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Karin Rodland

Karin Rodland

Biological Sciences Division
Laboratory Fellow, TL
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352
509/371-6935

Biography

Dr. Rodland's research is focused on mechanisms of signal transduction in normal cells and how these mechanisms are altered in cancer cells. She is particularly interested in using a systems biology approach to understand how distinct signalling pathways are integrated to fine tune cellular responses. She is involved in efforts to apply a proteomics based approach to identify biomarkers for early diagnosis of cancer and other chronic diseases, and in the use of systems biology to identify potential therapeutic targets. Dr. Rodland was the among the first to demonstrate that variations in extracellular calcium concentration could be sensed by a variety of epithelial and mesenchymal cells through activation of the G-protein coupled calcium-sensing receptor, resulting in activation of the Ras-Raf-MEK-ERK signaling cascade. Dr. Rodland's current research focuses on understanding the cross-talk between multiple signaling pathways acting through the EGF receptor axis.

Prior to joining the Pacific Northwest National Laboratory, Dr. Rodland was an associate professor in the department of cell and developmental biology at Oregon Health Sciences University from 1985-2001. Dr. Rodland retains her status as member of the Oregon Cancer Institute and as a collaborating scientist at the Oregon Regional Primate Research Center.

Research Interests

  • Understanding mechanisms of signal transduction in normal cells and how these mechanisms are altered in cancer cells
  • Applying a systems biology approach to understand how distinct signalling pathways are integrated to fine tune cellular responses
  • Applying proteomics capabilities developed at PNNL to identify biomarkers for early detection of breast and other cancers, and in developing new biomarker assays

Education and Credentials

  • Ph.D., Biology, Syracuse University
  • A.B., Biology/Education, Hood College

Affiliations and Professional Service

  • Board of Directors Member, U.S Human Proteome Organisation
  • American Society for Cell Biology
  • American Society for Biochemistry and Molecular Biology
  • American Association for Cancer Research
  • American Association for the Advancement of Science
  • Editor of Cancer Biomarkers and Cancer Genomics and Proteomics

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