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Staff information


Chun-Long Chen

Hierarchial Materials Team
Materials Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: K4-18
Richland, WA 99352


Dr. Chun-Long Chen is currently a senior research scientist at Pacific Northwest National Laboratory (PNNL). His research focuses on developing sequence-defined synthetic polymers to mimic natural proteins for biomimetic mineralization and for assembly of porous materials with clean energy applications. He received his Ph.D. degree in physical inorganic chemistry from Sun Yat-Sen (Zhongshan) University in China. His doctoral research was focused on the design and assembly of metallo-supramolecules and the study of their formation mechanisms and structural dynamics. Since then, he has worked extensively on the applications of "bottom-up" assembly approaches, including the assembly of protein and protein-mimetic materials for biomimetic mineralization, and the assembly of complex nanoparticle superstructures by combining peptide self-assembly and peptide-directed mineralization. Throughout his career Dr. Chen has built extensive experience in both synthetic chemistry and materials science, developing a highly interdisciplinary approach to achieve the rational design and assembly of biomimetic materials. Dr. Chen has published more than 50 papers with three US patents.

Research Interests

  • Peptoid synthesis and self-assembly
  • Biomimetic mineralization
  • In situ AFM imaging
  • Chemical biology

Education and Credentials

  • PhD, Sun Yat-Sen(Zhongshan) University, 2005
  • BS, Nanchang University, 2000

Affiliations and Professional Service

  • Materials Research Society
  • American Chemical Society

Awards and Recognitions

  • DARPA Fold F(x) Program Award, A Synthetic Immune System based on Peptoid NanoSwatches, (Co-PI) (2014)
  • Laboratory Directed Research and Development (LDRD) Award (PI) (2013)
  • Young Investigator Award, 10th International Conference on the Chemistry and Biology of Mineralized Tissues (ICCBMT) (2010)
  • Best Poster Award, the 22nd American Conference on Crystal Growth and Epitaxy-West (2010)
  • NANYUE Award, Guangdong Province, China (2005)
  • KAISI Fellowship, Sun Yat-Sen University, China (2004)
  • SAMSUNG Award, Sun Yat-Sen University, China (2003)
  • DUPONT Award, Sun Yat-Sen University, China (2002)

PNNL Publications


  • Jiao F., X. Wu, T. Jian, S. Zhang, H. Jin, P. He, and C. Chen, et al. 2019. "Hierarchical Assembly of Peptoid-Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution." Angewandte Chemie International Edition 58, no. 5:12223-12230. PNNL-SA-148211. doi:10.1002/anie.201904598
  • Jin H., T. Jian, Y. Ding, Y. Chen, P. Mu, L. Wang, and C. Chen. 2019. "Solid-Phase Synthesis of Three-Armed Star-Shaped Peptoids and Their Hierarchical Self-Assembly." Biopolymers 110, no. 4:e23258. PNNL-SA-140649. doi:10.1002/bip.23258


  • Chen C. 2018. "Peptoid-based membrane-mimetic two dimensional nanomaterials." In Micro- and Nanotechnology Sensors, Systems, and Applications X, April 15-19, 2018,Orlando, Florida. Proceedings of the SPIE, edited by T George, AK Dutta and M Saif Islam, 10639, Aricle No. 106390X. Bellingham, Washington:SPIE. PNNL-SA-133246. doi:10.1117/12.2303685
  • Jin H., Y. Ding, M. Wang, Y. Song, Z. Liao, C.J. Newcomb, and X. Wu, et al. 2018. "Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids." Nature Communications 9. PNNL-SA-126066. doi:10.1038/s41467-017-02059-1
  • Merrill N.A., F. Yan, H. Jin, P. Mu, C. Chen, and M.R. Knecht. 2018. "Tunable Assembly of Biomimetic Peptoids as Templates to Control Nanostructure Catalytic Activity." Nanoscale 10, no. 26:12445-12452. PNNL-SA-135764. doi:10.1039/c8nr03852j
  • Mu P., G. Zhou, and C. Chen. 2018. "2D nanomaterials assembled from sequence-defined molecules." Nano-Structures & Nano-Objects 15. PNNL-SA-129009. doi:10.1016/j.nanoso.2017.09.010
  • Song Y., M. Wang, S. Li, H. Jin, X. Cai, D. Du, and C. Chen, et al. 2018. "Efficient Cytosolic Delivery Using Crystalline Nanoflowers Assembled from Fluorinated Peptoids." Small 14, no. 52:Article Number: 1803544. PNNL-SA-139291. doi:10.1002/smll.201803544
  • Yan F., L. Liu, T.R. Walsh, Y. Gong, P.Z. El-Khoury, Y. Zhang, and Z. Zhu, et al. 2018. "Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering." Nature Communications 9. PNNL-SA-118537. doi:10.1038/s41467-018-04789-2


  • Ma X., S. Zhang, F. Jiao, C.J. Newcomb, Y. Zhang, A. Prakash, and Z. Liao, et al. 2017. "Tuning crystallization pathways through sequence-engineering of biomimetic polymers." Nature Materials 16, no. 7:767-774. PNNL-SA-123850. doi:10.1038/nmat4891


  • Chen C., R. Zuckermann, and J.J. De Yoreo. 2016. "Surface-Directed Assembly of Sequence-Defined Synthetic Polymers into Networks of Hexagonally Patterned Nanoribbons with Controlled Functionalities." ACS Nano 10, no. 5:5314-5320. PNNL-SA-116103. doi:10.1021/acsnano.6b01333
  • Jiao F., Y. Chen, H. Jin, P. He, C. Chen, and J.J. De Yoreo. 2016. "Self-repair and Patterning of 2D Membrane-like Peptoid Materials." Advanced Functional Materials 26, no. 48:8960-8967. PNNL-SA-119504. doi:10.1002/adfm.201602365
  • Jin H., F. Jiao, M.D. Daily, Y. Chen, F. Yan, Y. Ding, and X. Zhang, et al. 2016. "Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids." Nature Communications 7. PNNL-SA-112006. doi:10.1038/ncomms12252


  • Chen C., J. Qi, J. Tao, R. Zuckermann, and J.J. De Yoreo. 2014. "Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics." Scientific Reports 4. PNNL-SA-102366. doi:10.1038/srep06266

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