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Staff information

Ying Zhu

Scientific & Computing Operations
Post Doctorate RA B
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-91
Richland, WA 99352


Dr. Zhu is a postdoc research associate in Environmental Molecular Sciences Laboratory and working tightly with Integrative Omics group of Biological Sciences Directorate.

His project is to develop new technology for in-depth proteome mapping of tumor microenvironment with single-cell resolution. He invented the nanoPOTS (Nanodroplet Processing in One pot for Trace Samples) platform, which combined microfluidics, robotics, and ultrasensitive LC-MS systems to achieve single cell analysis of protein expression in single cells.

Research Interests

  • Microfluidic techniques for chemical and biological research
  • Automation of liquid handling for sample preparation and LC-MS analysis
  • Proteomic analysis of single cells

PNNL Publications


  • Geng T, CR Smallwood, Y Zhu, EL Bredeweg, SE Baker, JE Evans, and RT Kelly. 2017. "Multimodal Microchannel and Nanowell-Based Microfluidic Platforms for Bioimaging." In Proceedings of the 10th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2016), October 30- November 2, 2016, Macau, China, pp. 155-158.  IEEE, PISCATAWAY, NJ.  doi:10.1109/NANOMED.2016.7883480
  • Huang CM, Y Zhu, DQ Jin, RT Kelly, and Q Fang. 2017. "Direct Surface and Droplet Microsampling for Electrospray Ionization Mass Spectrometry Analysis with an Integrated Dual-Probe Microfluidic Chip." Analytical Chemistry 89(17):9009-9016.  doi:10.1021/acs.analchem.7b01679

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