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Fundamental and Computational Sciences Directorate

Staff information

Justin Teeguarden

Chem Bio & Exposure Sci Team
Biomedical Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352

PNNL Publications

2018

  • Thomas D.G., J.N. Smith, B.D. Thrall, D.R. Baer, H.D. Jolley, P. Munusamy, and V.K. Kodali, et al. 2018. "ISD3: A Particokinetic Model for Predicting the Combined Effects of Particle Sedimentation, Diffusion and Dissolution on Cellular Dosimetry for In Vitro Systems." Particle and Fibre Toxicology 15. PNNL-SA-125563. doi:10.1186/s12989-018-0243-7

2017

  • Davie-Martin C.L., K.G. Stratton, J.G. Teeguarden, K.M. Waters, and S.L. Massey Simonich. 2017. "Implications of bioremediation of polycyclic aromatic hydrocarbon-contaminated soils for human health and cancer risk." Environmental Science & Technology 51, no. 17:9458-9468. PNNL-SA-122323. doi:10.1021/acs.est.7b02956
  • Knecht A., L. Truong, S.W. Marvel, D. Reif, A. Garcia, C. Lu, and M. Simonich, et al. 2017. "Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish." Toxicology and Applied Pharmacology 329. PNNL-SA-127160. doi:10.1016/j.taap.2017.05.033
  • Ma J., C.P. Casey, X. Zheng, Y.M. Ibrahim, C.S. Wilkins, R.S. Renslow, and D.G. Thomas, et al. 2017. "PIXiE: An Algorithm for Automated Ion Mobility Arrival Time Extraction and Collision Cross Section Calculation using Global Data Association." Bioinformatics 33, no. 17:2715-2722. PNNL-SA-122828. doi:10.1093/bioinformatics/btx305
  • Metz T.O., E.M. Baker, E.L. Schymanski, R.S. Renslow, D.G. Thomas, T.J. Causon, and I.K. Webb, et al. 2017. "Integrating Ion Mobility Spectrometry into Mass Spectrometry-based Exposome Measurements: What Can It Add and How Far Can It Go?." Bioanalysis 9, no. 1:81-98. PNNL-SA-121158. doi:10.4155/bio-2016-0244

2016

  • Kabilan S., S.R. Suffield, K.P. Recknagle, R.E. Jacob, D.R. Einstein, A.P. Kuprat, and J.P. Carson, et al. 2016. "Computational Fluid Dynamics Modeling of Bacillus anthracis Spore Deposition in Rabbit and Human Respiratory Airways." Journal of Aerosol Science 99. PNNL-SA-108616. doi:10.1016/j.jaerosci.2016.01.011
  • Teeguarden J.G., Y. Tan, S. Edwards, J.A. Leonard, K. Anderson, R.A. Corley, and M.L. Kile, et al. 2016. "Expanding on Successful Concepts, Models, and Organization." Environmental Science & Technology 50, no. 17:8921-8922. PNNL-SA-119240. doi:10.1021/acs.est.6b03027
  • Teeguarden J.G., Y. Tan, Y. Tan, S. Edwards, J.A. Leonard, K.A. Anderson, and R.A. Corley, et al. 2016. "Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework." Environmental Science & Technology 50, no. 9:4579-4586. PNNL-SA-114098. doi:10.1021/acs.est.5b05311
  • Zhang X., M.V. Romm, X. Zheng, E.M. Zink, Y. Kim, K.E. Burnum-Johnson, and D.J. Orton, et al. 2016. "SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in bio?uids." Clinical Mass Spectrometry 2. PNNL-SA-117436. doi:10.1016/j.clinms.2016.11.002

2015

  • Corley R.A., S. Kabilan, A.P. Kuprat, J.P. Carson, R.E. Jacob, K.R. Minard, and J.G. Teeguarden, et al. 2015. "COMPARATIVE RISKS OF ALDEHYDE CONSTITUENTS IN CIGARETTE SMOKE USING TRANSIENT COMPUTATIONAL FLUID DYNAMICS/PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS OF THE RAT AND HUMAN RESPIRATORY TRACTS." Toxicological Sciences 146, no. 1:65-88. PNNL-SA-106531. doi:10.1093/toxsci/kfv071

