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Staff information

Gregory Piepel

Stat Modlng & Expr Design
Lab Fellow, Statistician
Pacific Northwest National Laboratory
PO Box 999
MSIN: K7-20
Richland, WA 99352

PNNL Publications

2018

  • Hutchison J.R., G.F. Piepel, B.G. Amidan, B.M. Hess, M.A. Sydor, and B. Kaiser. 2018. "Comparison of false-negative rates and limits of detection following macrofoam-swab sampling of Bacillus anthracis surrogates via Rapid Viability PCR and plate culture." Journal of Applied Microbiology 124, no. 5:1092-1106. PNNL-SA-118902. doi:10.1111/jam.13706
  • Pattarino F., G.F. Piepel, and M. Rinaldi. 2018. "Improvement of a Mixture Experiment Model Relating the Component Proportions to the Size of Nanonized Itraconazole Particles in Extemporary Suspensions." European Journal of Pharmaceutical Sciences 117. PNNL-SA-123916. doi:10.1016/j.ejps.2018.03.005

2016

  • Hutchison J.R., G.F. Piepel, B.G. Amidan, M.A. Sydor, and B. Kaiser. 2016. False Negative Rates of a Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates via Real-Time PCR. PNNL-24204 Rev. 1. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F. 2016. "In Memoriam: John A. Cornell (1941-2016)." Journal of Quality Technology 48, no. 4:301-302. PNNL-SA-120600.
  • Piepel G.F., B. Kaiser, B.G. Amidan, M.A. Sydor, C.A. Barrett, and J.R. Hutchison. 2016. "False-negative rate, limit of detection and recovery efficiency performance of a validated macrofoam-swab sampling method for low surface concentrations of Bacillus anthracis Sterne and Bacillus atrophaeus spores." Journal of Applied Microbiology 121, no. 1:149-162. PNNL-SA-107304. doi:10.1111/jam.13128
  • Piepel G.F., J.R. Hutchison, B. Kaiser, B.G. Amidan, M.A. Sydor, and C.A. Barrett. 2016. Recovery Efficiency, False Negative Rate, and Limit of Detection Performance of a Validated Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates. PNNL-23955 Rev. 1. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., S.K. Cooley, J.D. Vienna, and J.V. Crum. 2016. "Designing a Mixture Experiment When the Components are Subject to a Nonlinear Multiple-Component Constraint." Quality Engineering 28, no. 2:220-230. PNNL-SA-107355. doi:10.1080/08982112.2015.1086003

2015

  • Bamberger J.A., G.F. Piepel, C.W. Enderlin, B.G. Amidan, and A. Heredia-Langner. 2015. "Experimental and Measurement Uncertainty Associated with Characterizing Slurry Mixing Performance of Pulsating Jets at Multiple Scales." In ASME-JSME-KSME Joint Fluids Engineering Conference, Symposium on Uncertainty Quantification in Flow Measurements and Simulations, July 26-31, 2015, Seoul, Korea, 1, V001T27A002. New York, New York:American Society of Mechanical Engineers. PNNL-SA-109501. doi:10.1115/AJKFluids2015-27575
  • Hutchison J.R., G.F. Piepel, B.G. Amidan, M.A. Sydor, and B. Deatherage Kaiser. 2015. False Negative Rates of a Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates via Real-Time PCR. PNNL-24204 Rev0. Richland, WA: Pacific Northwest National Laboratory.
  • Peeler D.K., D. Kim, J.D. Vienna, M.J. Schweiger, and G.F. Piepel. 2015. Office of River Protection Advanced Low-Activity Waste Glass Research and Development Plan. PNNL-24883; EWG-RPT-008. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., J.R. Hutchison, B. Deatherage Kaiser, B.G. Amidan, M.A. Sydor, and C.A. Barrett. 2015. Recovery Efficiency, False Negative Rate, and Limit of Detection Performance of a Validated Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates. PNNL-23955. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., S.K. Cooley, J.D. Vienna, and J.V. Crum. 2015. Experimental Design for Hanford Low-Activity Waste Glasses with High Waste Loading. PNNL-24391; EWG-RPT-006, Rev. 0. Richland, WA: Pacific Northwest National Laboratory.

