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Fundamental and Computational Sciences Directorate

Staff information

Eric Hill

Microbiome Science
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-18
Richland, WA 99352

PNNL Publications


  • Bohutskyi P., L.A. Kucek, E.A. Hill, G.E. Pinchuk, S.G. Mundree, and A.S. Beliaev. 2018. "Conversion of stranded waste-stream carbon and nutrients into value-added products via metabolically coupled binary heterotroph-photoautotroph system." Bioresource Technology 260. PNNL-SA-126703. doi:10.1016/j.biortech.2018.02.080


  • Bernstein H.C., R.S. McClure, V. Thiel, N.C. Sadler, Y. Kim, W.B. Chrisler, and E.A. Hill, et al. 2017. "Indirect interspecies regulation; transcriptional and physiological responses of a cyanobacterium to heterotrophic partnership." mSystems 2, no. 2:Article No. e00181-16. PNNL-SA-113682. doi:10.1128/mSystems.00181-16
  • Hill E.A., W.B. Chrisler, A.S. Beliaev, and H.C. Bernstein. 2017. "A flexible microbial co-culture platform for simultaneous utilization of methane and carbon dioxide from gas feedstocks." Bioresource Technology 228. PNNL-SA-122746. doi:10.1016/j.biortech.2016.12.111
  • Komorek R.E., W. Wei, X. Yu, E.A. Hill, J. Yao, Z. Zhu, and X. Yu. 2017. "In Situ Characterization of Shewanella oneidensis MR1 Biofilms by SALVI and ToF-SIMS." Journal of Visualized Experiments. PNNL-SA-123316. doi:10.3791/55944


  • Bernstein H.C., R.S. McClure, E.A. Hill, L.M. Markillie, W.B. Chrisler, M.F. Romine, and J.E. McDermott, et al. 2016. "Unlocking the Constraints of Cyanobacterial Productivity: Acclimations Enabling Ultrafast Growth." mBio 7, no. 4:Article No. e00949-16. PNNL-SA-112394. doi:10.1128/mBio.00949-16
  • McClure R.S., C.C. Overall, J.E. McDermott, E.A. Hill, L.M. Markillie, L.A. McCue, and R.C. Taylor, et al. 2016. "Network Analysis of Transcriptomics Expands Regulatory Landscapes in Synechococcus sp. PCC 7002." Nucleic Acids Research 44, no. 18:8810-8825. PNNL-SA-113421. doi:10.1093/nar/gkw737
  • Sadler N.C., H.C. Bernstein, M.R. Melnicki, M.A. Charania, E.A. Hill, L.N. Anderson, and M.E. Monroe, et al. 2016. "Dinitrogenase Driven Photobiological Hydrogen Production Combats Oxidative Stress in Cyanothece sp. ATCC 51142." Applied Environmental Microbiology 82, no. 24:7227-7235. PNNL-SA-113160. doi:10.1128/AEM.02098-16


  • Bernstein H.C., M.A. Charania, R.S. McClure, N.C. Sadler, M.R. Melnicki, E.A. Hill, and L.M. Markillie, et al. 2015. "Multi-omic Dynamics Associate Oxygenic Photosynthesis with Nitrogenase-mediated H2 production in Cyanothece sp. ATCC 51142." Scientific Reports 5. PNNL-SA-111925. doi:10.1038/srep16004
  • Song H., R.S. McClure, H.C. Bernstein, C.C. Overall, E.A. Hill, and A.S. Beliaev. 2015. "Integrated in silico analyses of regulatory and metabolic networks of Synechococcus sp. PCC 7002 reveal relationships between gene centrality and essentiality." Life 5, no. 2:1127-1140. PNNL-SA-109173. doi:10.3390/life5021127