2014

  • Cohen J., J.G. Teeguarden, and P. Demokritou. 2014. "An integrated approach for the in vitro dosimetry of engineered nanomaterials." Particle and Fibre Toxicology 11. PNNL-SA-106412. doi:10.1186/1743-8977-11-20
  • LaKind J.S., J.R. Sobus, M. Goodman, D.B. Barr, P. Furst, R.J. Albertini, and T.E. Arbuckle, et al. 2014. "A Proposal for Assessing Study Quality: Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals (BEES-C) Instrument." Environment International 73. PNWD-SA-10307. doi:10.1016/j.envint.2014.07.011
  • Larson J.K., M.J. Carvan, J.G. Teeguarden, G. Watanabe, K. Taya, E. Krystofiak, and R.J. Hutz. 2014. "Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress." Nanotoxicology 8, no. 8:856-66. PNNL-SA-101177. doi:10.3109/17435390.2013.837208
  • Teeguarden J.G., V.B. Mikheev, K.R. Minard, W.C. Forsythe, W. Wang, G. Sharma, and N.J. Karin, et al. 2014. "Comparative Iron Oxide Nanoparticle Cellular Dosimetry and Response in Mice by the Inhalation and Liquid Cell Culture Exposure Routes." Particle and Fibre Toxicology 11. PNNL-SA-101188. doi:10.1186/s12989-014-0046-4

2013

  • DeWoskin R.D., L.M. Sweeney, J.G. Teeguarden, R. Sams, and J. Vandenberg. 2013. "Comparison of PBTK Model and Biomarker Based Estimates of the Internal Dosimetry of Acrylamide." Food and Chemical Toxicology 58. PNWD-SA-9921. doi:10.1016/j.fct.2013.05.008
  • Kodali V.K., M.H. Littke, S.C. Tilton, J.G. Teeguarden, L. Shi, C.W. Frevert, and W. Wang, et al. 2013. "Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles." ACS Nano 7, no. 8:6997-7010. PNNL-SA-95359. doi:10.1021/nn402145t
  • Minard K.R., M.H. Littke, W. Wang, Y. Xiong, J.G. Teeguarden, and B.D. Thrall. 2013. "Magnetic Particle Detection (MPD) for In-Vitro Dosimetry." Biosensors and Bioelectronics 43. PNNL-SA-90647. doi:10.1016/j.bios.2012.12.011
  • Shankaran H., F. Adeshina, and J.G. Teeguarden. 2013. "Physiologically-Based Pharmacokinetic Model for Fentanyl in Support of the Development of Provisional Advisory Levels." Toxicology and Applied Pharmacology 273, no. 13:002464-476. PNWD-SA-10008. doi:10.1016/j.taap.2013.05.024
  • Sharma G., V.K. Kodali, M.J. Gaffrey, W. Wang, K.R. Minard, N.J. Karin, and J.G. Teeguarden, et al. 2013. "Iron Oxide Nanoparticle Agglomeration Influences Dose-Rates and Modulates Oxidative Stress Mediated Dose-Response Profiles In Vitro." Nanotoxicology 8, no. 6:663-675. PNNL-SA-93447. doi:10.3109/17435390.2013.822115
  • Teeguarden J.G., and S. Hanson-Drury. 2013. "A Systematic Review of Bisphenol A “Low Dose” Studies in the Context of Human Exposure: A Case for Establishing Standards for Reporting “Low- Dose” Effects of Chemicals." Food and Chemical Toxicology 62. PNWD-SA-10180. doi:10.1016/j.fct.2013.07.007
  • Teeguarden J.G., C. Housand, J.N. Smith, P.M. Hinderliter, R. Gunawan, and C. Timchalk. 2013. "A Multi-Route Model of Nicotine-Cotinine Pharmacokinetics, Pharmacodynamics and Brain Nicotinic Acetylcholine Receptor Binding in Humans." Regulatory Toxicology and Pharmacology 65, no. 1:12-28. PNNL-SA-92151. doi:10.1016/J.YRTPH.2012.10.007
  • Teeguarden J.G., J. Fisher, and D.R. Doerge. 2013. "Exposure Conditions and Pharmacokinetic Principles: Interpreting Bisphenol A Absorption in the Canine Oral Cavity." Environmental Health Perspectives 121, no. 11-12:A323-A323. PNWD-SA-10183. doi:10.1289/ehp.1307424
  • Teeguarden J.G., S. Hanson-Drury, J.W. Fisher, and D.R. Doerge. 2013. "Are Typical Human Serum BPA Concentrations Measureable and Sufficient to be Estrogenic in the General Population?." Food and Chemical Toxicology 62. PNWD-SA-10192. doi:10.1016/j.fct.2013.08.001

