y. Wang, R. Zhao, and W.B. Chrisler, et al. 2021. "Surfactant-assisted one-pot sample preparation for label-free single-cell proteomics." Communications Biology 4, no. 1:265. PNNL-SA-150656. doi:10.1038/s42003-021-01797-9
• Velickovic D., R.K. Chu, C. Henkel, A. Nyhuis, N. Tao, J.E. Kyle, and J.N. Adkins, et al. 2021. "Preserved and variable spatial-chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade." Plant-Environment Interactions 2, no. 1:28-35. PNNL-SA-158820. doi:10.1002/pei3.10038
• Wu R., M.R. Davison, Y. Gao, C.D. Nicora, J.E. McDermott, K.E. Burnum-Johnson, and K.S. Hofmockel, et al. 2021. "Moisture Modulates Soil Reservoirs of Active DNA and RNA Viruses." Communications Biology 4, no. 1:992. PNNL-SA-160635. doi:10.1038/s42003-021-02514-2

2020

• Chaves J.E., R. Wilton, Y. Gao, N. Munoz Munoz, M.C. Burnet, Z. Schmitz, and J. Rowan, et al. 2020. "Evaluation of chromosomal insertion loci in the Pseudomonas putida KT2440 genome for predictable biosystems design." Metabolic Engineering Communications 11. PNNL-SA-155823. doi:10.1016/j.mec.2020.e00139
• Geiselman G.M., X. Zhuang, J. Kirby, M. Tran-Gyamfi, J. Prahl, E.R. Sundstrom, and Y. Gao, et al. 2020. "Production of ent-kaurene from lignocellulosic hydrolysate in Rhodosporidium toruloides." Microbial Cell Factories 19, no. 1:Article No. 24. PNNL-SA-150034. doi:10.1186/s12934-020-1293-8
• Odenkirk M.T., K.G. Stratton, L.M. Bramer, B.M. Webb-Robertson, K.J. Bloodsworth, M.E. Monroe, and K.E. Burnum-Johnson, et al. 2020. "From prevention to disease perturbations: A multi-omic assessment of exercise and myocardial infarctions." Biomolecules 11, no. 1:Article No. 40. PNNL-SA-158202. doi:10.3390/biom11010040
• Odenkirk M.T., K.G. Stratton, M.A. Gritsenko, L.M. Bramer, B.M. Webb-Robertson, K.J. Bloodsworth, and K.K. Weitz, et al. 2020. "Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools." Molecular Omics 16, no. 6:521-532. PNNL-SA-152804. doi:10.1039/d0mo00074d
• Piehowski P.D., Y. Zhu, L.M. Bramer, K.G. Stratton, R. Zhao, D.J. Orton, and R.J. Moore, et al. 2020. "Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-µm spatial resolution." Nature Communications 11, no. 1:Article No. 8. PNNL-SA-138884. doi:10.1038/s41467-019-13858-z

