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Fundamental and Computational Sciences Directorate

Staff information

Jon Jacobs

Biomedical Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352

PNNL Publications


  • Moghieb A.M., L. Tesfay, S. Nie, M.A. Gritsenko, T.L. Fillmore, J.M. Jacobs, and R.D. Smith, et al. 2019. "A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification." Scientific Reports 9, no. 1:Article No. 7264. PNNL-SA-138022. doi:10.1038/s41598-019-43756-9


  • Kedia K., J.P. Wendler, E.M. Baker, K.E. Burnum-Johnson, L.G. Jarsberg, K.G. Stratton, and A.T. Wright, et al. 2018. "Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis." Tuberculosis 112. PNNL-SA-137966. doi:10.1016/


  • Liberton M.L., W.B. Chrisler, C.D. Nicora, R.J. Moore, R.D. Smith, D.W. Koppenaal, and H.B. Pakrasi, et al. 2017. "Phycobilisome Truncation Causes Widespread Proteome Changes in Synechocystis sp. PCC 6803." PLoS One 12, no. 3:e0173251. PNNL-SA-112677. doi:10.1371/journal.pone.0173251
  • Nielson C., J. Wiedrick, J. Shen, J.M. Jacobs, E.M. Baker, A. Baraff, and P.D. Piehowski, et al. 2017. "Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics." Journal of Bone and Mineral Research 32, no. 7:1559-1567. PNNL-SA-111322. doi:10.1002/jbmr.3125


  • Hiras J., Y. Wu, K. Deng, C.D. Nicora, J.T. Aldrich, D. Frey, and S. Kolinko, et al. 2016. "Comparative community proteomics demonstrates the unexpected importance of an actinobacterial glycoside hydrolase family 12 protein for crystalline cellulose hydrolysis." mBio 7, no. 4:Article No. e01106-16. PNNL-SA-120275. doi:10.1128/mBio.01106-16
  • Liberton M.L., R. Saha, J.M. Jacobs, A.Y. Nguyen, M.A. Gritsenko, R.D. Smith, and D.W. Koppenaal, et al. 2016. "Global Proteomic Analysis Reveals an Exclusive Role of Thylakoid Membranes in Bioenergetics of a Model Cyanobacterium." Molecular and Cellular Proteomics 15, no. 6:2021-2032. PNNL-SA-121062. doi:10.1074/mcp.M115.057240
  • Liberton M.L., R. Saha, J.M. Jacobs, A.Y. Nguyen, M.A. Gritsenko, R.D. Smith, and D.W. Koppenaal, et al. 2016. "Proteomics analysis of isolated plasma membrane and thylakoid membrane from Synechocystis sp. PCC 6803." Molecular and Cellular Proteomics 15, no. 6:2021-2032. PNNL-SA-112674. doi:10.1074/mcp.M115.057240
  • Nakayasu E.S., C.D. Nicora, A.C. Sims, K.E. Burnum-Johnson, Y. Kim, J.E. Kyle, and M.M. Matzke, et al. 2016. "MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses." mSystems 1, no. 3:e00043-16. PNNL-SA-114737. doi:10.1128/mSystems.00043-16
  • Nielson C., K. Jones, R.F. Chun, J.M. Jacobs, Y. Wang, M. Hewison, and J.S. Adams, et al. 2016. "Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations." Journal of Clinical Endocrinology and Metabolism 101, no. 5:2226-2234. PNNL-SA-120076. doi:10.1210/jc.2016-1104
  • Nielson C., K. Jones, R.F. Chun, J.M. Jacobs, Y. Wang, M. Hewison, and J.S. Adams, et al. 2016. "Role of Assay Type in Determining Free 25-Hydroxyvitamin D Levels in Diverse Populations." The New England Journal of Medicine 374, no. 17:1695-1696. PNNL-SA-108708. doi:10.1056/NEJMc1513502
  • Oxford K.L., J.P. Wendler, J.E. McDermott, R.A. White, J.D. Powell, J.M. Jacobs, and J.N. Adkins, et al. 2016. "The Landscape of Viral Proteomics and Its Potential to Impact Human Health." Expert Review of Proteomics 13, no. 6:579-591. PNNL-SA-116259. doi:10.1080/14789450.2016.1184091