2012

  • Karakoti A.S., P. Munusamy, K.E. Hostetler, V.K. Kodali, S.N. Kuchibhatla, G. Orr, and J.G. Pounds, et al. 2012. "Preparation and Characterization Challenges to Understanding Environmental and Biological Impacts of Ceria Nanoparticles." Surface and Interface Analysis 44, no. 8:881-889. PNNL-SA-83765. doi:10.1002/sia.5006
  • Teeguarden J.G., A. Calafat, and D.R. Doerge. 2012. "Adhering to Fundamental Principles of Biomonitoring, BPA Pharmacokinetics, and Mass Balance is no "Flaw"." Toxicological Sciences 125, no. 1:321-325. PNWD-SA-9573. doi:10.1093/toxsci/kfr275
  • Thrall B.D., K.R. Minard, J.G. Teeguarden, and K.M. Waters. 2012. Multiscale Toxicology - Building the Next Generation Tools for Toxicology. PNNL-21916. Richland, WA: Pacific Northwest National Laboratory.
  • Xie Y., N.G. Williams, A. Tolic, W.B. Chrisler, J.G. Teeguarden, B.L. Maddux, and J.G. Pounds, et al. 2012. "Aerosolized ZnO nanoparticles induce toxicity in alveolar type II epithelial cells at the air-liquid interface." Toxicological Sciences 125, no. 2:450-461. PNNL-SA-83610. doi:10.1093/toxsci/kfr251

2011

  • Baer D.R., A.S. Karakoti, P. Munusamy, B.D. Thrall, J.G. Pounds, J.G. Teeguarden, and J.E. Amonette, et al. 2011. "Testing in EHS: What is the Current Status of Experimentation?." In 11th IEEE International Conference on Nanotechnology (IEEE-NANO 2011), August 15-18, 2011, Portland, Oregon, 18-19. Piscataway, New Jersey:IEEE. PNNL-SA-90027. doi:10.1109/NANO.2011.6144671
  • Hanns-Rudolf P., F.R. Cassee, J.G. Teeguarden, H. Fissan, S. Diabate, M. Aufderheide, and W.G. Kreyling, et al. 2011. "In-vitro Cell Exposure Studies for the Assessment of Nanoparticle Toxicity in the Lung - A Dialogue between Aerosol Science and Biology." Journal of Aerosol Science 42, no. 10:668-692. PNNL-SA-75727. doi:10.1016/j.jaerosci.2011.06.005
  • Teeguarden J.G., A. Calafat, X. Ye, D.R. Doerge, M.I. Churchwell, R. Gunawan, and M.K. Graham. 2011. "Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure." Toxicological Sciences 123, no. 1:48-57. PNWD-SA-9583. doi:10.1093/toxsci/kfr160
  • Teeguarden J.G., B.M. Webb-Robertson, K.M. Waters, A. Murray, E. Kisin, S.M. Varnum, and J.M. Jacobs, et al. 2011. "Comparative Proteomics and Pulmonary Toxicity of Instilled Single Walled Carbon Nanotubes, Crocidolite Asbestos and Ultrafine Carbon Black in Mice." Toxicological Sciences 120, no. 1:123-135. PNNL-SA-74369. doi:10.1093/toxsci/kfq363

2010

  • Hinderliter P.M., K.R. Minard, G. Orr, W.B. Chrisler, B.D. Thrall, J.G. Pounds, and J.G. Teeguarden. 2010. "ISDD: A Computational Model of Particle Sedimentation, Diffusion and Target Cell Dosimetry for In Vitro Toxicity Studies." Particle and Fibre Toxicology 7, no. November:Article No. 36. PNNL-SA-74873. doi:10.1186/1743-8977-7-36

2009

  • Crump K.S., and J.G. Teeguarden. 2009. "Benchmark calculations from summarized data: an example." Environmental and Ecological Statistics 16, no. 1:13-24. PNNL-SA-62810.
  • Waters K.M., L.M. Masiello, R.C. Zangar, B.J. Tarasevich, N.J. Karin, R.D. Quesenberry, and S. Bandyopadhyay, et al. 2009. "Macrophage Responses to Silica Nanoparticles are Highly Conserved Across Particle Sizes." Toxicological Sciences 107, no. 2:553-569. PNNL-SA-62659.