2014

  • Piepel G.F., A.E. Holmes, A. Heredia-Langner, K.P. Lee, and S.E. Kelly. 2014. Scaling Relationships Based on Scaled Tank Mixing and Transfer Test Results. PNNL-22644 Rev. 1. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., and J.R. Hutchison. 2014. Experimental Design for a Macrofoam Swab Study Relating the Recovery Efficiency and False Negative Rate to Low Concentrations of Two Bacillus anthracis Surrogates on Four Surface Materials. PNNL-23094. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., and J.R. Hutchison. 2014. Experimental Design for a Macrofoam-Swab Study Relating the Recovery Efficiency and False Negative Rate to Low Concentrations of Two Bacillus anthracis Surrogates on Four Surface Materials. PNNL-23094 Rev. 1. Richland, WA: Pacific Northwest National Laboratory.
  • Vienna J.D., D. Kim, I.S. Muller, G.F. Piepel, and A.A. Kruger. 2014. "Toward Understanding the Effect of Low-Activity Waste Glass Composition on Sulfur Solubility." Journal of the American Ceramic Society 97, no. 10:3135-3142. PNNL-SA-100212. doi:10.1111/jace.13125

2013

  • Kaya Y., G.F. Piepel, and E. Caniyilmaz. 2013. "Development of a Rubber-Based Product Using a Mixture Experiment: A Challenging Case Study." Progress in Rubber, Plastics, and Recycling Technology 29, no. 3:123-149. PNNL-SA-85221.
  • Piepel G.F. 2013. "Comment: Spurious Correlation and Other Observations on Experimental Design for Engineering Dimensional Analysis." Technometrics 55, no. 3:286-289. PNNL-SA-93125. doi:10.1080/00401706.2013.778792
  • Piepel G.F., A.E. Holmes, and A. Heredia-Langner. 2013. Scaling Relationships Based on Scaled Tank Mixing and Transfer Test Results. PNNL-22644. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., B.D. Matzke, L.H. Sego, and B.G. Amidan. 2013. Calculating Confidence, Uncertainty, and Numbers of Samples When Using Statistical Sampling Approaches to Characterize and Clear Contaminated Areas. PNNL-22395. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., C. Ozler, and A. Sehirlioglu. 2013. "Optimum Tolerance Design Using Component-Amount and Mixture-Amount Experiments." International Journal of Advanced Manufacturing Technology 68, no. 9-12:2359-2369. PNNL-SA-82766. doi:10.1007/s00170-013-4844-x
  • Westsik J.H., G.F. Piepel, M.J. Lindberg, P.G. Heasler, T.M. Mercier, R.L. Russell, and A. Cozzi, et al. 2013. Supplemental Immobilization of Hanford Low-Activity Waste: Cast Stone Screening Tests. PNNL-22747; SRNL-STI-2013-00465. Richland, WA: Pacific Northwest National Laboratory.

2012

  • Krauter P., G.F. Piepel, R. Boucher, M.S. Tezak, B.G. Amidan, and W. Einfeld. 2012. "False-Negative Rate and Recovery Efficiency Performance of a Validated Sponge Wipe Sampling Method." Applied and Environmental Microbiology 78, no. 3:846-854. PNNL-SA-86204. doi:10.1128/AEM.07403-11
  • Meyer P.A., J.A. Bamberger, C.W. Enderlin, J.A. Fort, B.E. Wells, S.K. Sundaram, and P.A. Scott, et al. 2012. Pulse Jet Mixing Tests With Noncohesive Solids. PNNL-18098 Rev. 1. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., B. Pasquini, S.K. Cooley, A. Heredia-Langner, S. Orlandini, and S. Furlanetto. 2012. "Mixture-process variable approach to optimize a microemulsion electrokinetic chromatography method for the quality control of a nutraceutical based on coenzyme Q10." Talanta 97. PNNL-SA-84864.
  • Piepel G.F., B.G. Amidan, and R. Hu. 2012. "Laboratory studies on surface sampling of Bacillus anthracis contamination: summary, gaps, and recommendations." Journal of Applied Microbiology 113, no. 6:1287-1564. PNNL-SA-84554. doi:10.1111/j.1365-2672.2012.05381.x
  • Piepel G.F., S.K. Cooley, W.L. Kuhn, D.R. Rector, and A. Heredia-Langner. 2012. Methods for Quantifying the Uncertainties of LSIT Test Parameters, Test Results, and Full-Scale Mixing Performance Using Models Developed from Scaled Test Data. PNNL-22033; WPT-RPT-226, Rev0. Richland, WA: Pacific Northwest National Laboratory.
  • Snee R.D., and G.F. Piepel. 2012. "Assessing Component Effects in Formulation Systems." Quality Engineering 25, no. 1:46-53. PNNL-SA-90643. doi:10.1080/08982112.2012.731628

