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Fundamental and Computational Sciences Directorate

Staff information

Thomas Weber

Exposure Science
Biomedical Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352

PNNL Publications


  • Jaegers N.R., W. Hu, T.J. Weber, and J.Z. Hu. 2021. "Low temperature (<200°C) degradation of electronic nicotine delivery system liquids generates toxic aldehydes." Scientific Reports 11, no. 1:Article No. 7800. PNNL-SA-153706. doi:10.1038/s41598-021-87044-x


  • Zhang T., M.J. Gaffrey, D.G. Thomas, T.J. Weber, B.M. Hess, K.K. Weitz, and P.D. Piehowski, et al. 2020. "A proteome-wide assessment of the oxidative stress paradigm for metal and metal-oxide nanomaterials in human macrophages." NanoImpact 17. PNNL-SA-147217. doi:10.1016/j.impact.2019.100194


  • Han A., C. Timchalk, Z.A. Carver, T.J. Weber, K.J. Tyrrell, R.L. Sontag, and T.M. Gibbins, et al. 2019. "Physiologically based pharmacokinetic modeling of salivary concentrations for noninvasive biomonitoring of 2,4-dichlorophenoxyacetic acid (2,4-D)." Toxicological Sciences 171, no. 2:330-343. PNNL-SA-143610. doi:10.1093/toxsci/kfz206
  • Hess B.M., D.G. Thomas, T.J. Weber, J.R. Hutchison, T.M. Straub, C.J. Bruckner-Lea, and J.D. Powell, et al. 2019. "An integrated experimental-computational approach for predicting virulence in New Zealand white rabbits and humans following inhalation exposure to Bacillus anthracis spores." PLoS Pathogens 14, no. 7:e0219160. PNNL-SA-140673. doi:10.1371/journal.pone.0219160
  • Smith J.N., J.G. Teeguarden, and T.J. Weber. 2019. Proposed Occupational Exposure Limits for Furans. PNNL-26775 Rev0. Richland, WA: Pacific Northwest National Laboratory. Proposed Occupational Exposure Limits for Furans


  • Carver Z.A., A. Han, C. Timchalk, T.J. Weber, K.J. Tyrrell, R.L. Sontag, and T. Luders, et al. 2018. "Evaluation of Non-invasive Biomonitoring of 2,4-Dichlorophenoxyacetic Acid (2,4-D) in Saliva." Toxicology 410. PNNL-SA-135310. doi:10.1016/j.tox.2018.08.003
  • Smith J.N., J.G. Teeguarden, and T.J. Weber. 2018. Proposed Risk-Based Approach for Nitrosamine Chemicals of Potential Concern. PNNL-26787 Rev. 0. Richland, WA: Pacific Northwest National Laboratory. Proposed Risk-Based Approach for Nitrosamine Chemicals of Potential Concern


  • Smith J.N., Z.A. Carver, T.J. Weber, and C. Timchalk. 2017. "Predicting Transport of 3,5,6-Trichloro-2-pyridinol into Saliva Using a Combination Experimental and Computational Approach." Toxicological Sciences 157, no. 2:438-450. PNNL-SA-123133. doi:10.1093/toxsci/kfx055
  • Timchalk C., T.J. Weber, and J.N. Smith. 2017. "The Need for Non- or Minimally-Invasive Biomonitoring Strategies and the Development of Pharmacokinetic/Pharmacodynamic Models for Quantification." Current Opinion in Toxicology 4. PNNL-SA-124528. doi:10.1016/j.cotox.2017.03.003


  • Tilton S.C., M.M. Matzke, M.B. Sowa, D.L. Stenoien, T.J. Weber, W.F. Morgan, and K.M. Waters. 2015. "Data Integration Reveals Key Homeostatic Mechanisms Following Low Dose Radiation Exposure." Toxicology and Applied Pharmacology 285, no. 2:1-11. PNNL-SA-102570. doi:10.1016/j.taap.2015.01.019
  • Timchalk C., T.J. Weber, and J.N. Smith. 2015. "Computational Strategy for Quantifying Human Pesticide Exposure based upon a Saliva Measurement." Frontiers in Pharmacology 6. PNNL-SA-108384. doi:10.3389/fphar.2015.00115
  • Wright A.T., T. Magnaldo, R.L. Sontag, L.N. Anderson, N.C. Sadler, P.D. Piehowski, and Y. Gache, et al. 2015. "Deficient Expression of Aldehyde Dehydrogenase 1A1 Is Consistent with Increased Sensitivity of Gorlin Syndrome Patients to Radiation Carcinogenesis." Molecular Carcinogenesis 54, no. 6:473-484. PNNL-SA-95210. doi:10.1002/mc.22115


