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Fundamental and Computational Sciences Directorate

Staff information

Sara Gosline

Computational Biology
Data Scientist

PNNL Publications

2024

  • Feng S., A. Calinawan, P. Pugliese, P. Wang, M. Ceccarelli, F. Petralia, and S. Gosline. 2024. "Decomprolute is a benchmarking platform designed for multiomics-based tumor deconvolution." Cell Reports Methods 4, no. 2:Art. No. 100708. PNNL-SA-180136. doi:10.1016/j.crmeth.2024.100708
  • Joshi S.K., P.D. Piehowski, T. Liu, S. Gosline, J.E. McDermott, B. Druker, and E. Traer, et al. 2024. "Mass spectrometry-based proteogenomics: New therapeutic opportunities for precision medicine." Annual Review of Pharmacology and Toxicology 64. PNNL-SA-182628. doi:10.1146/annurev-pharmtox-022723-113921
  • Lin H., M. Mohammadhosseini, J. McClatchy, M. Villamor-Paya, S. Jeng, D. Bottomly, and C. Tsai, et al. 2024. "The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1B-mediated AML progression." Blood 143, no. 26:2749-2762. PNNL-SA-185293. doi:10.1182/blood.2023022079
  • Modak R.V., K. Rebola, J. Mcclatchy, M. Mohammadhosseini, A. Damnernsawad, S.E. Kurtz, and C.A. Eide, et al. 2024. "Targeting CCL2/CCR2 signaling overcomes MEK inhibitor resistance in Acute Myeloid Leukemia." Clinical Cancer Research 30, no. 10:2245 - 2259. PNNL-SA-187155. doi:10.1158/1078-0432.CCR-23-2654
  • Nguyen H., E. Kohl, J.L. Bade, S.E. Eng, A. Tosevska, A. Al Shihabi, and P.J. Tebon, et al. 2024. "A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening." Cell Reports Methods 4, no. 5:Art. No. 100772. PNNL-ACT-SA-10702. doi:10.1016/j.crmeth.2024.100772
  • Petralia F., W. Ma, T.M. Yaron, F. Pia Caruso, N. Tignor, J. Wang, and D. Charytonowicz, et al. 2024. "Pan-cancer Proteogenomics Characterization of Tumor Immunity." Cell 187, no. 5:1255-1277.e27. PNNL-SA-188762. doi:10.1016/j.cell.2024.01.027
  • Pino J.C., J.C. Posso Escobar, S.K. Joshi, M.D. Nestor, J. Moon, J.R. Hansen, and C.M. Hutchinson, et al. 2024. "Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia." Cell Reports Medicine 5, no. 1:Art. No. 101359. PNNL-SA-185276. doi:10.1016/j.xcrm.2023.101359
  • Zitnik M., M. Li, A. Wells, K. Glass, D. Gysi, A. Krishnan, and T. Murali, et al. 2024. "Current and future directions in network biology." Bioinformatics Advances 4, no. 1:Art. No. vbae099. PNNL-SA-190412. doi:10.1093/bioadv/vbae099

2023

  • Gosline S., D. Kim, P. Pande, D.G. Thomas, L. Truong, P. Hoffman, and M. Barton, et al. 2023. "The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes." Scientific Data 10. PNNL-SA-177557. doi:10.1038/s41597-023-02021-5
  • Gosline S., M. Velickovic, J.C. Pino, L.Z. Day, I.K. Attah, A.C. Swensen, and V.G. Danna, et al. 2023. "Proteome mapping of the human pancreatic islet microenvironment reveals endocrine-exocrine signaling sphere of influence." Molecular & Cellular Proteomics 22, no. 8:Art. No. 100592. PNNL-SA-179489. doi:10.1016/j.mcpro.2023.100592
  • Larsson A., H. Bhatia, A. Calizo, K. Pollard, X. Zhang, E. Conniff, and J. Tibbitts, et al. 2023. "Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology." Neuro-Oncology 25, no. 11:2044-2057. PNNL-ACT-SA-10646. doi:10.1093/neuonc/noad097
  • Wang J., A. Calizo, L. Zhang, J.C. Pino, Y. Lyu, K. Pollard, and X. Zhang, et al. 2023. "CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors." Science Advances 9, no. 47:Art. No. eadg8876. PNNL-SA-181806. doi:10.1126/sciadv.adg8876

2022

  • Gosline S., C.E. Tognon, M.D. Nestor, S.K. Joshi, R.V. Modak, A. Damnernsawad, and J.C. Posso Escobar, et al. 2022. "Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML." Clinical Proteomics 19. PNNL-SA-163043. doi:10.1186/s12014-022-09367-9

2021

  • Danna V.G., H.D. Mitchell, L.N. Anderson, I.G. Godinez, S. Gosline, J.G. Teeguarden, and J.E. McDermott. 2021. "leapR: An R Package for MultiOmic Pathway Analysis." Journal of Proteome Research 20, no. 4:2116-2121. PNNL-SA-159351. doi:10.1021/acs.jproteome.0c00963
  • Dehner C., C.I. Moon, X. Zhang, Z. Zhou, C.A. Miller, H. Xu, and X. Wan, et al. 2021. "Chromosome 8 gain is associated with high-grade transformation in MPNST." JCI Insight 6, no. 6:e146351. PNNL-ACT-SA-10528. doi:10.1172/jci.insight.146351
  • Joshi S.K., T. Nechiporuk, D. Bottomly, P.D. Piehowski, J. Reisz, J. Pittsenbarger, and A. Kaempf, et al. 2021. "The AML microenvironment catalyzes a step-wise evolution to gilteritinib resistance." Cancer Cell 39, no. 7:999-1014. PNNL-SA-161620. doi:10.1016/j.ccell.2021.06.003
  • Way G.P., C.S. Greene, P. Carninci, B.S. Carvalho, M. Hoon, S. Finley, and S. Gosline, et al. 2021. "A field guide to cultivating computational biology." PLoS Biology 19, no. 10:Article No. e3001419. PNNL-SA-166678. doi:10.1371/journal.pbio.3001419

2020

  • Pollard K., J. Banerjee, X. Doan, J. Wang, X. Guo, R. Allaway, and S. Langmead, et al. 2020. "A clinically and genomically annotated nerve sheath tumor biospecimen repository." Scientific Data 7. PNNL-SA-152474. doi:10.1038/s41597-020-0508-5

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