2019

• Burnum-Johnson K.E., X. Zheng, J.N. Dodds, J. Ash, D. Fourches, C.D. Nicora, and J.P. Wendler, et al. 2019. "Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples." Trends in Analytical Chemistry. TrAC 116. PNNL-SA-140985. doi:10.1016/j.trac.2019.04.022
• Horta M.A., N. Thieme, Y. Gao, K.E. Burnum-Johnson, C.D. Nicora, M.A. Gritsenko, and M.S. Lipton, et al. 2019. "Broad substrate-specific phosphorylation events are associated with the initial stage of plant cell wall recognition in Neurospora crassa." Frontiers in Microbiology 10. PNNL-SA-143199. doi:10.3389/fmicb.2019.02317
• Kyle J.E., K.E. Burnum-Johnson, J.P. Wendler, A.J. Eisfeld, P.J. Halfmann, T. Watanabe, and F. Sahr, et al. 2019. "Plasma lipidome reveals critical illness and recovery from human Ebola virus disease." Proceedings of the National Academy of Sciences (PNAS) 116, no. 9:3919-3928. PNNL-SA-136689. doi:10.1073/pnas.1815356116
• Merkley E.D., K.E. Burnum-Johnson, L.N. Anderson, S.C. Jenson, and K.L. Wahl. 2019. "Uniformly 15N-Labeled Recombinant Ricin A-chain as an Internal Retention Time Standard for Increased Confidence in Forensic Identification of Ricin by Untargeted Nanoflow Liquid Chromatography-Tandem Mass Spectrometry." Analytical Chemistry 91, no. 21:13372-13376. PNNL-SA-145704. doi:10.1021/acs.analchem.9b03389
• Nicora C.D., M.A. Gritsenko, A.K. Lipton, K.L. Wahl, and K.E. Burnum-Johnson. 2019. "Proteomic Sample Preparation Techniques: Towards Forensic Proteomic Applications." In Applications in Forensic Proteomics: Protein Identification and Profiling. ACS Symposium Series, edited by E.D. Merkley. 29-46. Washington D.C.:American Chemical Society. PNNL-SA-143184. doi:10.1021/bk-2019-1339.ch003
• Singer R.A., L. Arnes, Y. Cui, J. Wang, Y. Gao, M. Guney, and K.E. Burnum-Johnson, et al. 2019. "The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function." Cell Metabolism 30, no. 6:1091-1106.e8. PNNL-SA-146887. doi:10.1016/j.cmet.2019.09.013
• Snyder M., S. Lin, A. Posgai, M.A. Atkinson, A. Regev, J. Rood, and O. Rozenblatt-Rosen, et al. 2019. "The human body at cellular resolution: the NIH Human Biomolecular Atlas Program." Nature 574, no. 7777:187-192. PNNL-SA-146510. doi:10.1038/s41586-019-1629-x
• Stratton K.G., B.M. Webb-Robertson, L. McCue, B.A. Stanfill, D.M. Claborne, I.G. Godinez, and T. Johansen, et al. 2019. "pmartR: Quality Control and Statistics for Mass Spectrometry-Based Biological Data." Journal of Proteome Research 18, no. 3:1418-1425. PNNL-SA-123105. doi:10.1021/acs.jproteome.8b00760
• Yin R., K.E. Burnum-Johnson, X. Sun, S.K. Dey, and J. Laskin. 2019. "High Spatial Resolution Imaging of Biological Tissues Using Nanospray Desorption Electrospray Ionization Mass Spectrometry." Nature Protocols 14, no. 12:3445-3470. PNNL-SA-142602. doi:10.1038/s41596-019-0237-4

2018

• Duncan K.D., R. Fang, J. Yuan, R.K. Chu, S.K. Dey, K.E. Burnum-Johnson, and I. Lanekoff. 2018. "Quantitative mass spectrometry imaging of prostaglandins as silver ion adducts with nanospray desorption electrospray ionization." Analytical Chemistry 90, no. 12:7246-7252. PNNL-SA-131518. doi:10.1021/acs.analchem.8b00350
• Kedia K., J.P. Wendler, E.M. Baker, K.E. Burnum-Johnson, L.G. Jarsberg, K.G. Stratton, and A.T. Wright, et al. 2018. "Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis." Tuberculosis 112. PNNL-SA-137966. doi:10.1016/j.tube.2018.07.005
• Kyle J.E., N.A. Aly, X. Zheng, K.E. Burnum-Johnson, R.D. Smith, and E.M. Baker. 2018. "Evaluating lipid mediator structural complexity using ion mobility spectrometry combined with mass spectrometry." Bioanalysis 10, no. 5:279-289. PNNL-SA-130733. doi:10.4155/bio-2017-0245
• Menachery V.D., A. Schafer, K.E. Burnum-Johnson, H.D. Mitchell, A.J. Eisfeld-Fenney, K.B. Walters, and C.D. Nicora, et al. 2018. "MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape." Proceedings of the National Academy of Sciences (PNAS) 115, no. 5:E1012-E1021. PNNL-SA-126254. doi:10.1073/pnas.1706928115
• Mercer N., T.K. Sigdel, S. Nandoe, C.D. Nicora, K.E. Burnum-Johnson, W. Qian, and M. Sarwal. 2018. "Urinary Virome perturbations in kidney transplantation." Frontiers in Medicine 5. PNNL-SA-130392. doi:10.3389/fmed.2018.00072
• Nicora C.D., K.E. Burnum-Johnson, E.S. Nakayasu, C.P. Casey, R.A. White, T. Roy Chowdhury, and J.E. Kyle, et al. 2018. "The MPLEx Protocol for Multi-Omic Analyses of Soil Samples." Journal of Visualized Experiments e57343, no. 135. PNNL-SA-129344. doi:10.3791/57343
• Yin R., J.E. Kyle, K.E. Burnum-Johnson, K.J. Bloodsworth, L. Sussel, C.K. Ansong, and J. Laskin. 2018. "High Spatial Resolution Imaging of Mouse Pancreatic Islets Using Nanospray Desorption Electrospray Ionization Mass Spectrometry." Analytical Chemistry 90, no. 11:6548-6555. PNNL-SA-162133. doi:10.1021/acs.analchem.8b00161