  • Ansong C., N.C. Sadler, E.A. Hill, M.P. Lewis, E.M. Zink, R.D. Smith, and A.S. Beliaev, et al. 2014. "Characterization of protein redox dynamics induced during light-to-dark transitions and nutrient limitation in cyanobacteria." Frontiers in Microbiology 5. PNNL-SA-101966. doi:10.3389/fmicb.2014.00325
  • Beliaev A.S., M.F. Romine, M. Serres, H.C. Bernstein, B.E. Linggi, L.M. Markillie, and N.G. Isern, et al. 2014. "Inference of Interactions in Cyanobacterial-Heterotrophic Co-Cultures via Transcriptome Sequencing." The ISME Journal 8, no. 11:2243-2255. PNNL-SA-98626. doi:10.1038/ismej.2014.69
  • Bernstein H.C., A. Konopka, M.R. Melnicki, E.A. Hill, L.A. Kucek, S. Zhang, and G. Shen, et al. 2014. "Effect of mono- and dichromatic light quality on growth rates and photosynthetic performance of Synechococcus sp. PCC 7002." Frontiers in Microbiology 5. PNNL-SA-101364. doi:10.3389/fmicb.2014.00488
  • Hua X., X. Yu, Z. Wang, L. Yang, B. Liu, Z. Zhu, and A.E. Tucker, et al. 2014. "In situ molecular imaging of hydrated biofilm in a microfluidic reactor by ToF-SIMS." Analyst 139. PNNL-SA-99617. doi:10.1039/C3AN02262E
  • Kreuzer H.W., E.A. Hill, J.J. Moran, R.A. Bartholomew, Y. Hui, and E.L. Hegg. 2014. "Contributions of the [NiFe]- and [FeFe]-hydrogenase to H2 production in Shewanella oneidensis MR-1 as revealed by isotope ratio analysis of evolved H2." FEMS Microbiology Letters 352, no. 1:18-24. PNNL-SA-98025. doi:10.1111/1574-6968.12361
  • Sadler N.C., M.R. Melnicki, M.H. Serres, E.D. Merkley, W.B. Chrisler, E.A. Hill, and M.F. Romine, et al. 2014. "Live Cell Chemical Profiling of Temporal Redox Dynamics in a Photoautotrophic Cyanobacterium." ACS Chemical Biology 9, no. 1:291-300. PNNL-SA-93812. doi:10.1021/cb400769v


  • Melnicki M.R., G.E. Pinchuk, E.A. Hill, L.A. Kucek, S. Stolyar, J.K. Fredrickson, and A. Konopka, et al. 2013. "Feedback-Controlled LED Photobioreactor for Photophysiological Studies of Cyanobacteria." Bioresource Technology 134. PNNL-SA-91362. doi:10.1016/j.biortech.2013.01.079
  • Taylor R.C., B.M. Webb-Robertson, L.M. Markillie, M.H. Serres, B.E. Linggi, J.T. Aldrich, and E.A. Hill, et al. 2013. "Changes in Translational Efficiency is a Dominant Regulatory Mechanism in the Environmental Response of Bacteria." Integrative Biology 5, no. 11:1393-1406. PNNL-SA-95628. doi:10.1039/C3IB40120K
  • Vu T., E.A. Hill, L.A. Kucek, A. Konopka, A.S. Beliaev, and J.L. Reed. 2013. "Computational evaluation of Synechococcus sp. PCC 7002 metabolism for chemical production." Biotechnology Journal 8, no. 5:619-630. PNNL-SA-95015. doi:10.1002/biot.201200315


  • Melnicki M.R., G.E. Pinchuk, E.A. Hill, L.A. Kucek, J.K. Fredrickson, A. Konopka, and A.S. Beliaev. 2012. "Sustained H2 Production Driven by Photosynthetic Water Splitting in a Unicellular Cyanobacterium." mBio 3, no. 4:Article No. e00197-12. PNNL-SA-85855. doi:10.1128/mBio.00197-12
  • Vu T., S. Stolyar, G.E. Pinchuk, E.A. Hill, L.A. Kucek, R.N. Brown, and M.S. Lipton, et al. 2012. "Genome-Scale Modeling of Light-Driven Reductant Partitioning and Carbon Fluxes in Diazotrophic Unicellular Cyanobacterium Cyanothece sp. ATCC 51142." PLoS Computational Biology 8, no. 4:E1002460. PNNL-SA-83135. doi:10.1371/journal.pcbi.1002460
  • Vu T., S. Stolyar, G.E. Pinchuk, E.A. Hill, L.A. Kucek, R.N. Brown, and M.S. Lipton, et al. 2012. "Genome-scale modeling of light-driven reductant partitioning and carbon fluxes in diazotrophic unicellular cyanobacterium Cyanothece sp. ATCC 51142." PLoS Computational Biology 8, no. 4:e1002460. PNNL-SA-83348. doi:10.1371/journal.pcbi.1002460