  • Genetos D.C., A. Wong, T.J. Weber, N.J. Karin, and C.E. Yellowley. 2014. "Impaired osteoblast differentiation in Annexin A2- and -A5-deficient cells." PLoS One 9, no. 9:Article No. e107482. PNNL-SA-90399. doi:10.1371/journal.pone.0107482
  • Waters K.M., B.S. Cummings, H. Shankaran, N.E. Scholpa, and T.J. Weber. 2014. "ERK Oscillation-Dependent Gene Expression Patterns and Deregulation by Stress-Response." Chemical Research in Toxicology 27, no. 9:1496-1503. PNNL-SA-101628. doi:10.1021/tx500085u


  • Wang Y., Z. Li, T.J. Weber, D. Hu, C.T. Lin, J. Li, and Y. Lin. 2013. "In Situ Live Cell Sensing of Multiple Nucleotides Exploiting DNA/RNA Aptamers and Graphene Oxide Nanosheets." Analytical Chemistry 85, no. 14:6775-6782. PNNL-SA-96634. doi:10.1021/ac400858g
  • Waters K.M., R.L. Sontag, and T.J. Weber. 2013. "Hepatic Leukemia Factor Promotes Resistance To Cell Death: Implications For Therapeutics and Chronotherapy." Toxicology and Applied Pharmacology 268, no. 2:141-148. PNNL-SA-93319. doi:10.1016/j.taap.2013.01.031


  • Shankaran H., T.J. Weber, C.H. Freiin von Neubeck, and M.B. Sowa. 2012. "Using Imaging Methods to Interrogate Radiation-Induced Cell Signaling." Radiation Research 177, no. 4:496-507. PNNL-SA-79763. doi:10.1667/RR2669.1
  • Sontag R.L., and T.J. Weber. 2012. "Ectopic ERK Expression Induces Phenotypic Conversion of C10 Cells and Alters DNA Methyltransferase Expression." BMC Research Notes 5. PNNL-SA-84800. doi:10.1186/1756-0500-5-217
  • Waters K.M., D.L. Stenoien, M.B. Sowa, C.H. Freiin Von Neubeck, W.B. Chrisler, R. Tan, and R.L. Sontag, et al. 2012. "Annexin A2 Modulates Radiation-Sensitive Transcriptional Programming and Cell Fate." Radiation Research 179, no. 1:56-61. PNNL-SA-84443. doi:10.1667/RR3056.1
  • Waters K.M., T. Liu, R.D. Quesenberry, A.R. Willse, S. Bandyopadhyay, L.E. Kathmann, and T.J. Weber, et al. 2012. "Network Analysis of Epidermal Growth Factor Signaling using Integrated Genomic, Proteomic and Phosphorylation Data." PLoS One 7, no. 3:Article No. e34515. PNNL-SA-85737. doi:10.1371/journal.pone.0034515


  • Zangar R.C., N. Bollinger, T.J. Weber, R. Tan, L.M. Markillie, and N.J. Karin. 2011. "Reactive Oxygen Species Alter Autocrine and Paracrine Signaling." Free Radical Biology & Medicine 51, no. 11:2041-2047. PNNL-SA-84606. doi:10.1016/j.freeradbiomed.2011.09.001


  • Shankaran H., W.B. Chrisler, R.L. Sontag, and T.J. Weber. 2010. "Inhibition of ERK Oscillations by Ionizing Radiation and Reactive Oxygen Species." Molecular Carcinogenesis 50, no. 6:424-432. PNNL-SA-74660. doi:10.1002/mc.20724
  • Weber T.J., H. Shankaran, H.S. Wiley, L.K. Opresko, W.B. Chrisler, and R.D. Quesenberry. 2010. "Basic Fibroblast Growth Factor Regulates Persistent ERK Osciliations in Premaligant but not Malignant JB6 Cells." Journal of Investigative Dermatology 130, no. 5:144-156. PNNL-SA-59833.


  • Waters K.M., R. Tan, L.K. Opresko, R.D. Quesenberry, S. Bandyopadhyay, W.B. Chrisler, and T.J. Weber. 2009. "Cellular Dichotomy Between Anchorage-Independent Growth Responses to bFGF and TA Reflects Molecular Switch in Commitment to Carcinogenesis." Molecular Carcinogenesis 48, no. 11:1059-1069. PNNL-SA-57090.
  • Weber T.J., L.K. Opresko, D.M. Waisman, G.J. Newton, R.D. Quesenberry, N. Bollinger, and R.J. Moore, et al. 2009. "Regulation of the Low Dose Radiation Paracrine-Specific Anchorage-Independent Growth Response by Annexin A2." Radiation Research 172, no. 1:96-105. PNNL-SA-56968. doi:10.1667/RR1220.1