2017

• Burnum-Johnson K.E., E.M. Baker, and T.O. Metz. 2017. "Characterizing the Lipid and Metabolite Changes Associated with Placental Function and Pregnancy Complications Using Ion Mobility Spectrometry-Mass Spectrometry and Mass Spectrometry Imaging." Placenta 60, no. Supplement 1:S67-S72. PNNL-SA-123563. doi:10.1016/j.placenta.2017.03.016
• Burnum-Johnson K.E., J.E. Kyle, A.J. Eisfeld, C.P. Casey, K.G. Stratton, J.F. Gonzalez, and F. Habyarimana, et al. 2017. "MPLEx: A method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling." Analyst 142, no. 3:442-448. PNNL-SA-116063. doi:10.1039/c6an02486f
• Eisfeld A.J., P. Halfmann, J.P. Wendler, J.E. Kyle, K.E. Burnum-Johnson, Z. Peralta, and T. Maemura, et al. 2017. "Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis." Cell Host & Microbe 22, no. 6:817-829. PNNL-SA-120881. doi:10.1016/j.chom.2017.10.011
• Kyle J.E., C.P. Casey, K.G. Stratton, E.M. Zink, Y. Kim, X. Zheng, and M.E. Monroe, et al. 2017. "Comparing Identified and Statistically Significant Lipids and Metabolites in 15-Year Old Serum and Dried Blood Spot Samples for Longitudinal Studies." Rapid Communications in Mass Spectrometry 31, no. 5:447-456. PNNL-SA-121197. doi:10.1002/rcm.7808
• Zheng X., R. Wojcik, X. Zhang, Y.M. Ibrahim, K.E. Burnum-Johnson, D.J. Orton, and M.E. Monroe, et al. 2017. "Coupling Front-end Separations, Ion Mobility Spectrometry, and Mass Spectrometry for Enhanced Multidimensional Biological and Environmental Analyses." Annual Review of Analytical Chemistry 10. PNNL-SA-121198. doi:10.1146/annurev-anchem-061516-045212

2016

• Burnum-Johnson K.E., S. Nie, C.P. Casey, M.E. Monroe, D.J. Orton, Y.M. Ibrahim, and M.A. Gritsenko, et al. 2016. "Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry." Molecular & Cellular Proteomics 15, no. 12:3694-3705. PNNL-SA-118308. doi:10.1074/mcp.M116.061143
• Huang E.L., P.D. Piehowski, D.J. Orton, R.J. Moore, W. Qian, C.P. Casey, and X. Sun, et al. 2016. "SNaPP: Simplified Nano-Proteomics Platform for reproducible global proteomic analysis of nanogram protein quantities." Endocrinology 157, no. 3:1307-14. PNNL-SA-111854. doi:10.1210/en.2015-1821
• Khadempour L., K.E. Burnum-Johnson, E.S. Baker, C.D. Nicora, B.M. Webb-Robertson, R.A. White, and M.E. Monroe, et al. 2016. "The fungal cultivar of leaf-cutter ants produces specific enzymes in response to different plant substrates." Molecular Ecology 25, no. 22:5795-5805. PNNL-SA-113016. doi:10.1111/mec.13872
• Kyle J.E., X. Zhang, K.K. Weitz, M.E. Monroe, Y.M. Ibrahim, R.J. Moore, and J. Cha, et al. 2016. "Uncovering Biologically Significant Lipid Isomers with Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry." Analyst 141, no. 5:1649-1659. PNNL-SA-111991. doi:10.1039/C5AN02062J
• Lanekoff I., J. Cha, J.E. Kyle, S.K. Dey, J. Laskin, and K.E. Burnum-Johnson. 2016. "Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site." Scientific Reports 6. PNNL-SA-116850. doi:10.1038/srep33023
• Nakayasu E.S., C.D. Nicora, A.C. Sims, K.E. Burnum-Johnson, Y. Kim, J.E. Kyle, and M.M. Matzke, et al. 2016. "MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses." mSystems 1, no. 3:e00043-16. PNNL-SA-114737. doi:10.1128/mSystems.00043-16
• Zhang X., M.V. Romm, X. Zheng, E.M. Zink, Y. Kim, K.E. Burnum-Johnson, and D.J. Orton, et al. 2016. "SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in bio?uids." Clinical Mass Spectrometry 2. PNNL-SA-117436. doi:10.1016/j.clinms.2016.11.002