  • Yu J., M.L. Liberton, P. Cliften, R. Head, J.M. Jacobs, R.D. Smith, and D.W. Koppenaal, et al. 2015. "Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2." Scientific Reports 5. PNNL-SA-105375. doi:10.1038/srep08132


  • Aevermann B., B.E. Pickett, S. Kumar, E.B. Klem, S. Agnihothram, P.S. Askovich, and A. Bankhead, et al. 2014. "A Comprehensive Collection of Systems Biology Data Characterizing the Host Response to Viral Infection." Scientific Data 1. PNNL-SA-101269. doi:10.1038/sdata.2014.33
  • Baker E.S., K.E. Burnum-Johnson, J.M. Jacobs, D.L. Diamond, R.N. Brown, Y.M. Ibrahim, and D.J. Orton, et al. 2014. "Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry." Molecular and Cellular Proteomics 13, no. 4:1119-1127. PNNL-SA-90826. doi:10.1074/mcp.M113.034595
  • Dominy S., J.N. Brown, M.I. Ryder, M.A. Gritsenko, J.M. Jacobs, and R.D. Smith. 2014. "Proteomic Analysis of Saliva in HIV-positive Heroin Addicts Reveals Proteins Correlated with Cognition." PLoS One 9, no. 4:e89366. PNNL-SA-95909. doi:10.1371/journal.pone.0089366
  • Govey P.M., J.M. Jacobs, S.C. Tilton, A.E. Loiselle, Y. Zhang, W.M. Freeman, and K.M. Waters, et al. 2014. "Integrative Transcriptomic and Proteomic Analysis of Osteocytic Cells Exposed to Fluid Flow Reveals Novel Mechano-Sensitive Signaling Pathways." Journal of Biomechanics 47, no. 8:1838-1845. PNWD-SA-10062. doi:10.1016/j.jbiomech.2014.03.022
  • Welkie D.G., X. Zhang, L.M. Markillie, R.C. Taylor, G. Orr, J.M. Jacobs, and K. Bhide, et al. 2014. "Transcriptomic and proteomic dynamics in the metabolism of a diazotrophic cyanobacterium, Cyanothece sp. PCC 7822 during a diurnal light-dark cycle." BMC Genomics 15. PNNL-SA-104956.


  • Price R.W., J. Peterson, D. Fuchs, T.E. Angel, H. Zetterberg, L. Hagberg, and S.S. Spudich, et al. 2013. "Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection." Journal of Neuroimmune Pharmacology 8, no. 5:1147-1158. PNNL-SA-98546. doi:10.1007/s11481-013-9491-3
  • Wang J., B.M. Webb-Robertson, M.M. Matzke, S.M. Varnum, J.N. Brown, R.M. Riensche, and J.N. Adkins, et al. 2013. "A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification." Disease Markers 35, no. 5:513-523. PNNL-SA-94068. doi:10.1155/2013/613529