2011

  • Furlanetto S., M. Cirri, G.F. Piepel, N. Mennini, and P. Mura. 2011. "Mixture experiment methods in the development and optimization of microemulsion formulations." Journal of Pharmaceutical and Biomedical Analysis 55, no. 4:610-617. PNNL-SA-76828. doi:10.1016/j.jpba.2011.01.008
  • Glissmeyer J.A., J.E. Flaherty, and G.F. Piepel. 2011. Assessment of the Group 5-6 (LB C2, LB S2, LV S1) Stack Sampling Probe Locations for Compliance with ANSI/HPS N13.1 1999. PNNL-20154. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., B.G. Amidan, and R. Hu. 2011. Laboratory Studies on Surface Sampling of Bacillus anthracis Contamination: Summary, Gaps, and Recommendations. PNNL-20910. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., B.G. Amidan, P. Krauter, and W. Einfeld. 2011. Experimental Design for a Sponge-Wipe Study to Relate the Recovery Efficiency and False Negative Rate to the Concentration of a Bacillus anthracis Surrogate for Six Surface Materials. PNNL-20060 Rev. 1. Richland, WA: Pacific Northwest National Laboratory.

2010

  • Amidan B.G., G.F. Piepel, A. Heredia-Langner, P.A. Meyer, B.E. Wells, J.A. Fort, and J.A. Bamberger, et al. 2010. "A STATISTICAL INTELLIGENCE (STI) APPROACH TO DISCOVERING SPURIOUS CORRELATION IN A PHYSICAL MODEL AND RESOLVING THE PROBLEM WITH AN EXAMPLE OF DESIGNING A PULSE JET MIXING SYSTEM AT HANFORD." In ASME 2010 Pressure Vessels and Piping Division/K-PVP Conference, July 18-22, 2010, Bellevue, Washington, 6, 1167-1178, Paper No. PVP2010-25817. New York, New York:ASME. PNNL-SA-72274. doi:10.1115/PVP2010-25817
  • Piepel G.F. 2010. "Perspectives on Prediction Variance and Bias in Developing, Assessing, and Comparing Experimental Designs." ASQ Statistics Division Newsletter 28, no. 1:16-25. PNNL-SA-69664.
  • Piepel G.F., B.G. Amidan, and J.B. Morrow. 2010. Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies. PNNL-SA-69338 Rev. 1. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., B.G. Amidan, P. Krauter, and W. Einfeld. 2010. Experimental Design for a Sponge-Wipe Study to Relate the Recovery Efficiency and False Negative Rate to the Concentration of a Bacillus anthracis Surrogate for Six Surface Materials. PNNL-20060. Richland, WA: Pacific Northwest National Laboratory.

2009

  • Borkowski J.J., and G.F. Piepel. 2009. "Uniform Designs for Highly Constrained Mixture Experiments." Journal of Quality Technology 41, no. 1:35-47. PNWD-SA-7311.
  • Meyer P.A., J.A. Bamberger, C.W. Enderlin, J.A. Fort, B.E. Wells, S.K. Sundaram, and P.A. Scott, et al. 2009. Pulse Jet Mixing Tests With Noncohesive Solids. PNNL-18098. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F. 2009. "Discussion of “Response Surface Design Evaluation and Comparison” by C.M. Anderson-Cook, C.M. Borror, and D.C Montgomery." Journal of Statistical Planning and Inference 139, no. 2:653-656. PNNL-SA-57282. doi:10.1016/j.jspi.2008.04.008
  • Piepel G.F., and S.K. Cooley. 2009. "Automated Method for Reducing Scheffé Linear Mixture Experiment Models." Quality Technology and Quantitative Management 6, no. 3:255-270. PNWD-SA-7469.
  • Piepel G.F., and S.M. Landmesser. 2009. "Mixture Experiment Alternatives to the Slack Variable Approach." Quality Engineering 21, no. 3:262-276. PNNL-SA-61237. doi:10.1080/08982110902862095
  • Piepel G.F., B.G. Amidan, and B.D. Matzke. 2009. Experimental and Sampling Design for the INL-2 Sample Collection Operational Test. PNNL-18187. Richland, WA: Pacific Northwest National Laboratory.
  • Sahni N.S., G.F. Piepel, and T. Naes. 2009. "Product and Process Improvement Using Mixture-Process Variable Designs and Robust Optimization Techniques." Journal of Quality Technology 41, no. 2:181-197. PNNL-SA-53166.

