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Staff information

Mowei Zhou

Biosystms Dynamics & Simula
Post Doctorate RA B
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352


Dr. Zhou is a post-doctoral research assistant in Dr. Ljiljana Pasa-Tolic’s group. His research focuses on using high resolution mass spectrometry techniques for protein structural analysis.Dr. Zhou is involved in projects utilizing top-down mass spectrometry for protein identification and characterization. One major research interest with top-down mass spectrometry at EMSL is to characterize histone post-translational modification that controls gene expression on the intact protein level (e.g. combinatorial histone codes) in biological samples. He is also working on native mass spectrometry techniques where intact noncovalent protein complexes are directly analyzed in the gas phase for structural characterization.

Research Interests

  • Native and top-down mass spectrometry for structural elucidation of protein structure.

Education and Credentials

  • 2013 Analytical Chemistry, Ohio State University
  • 2008-2012 Doctoral Student in Analytical Chemistry, University of Arizona
  • 2008 B.S. Degree in Chemistry, Wuhan University, China

Affiliations and Professional Service

  • Member of the American Society for Mass Spectrometry

Awards and Recognitions

  • 2012, April; College of Science Galileo Circle Scholarship, University of Arizona

PNNL Publications


  • Park JK, PD Piehowski, CS Wilkins, M Zhou, JA Mendoza, GM Fujimoto, BC Gibbons, JB Shaw, Y Shen, AK Shukla, RJ Moore, T Liu, VA Petyuk, N Tolic, L Pasa Tolic, RD Smith, SH Payne, and S Kim. 2017. "Informed-Proteomics: Open Source Software Package for Top-down Proteomics." Nature Methods 14(9):909-914.  doi:10.1038/nmeth.4388
  • Romano CA, M Zhou, Y Song, VH Wysocki, A Dohnalkova, L Kovarik, L Pasa Tolic, and BM Tebo. 2017. "Biogenic manganese oxide nanoparticle formation by a multimeric multicopper oxidase Mnx." Nature Communications 8:746.  doi:10.1038/s41467-017-00896-8
  • Yan J, M Zhou, J Gilbert, JJ Wolff, A Somogyi, RE Pedder, RS Quintyn, L Morrison, ML Easterling, L Pasa Tolic, and VH Wysocki. 2017. "Surface-induced dissociation of protein complexes in a hybrid Fourier transform ion cyclotron resonance mass spectrometer." Analytical Chemistry 89(1):895-901.  doi:10.1021/acs.analchem.6b03986
  • Zhou M, L Pasa Tolic, and DL Stenoien. 2017. "Profiling of Histone Post-translational Modifications in Mouse Brain with High Resolution Top Down Mass Spectrometry." Journal of Proteome Research 16(2):599-608.  doi:10.1021/acs.jproteome.6b00694


  • Zhou M, S Wu, DL Stenoien, Z Zhang, L Connolly, M Freitag, and L Pasa-Tolic. 2016. "Profiling Changes in Histone Post-translational Modifications by Top-Down Mass Spectrometry." Chapter 12 in Methods in Molecular Biology: Eukaryotic transcriptional and post-transcriptional gene expression regulation, vol. 1507, ed. N Wajapeyee and R Gupta, pp. 153-168.  Springer, NEW YORK, NY.  doi:10.1007/978-1-4939-6518-2_12

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