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Fundamental and Computational Sciences Directorate

Staff information


Karin Rodland

Biological Sciences Division
Laboratory Fellow
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352


Dr. Rodland's research involves the use of cutting edge mass spectrometry technologies and innovative computational biology analysis methods to further understanding of compelling problems in both basic and translational biomedical research. A key element in this approach is the integration of multiple different data types in order to map the flow of information within cells from genotype to phenotype, and to develop predictive models of responses to perturbation, including growth factors, cytokines, and therapeutic interventions. Dr. Rodland is also committed to the development of alternative approaches for biomarker discovery that incorporate both rigorous computational and statistical considerations with the deep insight of cancer biologists who understand the complexities of interacting signaling networks. This approach focuses on understanding the signaling pathways that are dysregulated in disease, as opposed to simple differential expression of individual genes or gene products. Dr. Rodland was among the first to characterize the role of the G-protein coupled calcium-sensing receptor in modulating proliferation-associated signal transduction pathways. Dr. Rodland also holds a joint appointment as Affiliate Professor of Cell, Developmental, and Cancer Biology at Oregon Health & Science University, and is a Fellow of the American Association for the Advancement of Science.

Research Interests

  • Understanding mechanisms of signal transduction in normal cells and how these mechanisms are altered in cancer cells
  • Applying a systems biology approach to understand how distinct signalling pathways are integrated to fine tune cellular responses
  • Applying proteomics capabilities developed at PNNL to identify biomarkers for early detection of breast and other cancers, and in developing new biomarker assays

Education and Credentials

  • Ph.D., Biology, Syracuse University
  • A.B., Biology/Education, Hood College

Affiliations and Professional Service

Science at PNNL

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