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Fundamental and Computational Sciences Directorate

Staff information

Jordan Smith

Chem Bio & Exposure Sci Team
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352

PNNL Publications


  • Ouyang H, Q Lu, W Wang, Y Song, X Tu, C Zhu, JN Smith, D Du, Z Fu, and Y Lin. 2018. "Dual-readout Immunochromatographic Assay by Utilizing MnO2 Nanoflowers as the Unique Colorimetric/Chemiluminescent Probe." Analytical Chemistry 90(8):5747-5152.  doi:10.1021/acs.analchem.7b05247
  • Thomas DG, JN Smith, BD Thrall, DR Baer, HD Jolley, P Munusamy, VK Kodali, P Demokritou, J Cohen, and JG Teeguarden. 2018. "ISD3: A Particokinetic Model for Predicting the Combined Effects of Particle Sedimentation, Diffusion and Dissolution on Cellular Dosimetry for In Vitro Systems." Particle and Fibre Toxicology 15:Article No. 6.  doi:10.1186/s12989-018-0243-7


  • Poet TS, C Timchalk, MJ Bartels, JN Smith, R Mcdougal, D Juberg, and PS Price. 2017. "Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos." Regulatory Toxicology and Pharmacology 86:59-73.  doi:10.1016/j.yrtph.2017.02.014
  • Smith JN, D Mehinagic, S Nag, SR Crowell, and RA Corley. 2017. "In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes." Toxicology Letters 269:23-32.  doi:10.1016/j.toxlet.2017.01.008
  • Smith JN, ZA Carver, TJ Weber, and C Timchalk. 2017. "Predicting Transport of 3,5,6-Trichloro-2-pyridinol into Saliva Using a Combination Experimental and Computational Approach." Toxicological Sciences 157(2):438-450.  doi:10.1093/toxsci/kfx055
  • Smith JN, KJ Tyrrell, JR Hansen, DG Thomas, TA Murphree, AK Shukla, T Luders, JM Madden, Y Li, AT Wright, and PD Piehowski. 2017. "Plasma Protein Turnover Rates in Rats Using Stable Isotope Labeling, Global Proteomics, and Activity-Based Protein Profiling." Analytical Chemistry 89(24):13559-13566.  doi:10.1021/acs.analchem.7b03984
  • Stoddard EG, BJ Killinger, RN Nair, NC Sadler, RF Volk, SO Purvine, AK Shukla, JN Smith, and AT Wright. 2017. "Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S- Transferases." Journal of the American Chemical Society 139(45):16032-16035.  doi:10.1021/jacs.7b07378
  • Timchalk C, TJ Weber, and JN Smith. 2017. "The Need for Non- or Minimally-Invasive Biomonitoring Strategies and the Development of Pharmacokinetic/Pharmacodynamic Models for Quantification." Current Opinion in Toxicology 4:28-34.  doi:10.1016/j.cotox.2017.03.003
  • Wang Y, MM Zeinhom, M Yang, R Sun, S Wang, JN Smith, C Timchalk, L Li, Y Lin, and D Du. 2017. "A 3D-Printed, Portable, Optical-Sensing Platform for Smartphones Capable of detecting the Herbicide 2,4-Dichlorophenoxyacetic Acid." Analytical Chemistry 89(17):9339-9346.  doi:10.1021/acs.analchem.7b02139


  • Engelhard MH, JN Smith, and DR Baer. 2016. "Gold/silver Core-shell 20 nm Nanoparticles Extracted from Citrate Solution Examined by XPS." Surface Science Spectra 23(1):Article No. 29.  doi:10.1116/1.4953792
  • Sadler NC, P Nandhikonda, BJM Webb-Robertson, C Ansong, LN Anderson, JN Smith, RA Corley, and AT Wright. 2016. "Hepatic cytochrome P450 activity, abundance, and expression throughout human development." Drug Metabolism and Disposition 44(7):984-91.  doi:10.1124/dmd.115.068593
  • Zhang X, MV Romm, X Zheng, EM Zink, YM Kim, KE Burnum-Johnson, DJ Orton, A Apffel, YM Ibrahim, ME Monroe, RJ Moore, JN Smith, J Ma, RS Renslow, DG Thomas, A Blackwell, G Swinford, J Sausen, RT Kurulugama Lekamlage, N Eno, E Darland, G Stafford, JC Fjeldsted, TO Metz, JG Teeguarden, RD Smith, and ES Baker. 2016. "SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in bio?uids." Clinical Mass Spectrometry 2:1-10.  doi:10.1016/j.clinms.2016.11.002