2008

  • Teeguarden J.G., A. Gupta, P. Escobar, and M. Jackson. 2008. "Toxicology steps up to nanotechnology safety." Research & Development 50, no. 1:28-29. PNWD-SA-7902.
  • Teeguarden J.G., M.S. Bogdanffy, T.R. Covington, C. Tan, C. Tan, and A.M. Jarabek. 2008. "A PBPK Model for Evaluating the Impact of Aldehyde Dehydrogenase Polymorphisms on Comparative Rat and Human Nasal Tissue Acetaldehyde Dosimetry." Inhalation Toxicology 20, no. 4:375-390. PNWD-SA-8034. doi:10.1080/08958370801903750

2007

  • Dutta D., S.K. Sundaram, J.G. Teeguarden, B.J. Riley, L.S. Fifield, J.M. Jacobs, and R.S. Addleman, et al. 2007. "Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials." Toxicological Sciences 100, no. 1:303-315. PNNL-SA-55139. doi:10.1093/toxsci/kfm217
  • Orr G., D.J. Panther, J.L. Phillips, B.J. Tarasevich, A. Dohnalkova, D. Hu, and J.G. Teeguarden, et al. 2007. "Submicron and Nanoscale Inorganic Particles Exploit the Actin Machinery to be Propelled Along Microvillilike Structures into Alveolar Cells." ACS Nano 1, no. 5:463-475. PNNL-SA-53625. doi:10.1021/nn700149r
  • Teeguarden J.G., D.C. Dorman, A. Nong, T.R. Covington, H.J. Clewell, III, and M.E. Andersen. 2007. "Pharmacokinetic Modeling of Manganese II. Hepatic Processing after Ingestion and Inhalation." Journal of Toxicology and Environmental Health Part A 70, no. 18:1505-1514. PNWD-SA-7554. doi:10.1080/15287390701384619
  • Teeguarden J.G., D.C. Dorman, T.R. Covington, H.J. Clewell, III, and M.E. Andersen. 2007. "Pharmacokinetic Modeling of Manganese I. Dose-Dependencies of Uptake and Elimination." Journal of Toxicology and Environmental Health Part A 70, no. 18:1493-1504. PNWD-SA-7553. doi:10.1080/15287390701384601
  • Teeguarden J.G., J. Gearhart, H.J. Clewell, III, T.R. Covington, A. Nong, and M.E. Anderson. 2007. "Pharmacokinetic Modeling of Manganese III. Physiological Approaches Accounting for Background and Tracer Kinetics." Journal of Toxicology and Environmental Health Part A 70, no. 18:1515-1526. PNNL-SA-52194. doi:10.1080/15287390701384635
  • Teeguarden J.G., P.M. Hinderliter, G. Orr, B.D. Thrall, and J.G. Pounds. 2007. "Particokinetics In Vitro: Dosimetry Considerations for In Vitro Nanoparticle Toxicity Assessments." Toxicological Sciences 95, no. 2:300-312. PNNL-SA-55055. doi:10.1093/toxsci/kfl165

2005

  • Teeguarden J.G., J.M. Waechter, H.J. Clewell, III, T.R. Covington, and H.A. Barton. 2005. "Evaluation of Oral and IntravenousRoute Pharmacokinetics, Plasma Protein Binding and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach." Toxicological Sciences 85, no. 2:823-838. PNWD-SA-6845. doi:10.1093/toxsci/kfil135
  • Teeguarden J.G., P.J. Deisinger, T.S. Poet, J.C. English, W.D. Faber, H.A. Barton, and R.A. Corley, et al. 2005. "Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid." Toxicological Sciences 85, no. 1:429-446. PNNL-SA-42701.

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