2008

  • Landmesser S., and G.F. Piepel. 2008. "Comparison of Slack Variable and Mixture Experiment Approaches." In Proceedings of the American Statistical Association, Statistical Computing Section, Joint Statistical Meetings [CD-ROM], 1711-1717. Alexandria, Virginia:American Statistical Association. PNNL-SA-57495.
  • Piepel G.F., A. Heredia-Langner, and S.K. Cooley. 2008. "Property-Composition-Temperature Modeling of Waste Glass Melt Data Subject to a Randomization Restriction." Journal of the American Ceramic Society 91, no. 10:3222-3228. PNNL-SA-58808. doi:10.1111/j.1551-2916.2008.02590.x
  • Piepel G.F., B.G. Amidan, and B.D. Matzke. 2008. "Environmental Sampling Procedures and Methods to Respond to Biological Contamination (White Powder)." In Office of Standards 2007/2008 Annual Report: Programs and Accomplishments. 41-42. Washington, Dc:Department of Homeland Security, Science and Technology Directorate. PNNL-SA-61992.
  • Piepel G.F., S.K. Cooley, and M.R. Paul. 2008. "Upper Tolerance Intervals Adjusted for Multiple Nuisance Uncertainties." Journal of Quality Technology 40, no. 3:245-258. PNWD-SA-7302.

2007

  • Amidan B.G., G.F. Piepel, B.D. Matzke, J.J. Filliben, and B. Jones. 2007. Experimental Design for the INL Sample Collection Operational Test. PNNL-17129. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F. 2007. "A Component Slope Linear Model for Mixture Experiments." Quality Technology and Quantitative Management 4, no. 3:331-343. PNWD-SA-6313.
  • Piepel G.F. 2007. "Mixture Experiments." In Encyclopedia of Statistics in Quality and Reliability, edited by F Ruggeri, R Kenett, and FW Faltin. 1099-1112. Chichester:John Wiley & Sons Ltd. PNNL-SA-51985.

2006

  • Piepel G.F. 2006. "50 Years of Mixture Experiment Research: 1955-2004." In Response Surface Methodology and Related Topics, edited by A.I. Khuri. 283-327. Singapore:World Scientific Press. PNWD-SA-6707.
  • Piepel G.F. 2006. "A Note Comparing Component-Slope, Scheffé, and Cox Parameterizations of the Linear Mixture Experiment Model." Journal of Applied Statistics 33, no. 4:397-403. PNNL-SA-45662.

2005

  • Nguyen N.K., and G.F. Piepel. 2005. "Computer-Generated Experimental Designs for Irregular-Shaped Regions." Quality Technology and Quantitative Management 2, no. 2:147-160. PNNL-SA-45165.
  • Piepel G.F., S.K. Cooley, and B. Jones. 2005. "Construction of a 21-Component Layered Mixture Experiment Design Using a New Mixture Coordinate-Exchange Algorithm." Quality Engineering 17, no. 4:579-594. PNNL-SA-37340.

2004

  • Piepel G.F., S.K. Cooley, and B. Jones. 2004. Construction of a 21-Component Layered Mixture Experiment Design. PNNL-14862. Richland, WA: Pacific Northwest National Laboratory.

2003

  • Cooley S.K., G.F. Piepel, H. Gan, W. Kot, and I.L. Pegg. 2003. "A Two-Stage Layered Mixture Experiment Design for a Nuclear Waste Glass Application-Part 1." In 2003 ASA Proceedings. Papers presented at the Annual Meeting of the American Statistical Association. Joint Statistical Meetings, San Francisco, California, August 3-7, 2003, 1036-1043. Alexandria, Virginia:American Statistical Association. PNWD-SA-6275.
  • Cooley S.K., G.F. Piepel, H. Gan, W. Kot, and I.L. Pegg. 2003. "A Two-Stage Layered Mixture Experiment Design for a Nuclear Waste Glass Application-Part 2." In 2003 ASA Proceedings. Papers presented at the Annual Meeting of the American Statistical Association. Joint Statistical Meetings, San Francisco, California, August 3-7, 2003, 1044-1051. Alexandria, Virginia:American Statistical Association. PNWD-SA-6277.