  • Sweeney L.M., K.D. Thrall, T.S. Poet, R. Corley, T.J. Weber, B.J. Locey, and J. Clarkson, et al. 2008. "Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans." Toxicological Sciences 101, no. 1:32-50. PNWD-SA-8061. doi:10.1093/toxsci/kfm251


  • Dutta D., S.K. Sundaram, J.G. Teeguarden, B.J. Riley, L.S. Fifield, J.M. Jacobs, and R.S. Addleman, et al. 2007. "Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials." Toxicological Sciences 100, no. 1:303-315. PNNL-SA-55139. doi:10.1093/toxsci/kfm217


  • Weber T.J., H.S. Smallwood, L.E. Kathmann, L.M. Markillie, T.C. Squier, and B.D. Thrall. 2006. "Functional link between TNF biosynthesis and CaM-dependent activation of inducible nitric oxide synthase in RAW 264.7 macrophages." American Journal of Physiology. Cell Physiology 290, no. 6:C1512-C1520. PNNL-SA-47434. doi:10.1152/ajpcell.00527.2005


  • Weber T.J., R.W. Siegel, L. Markillie, W.B. Chrisler, X.C. Lei, and N.H. Colburn. 2005. "A paracrine signal mediates the cell transformation response to low dose gamma radiation in JB6 cells." Molecular Carcinogenesis 43, no. 1:31-37. PNNL-SA-41438.


  • Weber T.J., S. Negash, H.S. Smallwood, K.S. Ramos, B.D. Thrall, and T.C. Squier. 2004. "Calmodulin Involvement in Stress-Activated Nuclear Localization of Albumin in JB6 Epithelial Cells." Biochemistry 43, no. 23:7443-7450. PNNL-SA-40924.


  • Weber T.J., and L.M. Markillie. 2003. "Regulation of activator protein-1 by 8-iso-prostaglandin E2 in a thromboxane A2 receptor-dependent and -independent manner." Molecular Pharmacology 63, no. 5:1075-1081. PNNL-SA-42109.
  • Weber T.J., and L.M. Markillie. 2003. "Regulation of Activator Protein-1 by 8-iso-Prostaglandin E2 in a Thromboxane A2 Receptor-Dependent and -Independent Manner." Molecular Pharmacology 63, no. 5:1075-81. PNNL-SA-42101.


  • Majors P.D., K.R. Minard, E.J. Ackerman, G.R. Holtom, D.F. Hopkins, C.I. Parkinson, and T.J. Weber, et al. 2002. "A combined confocal and magnetic resonance microscope for biological studies." Review of Scientific Instruments 73, no. 12:4329-4338. PNNL-SA-37808.
  • Weber T.J., L.M. Markillie, W.B. Chrisler, G.A. Vielhauer, and J.W. Regan. 2002. "Modulation of JB6 Mouse Epidermal Cell Transformation Response by the Prostaglandin F2 alpha Receptor." Molecular Carcinogenesis 35, no. 4:163-172. PNNL-SA-38182.
  • Weber T.J., L.M. Markillie, W.B. Chrisler, G.A. Vielhauer, and J.W. Regan. 2002. "Modulation of JB6 Mouse Epidermal Cell Transformation Response by the Prostaglandin F2 Alpha Receptor." Molecular Carcinogenesis 35, no. 4:163-172. PNWD-SA-5669.
  • Wind R.A., P.D. Majors, K.R. Minard, E.J. Ackerman, D.S. Daly, G.R. Holtom, and B.D. Thrall, et al. 2002. "Combined Confocal and Magnetic Resonance Microscopy." Applied Magnetic Resonance 22, no. 2:145-158. PNNL-SA-35466.


  • Weber T.J., Q. Huang, T.J. Monks, and S.S. Lau. 2001. "Differential Regulation of Redox Responsive Transcription Factors by the Nephrocarcinogen 2,3,5-tris(glutathion-S-yl)hydroquinone." Chemical Research in Toxicology 14, no. 7:814-821. PNNL-SA-34080.


  • Towndrow K.M., J.J. Mertens, J.K. Jeong, T.J. Weber, T.J. Monks, and S.S. Lau. 2000. "Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E(2) synthesis in renal epithelial cells." Chemical Research in Toxicology 13, no. 2:111-117. PNWD-SA-5240.
  • Weber T.J., T.J. Monks, and S.S. Lau. 2000. "DDM-PGE(2)-mediated cytoprotection in renal epithelial cells by a thromboxane A(2) receptor coupled to NF-kappaB." American Journal of Physiology. Cell Physiology 278, no. 2:F270-278. PNWD-SA-5237.


  • Weber T.J., T.J. Monks, and S.S. Lau. 1997. "PGE2-mediated cytoprotection in renal epithelial cells: evidence for a pharmacologically distinct receptor." American Journal of Physiology 273, no. 4:F507-F515. PNWD-SA-5258. doi:10.1152/ajprenal.1997.273.4.F507

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