  • Angel T.E., J.M. Jacobs, R.P. Smith, M.S. Pasternack, S. Elias, M.A. Gritsenko, and A.K. Shukla, et al. 2012. "Cerebrospinal Fluid Proteome of Patients with Acute Lyme Disease." Journal of Proteome Research 11, no. 10:4814-4822. PNNL-SA-79143. doi:10.1021/pr300577p
  • Angel T.E., J.M. Jacobs, S.S. Spudich, M.A. Gritsenko, D. Fuchs, T. Liegler, and H. Zetterberg, et al. 2012. "The cerebrospinal fluid proteome in HIV infection: change associated with disease severity." Clinical Proteomics 9. PNNL-SA-81597. doi:10.1186/1559-0275-9-3
  • Aryal U.K., J. Stockel, E.A. Welsh, M.A. Gritsenko, C.D. Nicora, D.W. Koppenaal, and R.D. Smith, et al. 2012. "Dynamic proteome analysis of Cyanothece sp. ATCC 51142 under constant light." Journal of Proteome Research 11, no. 2:609-619. PNNL-SA-80375. doi:10.1021/pr200959x
  • Brown J.N., G.M. Ortiz, T.E. Angel, J.M. Jacobs, M.A. Gritsenko, E.Y. Chan, and D.E. Purdy, et al. 2012. "Morphine Produces Immunosuppressive Effects in Non-human Primates at the Proteomic and Cellular Levels." Molecular & Cellular Proteomics. MCP 11, no. 9:605-618. PNNL-SA-83778. doi:10.1074/mcp.M111.016121
  • Diamond D.L., A. Krasnoselski, K.E. Burnum, M.E. Monroe, B.M. Webb-Robertson, J.E. McDermott, and M.M. Yeh, et al. 2012. "Proteome and Computational Analyses Reveal New Insights into the Mechanisms of Hepatitis C Virus Mediated Liver Disease Posttransplantation." Hepatology 56, no. 1:28-38. PNWD-SA-9552. doi:10.1002/hep.25649


  • Aryal U.K., J. Stockel, R.K. Krovvidi, M.A. Gritsenko, M.E. Monroe, R.J. Moore, and D.W. Koppenaal, et al. 2011. "Dynamic proteomic profiling of a unicellular cyanobacterium Cyanothece ATCC51142 across light-dark diurnal cycles." BMC Systems Biology 5. PNNL-SA-81418. doi:10.1186/1752-0509-5-194
  • Dresang L.R., J.R. Teuton, H. Feng, J.M. Jacobs, D.G. Camp, S.O. Purvine, and M.A. Gritsenko, et al. 2011. "Coupled Transcriptome and Proteome Analysis of Human Lymphotropic Tumor Viruses: Insights on the Detection and Discovery of Viral Genes." BMC Genomics 12. PNNL-SA-84775. doi:10.1186/1471-2164-12-625
  • Matzke M.M., K.M. Waters, T.O. Metz, J.M. Jacobs, A. Sims, R. Baric, and J.G. Pounds, et al. 2011. "Improved Quality Control Processing of Peptide-centric LC-MS Proteomics Data." Bioinformatics 27, no. 20:2866-2872. PNNL-SA-76540.
  • Stockel J., J.M. Jacobs, T.R. Elvitigala, M.L. Liberton, E.A. Welsh, A.D. Polpitiya, and M.A. Gritsenko, et al. 2011. "Diurnal Rhythms Result in Significant Changes in the Cellular Protein Complement in the Cyanobacterium Cyanothece 51142." PLoS One 6, no. 2:Article No.: e16680. PNNL-SA-78209. doi:10.1371/journal.pone.0016680
  • Teeguarden J.G., B.M. Webb-Robertson, K.M. Waters, A. Murray, E. Kisin, S.M. Varnum, and J.M. Jacobs, et al. 2011. "Comparative Proteomics and Pulmonary Toxicity of Instilled Single Walled Carbon Nanotubes, Crocidolite Asbestos and Ultrafine Carbon Black in Mice." Toxicological Sciences 120, no. 1:123-135. PNNL-SA-74369. doi:10.1093/toxsci/kfq363
  • Wang Y., F. Yang, Y. Fu, X. Huang, W. Wang, X. Jiang, and M.A. Gritsenko, et al. 2011. "Spatial Phosphoprotein Profiling Reveals a Compartmentalized Extracellular Signal-regulated Kinase Switch Governing Neurite Growth and Retraction." Journal of Biological Chemistry 286, no. 20:18190-18201. PNNL-SA-79165.
  • Waters K.M., J.M. Jacobs, M.A. Gritsenko, and N.J. Karin. 2011. "Regulation of gene expression and subcellular protein distribution in MLO-Y4 osteocytic cells by lysophosphatidic acid: Relevance to dendrite outgrowth." Bone 48, no. 6:1328-35. PNNL-SA-74808. doi:10.1016/j.bone.2011.02.020
  • Webb-Robertson B.M., M.M. Matzke, J.M. Jacobs, J.G. Pounds, and K.M. Waters. 2011. "A Statistical Selection Strategy for Normalization Procedures in LC-MS Proteomics Experiments through Dataset Dependent Ranking of Normalization Scaling Factors." Proteomics 11, no. 24:4736-4741. PNNL-SA-78392. doi:10.1002/pmic.201100078