2015

• Aylward F.O., L. Khadempour, D. Tremmel, B.R. McDonald, C.D. Nicora, S. Wu, and R.J. Moore, et al. 2015. "Enrichment and Broad Representation of Plant Biomass-Degrading Enzymes in the Specialized Hyphal Swellings of Leucoagaricus gongylophorus, the Fungal Symbiont of Leaf-Cutter Ants." PLoS One 10, no. 8:e0134752. PNNL-SA-108498. doi:10.1371/journal.pone.0134752
• Baker E.S., K.E. Burnum-Johnson, Y.M. Ibrahim, D.J. Orton, M.E. Monroe, R.T. Kelly, and R.J. Moore, et al. 2015. "Enhancing Bottom-up and Top-down Proteomic Measurements with Ion Mobility Separations." Proteomics 15, no. 16:2766-2776. PNNL-SA-107785. doi:10.1002/pmic.201500048
• Cha J., K.E. Burnum-Johnson, A. Bartos, Y. Li, E.S. Baker, S.C. Tilton, and B.M. Webb-Robertson, et al. 2015. "Muscle segment homeobox genes direct embryonic diapause by limiting inflammation in the uterus." Journal of Biological Chemistry 290, no. 24:15337-15349. PNNL-SA-107786. doi:10.1074/jbc.M115.655001
• Lanekoff I.T., K.E. Burnum-Johnson, M. Thomas, J. Cha, S.K. Dey, P. yang, and M. Prieto, et al. 2015. "Three-Dimensional Imaging of Lipids and Metabolites in Tissues by Nanospray Desorption Electrospray Ionization Mass Spectrometry." Analytical and Bioanalytical Chemistry 407, no. 8:2063-2071. PNNL-SA-100218. doi:10.1007/s00216-014-8174-0

2014

• Baker E.S., K.E. Burnum-Johnson, J.M. Jacobs, D.L. Diamond, R.N. Brown, Y.M. Ibrahim, and D.J. Orton, et al. 2014. "Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry." Molecular and Cellular Proteomics 13, no. 4:1119-1127. PNNL-SA-90826. doi:10.1074/mcp.M113.034595
• Huang E.L., F.O. Aylward, Y. Kim, B.M. Webb-Robertson, C.D. Nicora, Z. Hu, and T.O. Metz, et al. 2014. "The fungus gardens of leaf-cutter ants undergo a distinct physiological transition during biomass degradation." Environmental Microbiology Reports 6, no. 4:389-95. PNNL-SA-96938. doi:10.1111/1758-2229.12163
• Martin J.L., P.A. Yates, R. Soysa, J.F. Alfaro, F. Yang, K.E. Burnum-Johnson, and V.A. Petyuk, et al. 2014. "Metabolic Reprogramming During Purine Stress in the Protozoan Pathogen Leishmania donovani." PLoS Pathogens 10, no. 2:e1003938. PNNL-SA-96975. doi:10.1371/journal.ppat.1003938