2002

  • Piepel G.F., J.M. Szychowski, and J.L. Loeppky. 2002. "Augmenting Scheffe Linear Mixture Models With Squared and/or Crossproduct Terms." Journal of Quality Technology 34, no. 3:297-314. PNNL-SA-33717.
  • Piepel G.F., R.D. Hicks, J.M. Szychowski, and J.L. Loeppky. 2002. "Methods for Assessing Curvature and Interaction in Mixture Experiments." Technometrics 44, no. 2:161-172. PNNL-SA-33172.
  • Piepel G.F., S.K. Cooley, D.K. Peeler, J.D. Vienna, and T.B. Edwards. 2002. "Augmenting a Waste Glass Mixture Experiment Study with Additional Glass Components and Experimental Runs." Quality Engineering 15, no. 1:91-111. PNNL-SA-36766.
  • Smith G.L., H.D. Smith, M.J. Schweiger, and G.F. Piepel. 2002. "Vitrification and Testing of Hanford Pretreated Low Activity Waste." In Environmental Issues and Waste Management Technologies in the Ceramic and Nuclear Industries VII, proceedings, 103rd Annual Meeting of The American Ceramic Society, held April 22-25, 2001, in Indianapolis, Indiana, USA., edited by Gary L. Smith, S.K. Sundaram, and Dane R. Spearing, 132, 129-140. Westerville, Ohio:The American Ceramic Society. PNWD-SA-5379.

2001

  • Hrma P.R., G.F. Piepel, J.D. Vienna, S.K. Cooley, D. Kim, and R.L. Russell. 2001. Database and Interim Glass Property Models for Hanford HLW Glasses. PNNL-13573. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F., H. Li, C.F. Windisch, Y. Su, and M.L. Elliott. 2001. "Statistical Modeling of Raman Spectroscopy Data from High-Temperature Glass Melts for On-Line Monitoring of Temperature and Composition." Quality Engineering 13, no. 4:667-677. PNNL-SA-34690.
  • Smith G.L., D.J. Bates, R.W. Goles, L.R. Greenwood, R.C. Lettau, G.F. Piepel, and M.J. Schweiger, et al. 2001. Vitrification and Product Testing of C-104 and AZ-102 Pretreated Sludge Mixed with Flowsheet Quantities of Secondary Wastes. PNNL-13452. Richland, WA: Pacific Northwest National Laboratory.

2000

  • Hrma P.R., J.D. Vienna, J.V. Crum, G.F. Piepel, and M. Mika. 2000. "Liquidus Temperature of High-Level Waste Borosilicate Glasses with Spinel Primary Phase." In Scientific Basis for Nuclear Waste Management XXIII, Materials Research Society Symposium Proceedings, edited by Robert W. Smith; David W. Shoesmith, 608, 671-676. Warrendale, Pennsylvania:Materials Research Society. PNNL-SA-32484.
  • Piepel M.G., and G.F. Piepel. 2000. "How Soil Composition Affects Density and Water Capacity-A Science Fair Project Using Mixture Experiment Methods." Stats 28. PNNL-SA-30188.
  • Smith G.L., L.R. Greenwood, G.F. Piepel, M.J. Schweiger, H.D. Smith, M.W. Urie, and J.J. Wagner. 2000. Vitrification and Product Testing of AW-101 and AN-107 Pretreated Waste. PNNL-13372. Richland, WA: Pacific Northwest National Laboratory.

1999

  • Hrma P.R., J.D. Vienna, M. Mika, J.V. Crum, and G.F. Piepel. 1999. Liquidus Temperature Data for DWPF Glass. PNNL-11790. Richland, WA: Pacific Northwest National Laboratory.
  • Piepel G.F. 1999. "Modeling Methods for Mixture-of-Mixtures Experiments Applied to a Tablet Formulation Problem." Pharmaceutical Development and Technology 4, no. 4:593-606. PNWD-SA-4593.

1998

  • Li H., G.F. Piepel, C.F. Windisch, Y. Su, and M.L. Elliott. 1998. Feasibility Study of Using High-Temperature Raman Spectroscopy for On-Line Monitoring and Product Control of the Glass Vitrification Process. PNNL-12037. Richland, WA: Pacific Northwest National Laboratory.

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