  • Angel T.E., B.J. Luft, X. Yang, C.D. Nicora, D.G. Camp, J.M. Jacobs, and R.D. Smith. 2010. "Proteome Analysis of Borrelia burgdorferi Response to Environmental Change." PLoS One 5, no. 11:Article No.: e13800. PNNL-SA-74148. doi:10.1371/journal.pone.0013800
  • Brown J.N., R. Palermo, C.R. Baskin, M.A. Gritsenko, P.J. Sabourin, P.J. Sabourin, and J.P. Long, et al. 2010. "Macaque Proteome Response to Highly Pathogenic Avian Influenza and 1918 Reassortant Influenza Virus Infections." Journal of Virology 84, no. 22:12058-12068. PNWD-SA-9238.
  • Diamond D.L., A.J. Syder, J.M. Jacobs, C.M. Sorensen, K. Walters, S. Proll, and J.E. McDermott, et al. 2010. "Temporal Proteome and Lipidome Profiles Reveal HCV-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics." PLoS Pathogens 6, no. 1:Art. No. e1000719. PNWD-SA-8678. doi:10.1371/journal.ppat.1000719
  • Webb-Robertson B.M., L.A. McCue, K.M. Waters, M.M. Matzke, J.M. Jacobs, T.O. Metz, and S.M. Varnum, et al. 2010. "Combined Statistical Analyses of Peptide Intensities and Peptide Occurrences Improves Identification of Significant Peptides from MS-based Proteomics Data." Journal of Proteome Research 9, no. 11:5748-5756. PNNL-SA-72886.
  • Wegener K.M., A.K. Singh, J.M. Jacobs, T.R. Elvitigala, E.A. Welsh, N.S. Keren, and M.A. Gritsenko, et al. 2010. "Global Proteomics Reveal An Atypical Strategy for Carbon/Nitrogen Assimilation by a Cyanobacterium Under Diverse Environmental Perturbations." Molecular & Cellular Proteomics. MCP 9, no. 12:2678-89. PNNL-SA-67041. doi:10.1074/mcp.M110.000109
  • Zhang X., M.E. Monroe, B. Chen, M.H. Chin, T.H. Heibeck, A.A. Schepmoes, and F. Yang, et al. 2010. "Endogenous 3, 4- Dihydroxyphenylalanine and Dopaquinone Modifications on Protein Tyrosine: links to mitochondrially derived oxidative stress via hydroxyl radical." Molecular & Cellular Proteomics. MCP 9, no. 6:1199-1208. PNNL-SA-65899.


  • Chan E.Y., J.N. Sutton, J.M. Jacobs, A. Bondarenko, R.D. Smith, and M.G. Katze. 2009. "Dynamic Host Energetics and Cytoskeletal Proteomes in HIV-1 -Infected Human Primary CD4 Cells: Analysis by Multiplexed Label-free Mass Spectrometry." Journal of Virology 83, no. 18:9283-9295. PNWD-SA-8677.