  • Mihai C, WB Chrisler, Y Xie, D Hu, CJ Szymanski, A Tolic, J Klein, JN Smith, BJ Tarasevich, and G Orr. 2015. "Intracellular accumulation dynamics and fate of zinc ions in alveolar epithelial cells exposed to airborne ZnO nanoparticles at the air-liquid interface." Nanotoxicology 9(1):9-22.  doi:10.3109/17435390.2013.859319
  • Munusamy P, CM Wang, MH Engelhard, DR Baer, JN Smith, C Liu, VK Kodali, BD Thrall, S Chen, PE Alexandra, and MP Ryan. 2015. "Comparison of 20 nm silver nanoparticles synthesized with and without a gold core: Structure, dissolution in cell culture media, and biological impact on macrophages." Biointerphases 10(3):031003-1 to 031003-16.  doi:10.1116/1.4926547
  • Timchalk C, TJ Weber, and JN Smith. 2015. "Computational Strategy for Quantifying Human Pesticide Exposure based upon a Saliva Measurement." Frontiers in Pharmacology 6:Article No. 115.  doi:10.3389/fphar.2015.00115


  • Smith JN, PM Hinderliter, C Timchalk, MJ Bartels, and TS Poet. 2014. "A Human Life-Stage Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Chlorpyrifos: Development and Validation." Regulatory Toxicology and Pharmacology 69(3):580-597.  doi:10.1016/j.yrtph.2013.10.005


  • Smith JN. 2013. "Challenges for In vitro to in Vivo Extrapolation of Nanomaterial Dosimetry for Human Risk Assessment." Gradient EH&S Nano News 8(3):4. 
  • Teeguarden JG, C Housand, JN Smith, PM Hinderliter, R Gunawan, and C Timchalk. 2013. "A Multi-Route Model of Nicotine-Cotinine Pharmacokinetics, Pharmacodynamics and Brain Nicotinic Acetylcholine Receptor Binding in Humans." Regulatory Toxicology and Pharmacology 65(1):12-28.  doi:10.1016/J.YRTPH.2012.10.007
  • Lanekoff IT, M Thomas, JP Carson, JN Smith, C Timchalk, and J Laskin. 2013. "Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry." Analytical Chemistry 85(2):882-889.  doi:10.1021/ac302308p
  • Zhang W, Y Tang, D Du, JN Smith, C Timchalk, D Liu, and Y Lin. 2013. "Direct analysis of trichloropyridinol in human saliva using an Au nanoparticles-based immunochromatographic test strip for biomonitoring of exposure to chlorpyrifos." Talanta 114:261-267.  doi:10.1016/j.talanta.2013.06.012


  • Smith JN, J Wang, Y Lin, EM Klohe, and C Timchalk. 2012. "Pharmacokinetics and Pharmacodynamics of Chlorpyrifos and 3,5,6-Trichloro-2-pyridinol in Rat Saliva After Chlorpyrifos Administration." Toxicological Sciences 130(2):245-256.  doi:10.1093/toxsci/kfs251
  • Timchalk C, JN Smith, AL Hjerpe, TS Poet, and SK Lee. 2012. "Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat." Chapter 13 in Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. ACS Symposium Series, vol. 1099, ed. JB Knaak, C Timchalk and R Tornero-Velez, pp. 195-213.  American Chemical Society, Washington DC. 