2013

• Aylward F.O., K.E. Burnum-Johnson, S.G. Tringe, C. Teiling, D. Tremmel, J. Moeller, and J.J. Scott, et al. 2013. "Leucoagaricus gongylophorus Produces Diverse Enzymes for the Degradation of Recalcitrant Plant Polymers in Leaf-Cutter Ant Fungus Gardens." Applied and Environmental Microbiology 79, no. 12:3770-3778. PNNL-SA-92750. doi:10.1128/AEM.03833-12
• Duijvesz D., K.E. Burnum-Johnson, M.A. Gritsenko, M. Hoogland, M.S. Vredenbregt-van den Berg, R. Willemsen, and T.n. Luider, et al. 2013. "Proteomic Profiling of Exosomes Leads to the Identification of Novel Biomarkers for Prostate Cancer." PLoS One 8, no. 12:Article No. e82589. PNNL-SA-88219. doi:10.1371/journal.pone.0082589
• Isanapong J., S. Hambright, A.G. Willis, A. Boonmee, S.J. Callister, K.E. Burnum-Johnson, and L. Pasa-Tolic, et al. 2013. "Development of an ecophysiological model for Diplosphaera colotermitum TAV2, a termite hindgut Verrucomicrobium." The ISME Journal 7, no. 9:1803-1813. PNNL-SA-98615. doi:10.1038/ismej.2013.74
• Lanekoff I.T., K.E. Burnum-Johnson, M. Thomas, J. Short, J.P. Carson, J. Cha, and S.K. Dey, et al. 2013. "High-Speed Tandem Mass Spectrometric in Situ Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry." Analytical Chemistry 85, no. 20:9596-9603. PNNL-SA-96267. doi:10.1021/ac401760s
• Piehowski P.D., V.A. Petyuk, J.D. Sandoval, K.E. Burnum, G.R. Kiebel, M.E. Monroe, and G.A. Anderson, et al. 2013. "STEPS: A Grid Search Methodology for Optimized Peptide Identification Filtering of MS/MS Database Search Results." Proteomics 13, no. 5:766-770. PNNL-SA-86051. doi:10.1002/pmic.201200096

2012

• Aylward F.O., K.E. Burnum, J.J. Scott, G. Suen, S.G. Tringe, S.M. Adams, and K.W. Barry, et al. 2012. "Metagenomic and metaproteomic insights into bacterial communities in leaf-cutter ant fungus gardens." The ISME Journal 6, no. 9:1688-1701. PNNL-SA-82393. doi:10.1038/ismej.2012.10
• Baker E.S., T. Liu, V.A. Petyuk, K.E. Burnum-Johnson, Y.M. Ibrahim, G.A. Anderson, and R.D. Smith. 2012. "Mass Spectrometry for Translational Proteomics: Progress and Clinical Implications." Genome Medicine 4. PNNL-SA-86783. doi:10.1186/gm364
• Burnum K.E., Y. Hirota, E.S. Baker, M. Yoshie, Y.M. Ibrahim, M.E. Monroe, and G.A. Anderson, et al. 2012. "Uterine deletion of Trp53 compromises antioxidant responses in mouse decidua." Endocrinology 153, no. 9:4568-4579. PNNL-SA-87211. doi:10.1210/en.2012-1335
• Diamond D.L., A. Krasnoselski, K.E. Burnum, M.E. Monroe, B.M. Webb-Robertson, J.E. McDermott, and M.M. Yeh, et al. 2012. "Proteome and Computational Analyses Reveal New Insights into the Mechanisms of Hepatitis C Virus Mediated Liver Disease Posttransplantation." Hepatology 56, no. 1:28-38. PNWD-SA-9552. doi:10.1002/hep.25649
• Wiedner S.D., K.E. Burnum, L.M. Pederson, L.N. Anderson, S. Fortuin, L.M. Chauvigne-Hines, and A.K. Shukla, et al. 2012. "Multiplexed Activity-based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes upon Exposure to Human Serum." Journal of Biological Chemistry 287, no. 40:33447-33459. PNNL-SA-87258. doi:10.1074/jbc.M112.394106

2011

• Burnum K.E., S.J. Callister, C.D. Nicora, S.O. Purvine, P. Hugenholtz, F. Warnecke, and R.H. Scheffrahn, et al. 2011. "Proteome Insights into the Symbiotic Relationship Between a Captive Colony of Nasutitermes corniger and its Hindgut Microbiome." The ISME Journal 5, no. 1:161-164. PNNL-SA-68831. doi:10.1038/ismej.2010.97
• Lennen R.M., M.A. Kruziki, K. Kumar, R.A. Zinkel, K.E. Burnum, M.S. Lipton, and S.W. Hoover, et al. 2011. "Membrane Stresses Induced by Overproduction of Free Fatty Acids in Escherichia coli." Applied and Environmental Microbiology 77, no. 22:8114-8128. PNNL-SA-83349. doi:10.1128/AEM.05421-11
• Zhang H., K.E. Burnum, M.L. Luna, B.O. Petritis, J. Kim, W. Qian, and R.J. Moore, et al. 2011. "Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size." Proteomics 11, no. 23:4569-4577. PNNL-SA-74159. doi:10.1002/pmic.201100037