  • Ding S., Y. Wang, J.M. Jacobs, W. Qian, F. Yang, A.V. Tolmachev, and X. Du, et al. 2008. "Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid Induced Chemotaxis applying Dual-step 18O Labeling Coupled with Immobilized Metal-ion Affinity Chromatography." Journal of Proteome Research 7, no. 10:4215-24. PNNL-SA-52241. doi:10.1021/pr7007785
  • Dumortier J., D.N. Streblow, A.V. Moses, J.M. Jacobs, C.N. Kreklywich, D.G. Camp, and R.D. Smith, et al. 2008. "Human Cytomegalovirus Secretome Contains Factors That Induce Angiogenesis and Wound Healing." Journal of Virology 82, no. 13:6524-6535. PNNL-SA-60994. doi:doi:10.1128/JVI.00502-08
  • Jacobs J.M., K.M. Waters, L.E. Kathmann, D.G. Camp, H.S. Wiley, R.D. Smith, and B.D. Thrall. 2008. "The Mammary Epithelial Cell Secretome and its Regulation by Signal Transduction Pathways." Journal of Proteome Research 7, no. 2:558-569. PNNL-SA-56310. doi:10.1021/pr0704377
  • Metz T.O., W. Qian, J.M. Jacobs, M.A. Gritsenko, R.J. Moore, A.D. Polpitiya, and M.E. Monroe, et al. 2008. "Application of proteomics in the discovery of candidate protein biomarkers in a Diabetes Autoantibody Standardization Program sample subset." Journal of Proteome Research 7, no. 2:698-707. PNNL-SA-56533. doi:10.1021/pr700606w
  • Pasa-Tolic L., J.M. Jacobs, W. Qian, and R.D. Smith. 2008. "Quantitative Proteomics using Nano-LC with High Accuracy Mass Spectrometry." In Clinical Proteomics: From Diagnosis to Therapy, edited by JE Van Eyk and MJ Dunn. 89-100. Weinheim:Wiley-VCH. PNNL-SA-51867.
  • Wegener K.M., E.A. Welsh, L.E. Thornton, N.S. Keren, J.M. Jacobs, K.K. Hixson, and M.E. Monroe, et al. 2008. "High Sensitivity Proteomics Assisted Discovery of a Novel Operon Involved in the Assembly of Photosystem II, a Membrane Protein Complex." Journal of Biological Chemistry 283, no. 41:27829-27837. PNNL-SA-57538. doi:10.1074/jbc.M803918200
  • Welsh E.A., M.L. Liberton, J. Stockel, T. Loh, T.R. Elvitigala, C. Wang, and A. Wollam, et al. 2008. "The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle." Proceedings of the National Academy of Sciences of the United States of America 105, no. 39:15094-15099. PNNL-SA-56846. doi:10.1073/pnas.0805418105


  • Diamond D.L., J.M. Jacobs, B. Paeper, S. Proll, M.A. Gritsenko, R.L. Carithers, Jr., and A.M. Larson, et al. 2007. "Proteomic Profiling of Human Liver Biopsies: Hepatitis C Virus-Induced Fibrosis and Mitochondrial Dysfunction." Hepatology 46, no. 3:649-657. PNWD-SA-7685. doi:10.1002/hep.21751
  • Dutta D., S.K. Sundaram, J.G. Teeguarden, B.J. Riley, L.S. Fifield, J.M. Jacobs, and R.S. Addleman, et al. 2007. "Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials." Toxicological Sciences 100, no. 1:303-315. PNNL-SA-55139. doi:10.1093/toxsci/kfm217
  • Metz T.O., Q. Zhang, J.S. Page, Y. Shen, S.J. Callister, J.M. Jacobs, and R.D. Smith. 2007. "The future of liquid chromatography-mass spectrometry in metabolic profiling and metabolomic studies for biomarker discovery." Biomarkers in Medicine 1, no. 1:159-185. PNNL-SA-53806.
  • Wang Y., S. Ding, W. Wang, F. Yang, J.M. Jacobs, D.G. Camp, and R.D. Smith, et al. 2007. "Methods for Pseudopodia Purification and Proteomic Analysis." Sciences STKE Signal Transduction Knowledge Environment 2007, no. 400:p14. PNNL-SA-56168.
  • Wang Y., S. Ding, W. Wang, J.M. Jacobs, W. Qian, R.J. Moore, and F. Yang, et al. 2007. "Profiling Signaling Polarity in Chemotactic Cells." Proceedings of the National Academy of Sciences of the United States of America 104, no. 20:8328-8333. PNNL-SA-51866. doi:10.1073/pnas.0701103104