  • Smith JN, C Timchalk, MJ Bartels, and TS Poet. 2011. "In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma." Drug Metabolism and Disposition 39(8):1353-1362.  doi:10.1124/dmd.111.038745
  • Du D, J Wang, L Wang, D Lu, JN Smith, C Timchalk, and Y Lin. 2011. "Magnetic Electrochemical Sensing Platform for Biomonitoring of Exposure to Organophosphorus Pesticides and Nerve Agents Based on Simultaneous Measurement of Total Enzyme Amount and Enzyme Activity ." Analytical Chemistry 83(10):3770-3777.  doi:10.1021/ac200217d
  • Ellison CA, JN Smith, PJ Lein, and JR Olson. 2011. "Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos." Toxicology 287(1-3):137-144.  doi:10.1016/j.tox.2011.06.010
  • Lee SK, TS Poet, JN Smith, AL Hjerpe, R Gunawan, and C Timchalk. 2011. "IMPACT OF REPEATED NICOTINE AND ALCOHOL COEXPOSURE ON IN VITRO AND IN VIVO CHLORPYRIFOS DOSIMETRY AND CHOLINESTERASE INHIBITION." Journal of Toxicology and Environmental Health Part A 74(20):1334-50. 
  • Wang L, D Du, D Lu, CT Lin, JN Smith, C Timchalk, F Liu, J Wang, and Y Lin. 2011. "Enzyme-linked immunosorbent assay for detection of organophosphorylated butyrylcholinesterase: A biomarker of exposure to organophosphate agents." Analytica Chimica Acta 693(1-2):1-6. 
  • Wang L, D Lu, J Wang, D Du, Z Zou, H Wang, JN Smith, C Timchalk, F Liu, and Y Lin. 2011. "A Novel Immunochromatographic Electrochemical Biosensor for Highly Sensitive and Selective Detection of Trichloropyridinol, a Biomarker of Exposure to Chlorpyrifos." Biosensors and Bioelectronics 26(6):2835-2840 .  doi:10.1016/j.bios.2010.11.008


  • Busby-Hjerpe AL, JA Campbell, JN Smith, S Lee, TS Poet, D Barr, and C Timchalk. 2010. "Comparative Pharmacokinetics of Chlorpyrifos versus its Major Metabolites Following Oral Administration in the Rat." Toxicology 268(1-2):55-63.  doi:10.1016/j.tox.2009.11.022
  • Lee S, TS Poet, JN Smith, AL Busby-Hjerpe, and C Timchalk. 2010. "Effect of In Vivo Nicotine Exposure on Chlorpyrifos Pharmacokinetics and Pharmacodynamics in Rats ." Chemico-Biological Interactions 184(3):449-457. 
  • Lee SK, TS Poet, JN Smith, AL Busby-Hjerpe, and C Timchalk. 2010. "Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats." Chemico-Biological Interactions 184(3):449-457.  doi:10.1016/j.cbi.2010.01.024
  • Smith JN, J Wang, Y Lin, and C Timchalk. 2010. "Pharmacokinetics of the Chlorpyrifos Metabolite 3,5,6-Trichloro-2-Pyridinol (TCPy) in Rat Saliva." Toxicological Sciences 132(2):315-325. 
  • Zou Z, D Du, J Wang, JN Smith, C Timchalk, YQ Li, and Y Lin. 2010. "Quantum Dot-Based Immunochromatographic Fluorescent Biosensor for Biomonitoring Trichloropyridinol, a Biomarker of Exposure to Chlorpyrifos." Analytical Chemistry 82(12):5125-5133.  doi:10.1021/ac100260m


  • Du D, J Wang, JN Smith, C Timchalk, and Y Lin. 2009. "Biomonitoring of Organophosphorus Agent Exposure by Reactivation of Cholinesterase Enzyme Based on Carbon Nanotube-Enhanced Flow-Injection Amperometric Detection ." Analytical Chemistry 81(22):9314-9320. 
  • Smith JN, JA Campbell, AL Busby-Hjerpe, S Lee, TS Poet, D Barr, and C Timchalk. 2009. "Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat." Toxicology 261(1-2):47-58.  doi:10.1016/j.tox.2009.04.041

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