  • McDermott J.E., C.S. Oehmen, L.A. McCue, E.A. Hill, D.M. Choi, J. Stockel, and M.L. Liberton, et al. 2011. "A Model of Cyclic Transcriptomic Behavior in Cyanobacterium Cyanothece sp. ATCC 51142." Molecular Biosystems 7, no. 8:2407-2418. PNNL-SA-74409. doi:10.1039/C1MB05006K
  • Pinchuk G.E., O.V. Geydebrekht, E.A. Hill, J.L. Reed, A. Konopka, A.S. Beliaev, and J.K. Fredrickson. 2011. "Pyruvate and Lactate Metabolism by Shewanella oneidensis MR-1 under Fermentation, Oxygen Limitation, and Fumarate Respiration Conditions." Applied and Environmental Microbiology 77, no. 23:8234-8240. PNNL-SA-79834. doi:10.1128/AEM.05382-11
  • Pinchuk G.E., O.V. Geydebrekht, E.A. Hill, J.L. Reed, A. Konopka, A.S. Beliaev, and J.K. Fredrickson. 2011. "Pyruvate and Lactate Metabolism by Shewanella oneidensis MR-1 under Fermentation, Oxygen Limitation, and Fumarate Respiration Conditions." Applied and Environmental Microbiology 77, no. 23:8234-8240. PNNL-SA-83134. doi:10.1128/AEM.05382-11


  • Pinchuk G.E., E.A. Hill, O.V. Geydebrekht, J. De Ingeniis, X. Zhang, A. Osterman, and J.H. Scott, et al. 2010. "Constraint-Based Model of Shewanella oneidensis MR-1 Metabolism: a Tool for Data Analysis and Hypothesis Generation." PLoS Computational Biology 6, no. 6:Art. No. e1000822. PNNL-SA-68769. doi:10.1371/journal.pcbi.1000822


  • Elias D.A., S.L. Tollaksen, D.W. Kennedy, H.M. Mottaz, C.S. Giometti, J.S. Mclean, and E.A. Hill, et al. 2008. "The Influence of Cultivation Methods on Shewanella oneidensis Physiology and Proteome Expression." Archives of Microbiology 189, no. 4:313-324. PNNL-SA-57471. doi:10.1007/s00203-007-0321-y
  • Mclean J.S., G.E. Pinchuk, O.V. Geydebrekht, C.L. Bilskis, B.A. Zakrajsek, E.A. Hill, and D. Saffarini, et al. 2008. "Oxygen-dependent autoaggregation in Shewanella oneidensis MR-1." Environmental Microbiology 10, no. 7:1861-1876. PNNL-SA-47123. doi:10.1111/j.1462-2920.2008.01608.x
  • Shi L., S. Deng, M.J. Marshall, Z. Wang, D.W. Kennedy, A. Dohnalkova, and H.M. Mottaz, et al. 2008. "Direct Involvement of Type II Secretion System in Extracellular Translocation of Shewanella Oneidensis Outer Membrane Cytochromes MtrC and OmcA." Journal of Bacteriology 190, no. 15:5512-5516. PNNL-SA-55117. doi:10.1128/JB.00514-08


  • Ntarlagiannis D.E., E.A. Atekwana, E.A. Atekwana, E.A. Hill, and Y.A. Gorby. 2007. "Microbial Nanowires: Is the subsurface "hardwired?"." Geophysical Research Letters 34, no. 17:Art. No. L17305. PNNL-SA-57091. doi:10.1029/2007GL030426


  • Gorby Y.A., S. Yanina, J.S. Mclean, K.M. Rosso, D.M. Moyles, A. Dohnalkova, and T.J. Beveridge, et al. 2006. "Electrically Conductive Bacterial Nanowires Produced by Shewanella Oneidensis Strain MR-1 and Other Microorganisms." Proceedings of the National Academy of Sciences of the United States of America 103, no. 30:11358-11363. PNNL-SA-45840.
  • Shi L., B. Chen, Z. Wang, D.A. Elias, M.U. Mayer, Y.A. Gorby, and S. Ni, et al. 2006. "Isolation of a High-Affinity Functional Protein Complex between OmcA and MtrC: Two Outer Membrane Decaheme c-type Cytochromes of Shewanella oneidensis MR-1." Journal of Bacteriology 188, no. 13:4705-4714. PNNL-SA-45401. doi:10.1128/JB.01966-05


  • Markillie L.M., C.T. Lin, J.N. Adkins, D.L. Auberry, E.A. Hill, B.S. Hooker, and P.A. Moore, et al. 2005. "Simple Protein Complex Purification and Identification Method Suitable for High- throughput Mapping of Protein Interaction Networks." Journal of Proteome Research 4, no. 2:268-274. PNNL-SA-42494. doi:10.1021/pr049847a
  • Wunschel D.S., E.A. Hill, J.S. Mclean, K.H. Jarman, Y.A. Gorby, N.B. Valentine, and K.L. Wahl. 2005. "Effects of Varied pH, Growth Rate and Temperature using Controlled fermentation and Batch culture on Matrix Assisted Laser Desorption/Ionization Whole Cell Protein Fingerprints." Journal of Microbiological Methods 62, no. 3:259-271. PNNL-SA-45204.

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