  • Baas T., C.R. Baskin, D.L. Diamond, A. Garcia-Sastre, H. Bielefeldt-Ohmann, T.M. Tumpey, and M.J. Thomas, et al. 2006. "Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Proteomics." Journal of Virology 80, no. 21:10813 (16 pages). PNWD-SA-7379. doi:10.1128/JVI.00851-06
  • Diamond D.L., S. Proll, J.M. Jacobs, E.Y. Chan, D.G. Camp, R.D. Smith, and M.G. Katze. 2006. "HepatoProteomics: Applying Proteomic Technologies to the Study of Liver Function and Disease." Hepatology 44, no. 2:299-308. PNWD-SA-7378.
  • Jacobs J.M., and R.D. Smith. 2006. "Proteomic Analyses Using High-Efficiency Separations and Accurate Mass Measurements." In Separation Methods in Proteomics, edited by GB Smejkal and A Lazareu. 363-385. Boca Raton, Florida:CRC Taylor & Francis. PNNL-SA-42439.
  • Jacobs J.M., and R.D. Smith. 2006. "Proteomic Analyses using High-Efficiency Separations and Accurate Mass Measurements." In Separations in Proteomics, edited by Smejkal, GB and A Lazareu. 363-385. New York, New York:CRC Taylor and Francis Group. PNNL-SA-43219.
  • Metz T.O., J.M. Jacobs, M.A. Gritsenko, G. Fontes, W. Qian, D.G. Camp, and V.J. Poitout, et al. 2006. "Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS." Journal of Proteome Research 5, no. 12:3345-3354. PNNL-SA-49730. doi:10.1021/pr060322n
  • Qian W., J.M. Jacobs, T. Liu, D.G. Camp, and R.D. Smith. 2006. "Advances and Challenges in Liquid Chromatography-Mass Spectrometry-Based Proteomics Profiling for Clinical Applications." Molecular & Cellular Proteomics. MCP 5, no. 10:1727-1744. PNWD-SA-7399. doi:10.1074/mcp.M600162-MCP200


  • Adkins J.N., M.E. Monroe, K.J. Auberry, Y. Shen, J.M. Jacobs, D.G. Camp, and F. Vitzthum, et al. 2005. "A Proteomic Study of the HUPO Plasma Proteome Project's Pilot Samples using an Accurate Mass and Time Tag Strategy." Proteomics 5, no. 13:3454-3466. PNWD-SA-6982. doi:10.1002/pmic.200401333
  • Jacobs J.M., D.L. Diamond, E.Y. Chan, M.A. Gritsenko, W. Qian, M. Stastna, and T. Baas, et al. 2005. "Proteome Analysis of Liver Cells Expressing a Full- Length Hepatitis C Virus (HCV) Replicon and Biopsy Specimens of Posttransplantation Liver from HCV-Infected Patients." Journal of Virology 79, no. 12:7558-7569. PNWD-SA-6678.
  • Jacobs J.M., J.N. Adkins, W. Qian, T. Liu, Y. Shen, D.G. Camp, and R.D. Smith. 2005. "Utilizing human blood plasma for proteomic biomarker discovery." Journal of Proteome Research 4, no. 4:1073-1085. PNWD-SA-6880. doi:10.1021/pr0500657
  • Jacobs J.M., M.E. Monroe, W. Qian, Y. Shen, G.A. Anderson, and R.D. Smith. 2005. "Ultra-Sensitive, High Throughput and Quantitative Proteomics Measurements." International Journal of Mass Spectrometry 240, no. 3:195-212. PNNL-SA-42919.
  • Jacobs J.M., X. Yang, B.J. Luft, J.J. Dunn, D.G. Camp, and R.D. Smith. 2005. "Proteomic Analysis of Lyme Disease: Global Protein Comparison of Three Strains of Borrelia burgdorferi." Proteomics 5, no. 5:1446-1453. PNNL-SA-42921.
  • Liu T., W. Qian, W.U. Chen, J.M. Jacobs, R.J. Moore, D.J. Anderson, and M.A. Gritsenko, et al. 2005. "Improved Proteome Coverage by Using High Efficiency Cysteinyl-peptide Enrichment: The Human Mammary Epithelial Cell Proteome." Proteomics 5, no. 5:1263-1273. PNNL-SA-42468.
  • Qian W., J.M. Jacobs, D.G. Camp, M.E. Monroe, R.J. Moore, M.A. Gritsenko, and S.E. Calvano, et al. 2005. "Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry." Proteomics 5, no. 2:572-584. PNNL-SA-40692. doi:10.1002/pmic.200400942
  • Qian W., J.M. Jacobs, D.G. Camp, M.E. Monroe, R.J. Moore, M.A. Gritsenko, and S.E. Calvano, et al. 2005. "Comparative Proteome Analyses of Human Plasma Following in vivo Lipopolysaccharide Administration Using Multidimensional Separations Coupled with Tandem Mass Spectrometry." Proteomics 5, no. 2:572-584. PNNL-SA-41257.
  • Qian W., M.E. Monroe, T. Liu, J.M. Jacobs, G.A. Anderson, Y. Shen, and R.J. Moore, et al. 2005. "Quantitative Proteome Analysis of Human Plasma Following in vivo Lipopolysaccharide Administration using O-16/O-18 Labeling and the Accurate Mass and Time Tag Approach." Molecular & Cellular Proteomics. MCP 4, no. 5:700-709. PNNL-SA-44302.
  • Qian W., T. Liu, M.E. Monroe, E.F. Strittmatter, J.M. Jacobs, L.J. Kangas, and K. Petritis, et al. 2005. "Probability-Based Evaluation of Peptide and Protein Identifications from Tandem Mass Spectrometry and SEQUEST Analysis: The Human Proteome." Journal of Proteome Research 4, no. 1:53-62. PNNL-SA-42815.
  • Shen Y., J. Kim, E.F. Strittmatter, J.M. Jacobs, D.G. Camp, R. Fang, and N. Tolic, et al. 2005. "Characterization of the human blood plasma proteome." Proteomics 5, no. 15:4034-4045. PNWD-SA-6708.


  • Jacobs J.M., H.M. Mottaz, L. Yu, D.J. Anderson, R.J. Moore, W.U. Chen, and K.J. Auberry, et al. 2004. "Multidimensional Proteome Analysis of Human Mammary Epithelial Cells." Journal of Proteome Research 3, no. 1:68-75. PNWD-SA-6087.
  • Shen Y., J.M. Jacobs, D.G. Camp, R. Fang, R.J. Moore, R.D. Smith, and W. Xiao, et al. 2004. "Ultra-High-Efficiency Strong Cation Exchange LC/RPLC/MS/MS for High Dynamic Range Characterization of the Human Plasma Proteome." Analytical Chemistry 76, no. 4:1134-1144. PNNL-SA-39155.
  • Strittmatter E.F., L.J. Kangas, K. Petritis, H.M. Mottaz, G.A. Anderson, Y. Shen, and J.M. Jacobs, et al. 2004. "Application of Peptide LC Retention Time Information in a Discriminant Function for Peptide Identification by Tandem Mass Spectrometry." Journal of Proteome Research 3, no. 4:760-769. PNNL-SA-40693.

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