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Staff information


Brian Thrall

Biological Sciences Division
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352


Dr. Brian Thrall is Associate Director within the Biological Sciences Division, Chief Scientist for Systems Toxicology, and Technical Group Manager for Health Impacts & Exposure Science at Pacific Northwest National Laboratory. Dr. Thrall also holds adjunct positions in the Graduate Research Program at Washington State University and regularly serves as a reviewer for panels for the National Institutes of Health in the area of proteomic and genomic analysis of the health effects of enviromental agents.

Dr. Thrall's laboratory currently focuses on understanding the mechanisms in which engineered nanonomaterials interact with cells and tissues. Using macrophages and a variety of epithelial cell types as models systems, his research employs genomic, proteomic, and cellular imaging approaches, coupled with computational biology strategies to identify the pathways modulated by nanoparticles and the implications of these pathways for human health. The goal of these studies is to identify fundamental principles which dictate biocompatibility of nanomaterials in order to guide safe and effective applications of these technologies.

Research Interests

  • Nanotoxicology
  • Modulation of cell signaling pathways by environmental agents

Education and Credentials

  • Ph.D., Pharmacology, Washington State University
  • M.A., Biology, University of South Dakota
  • B.S., Biology, University of South Dakota

Affiliations and Professional Service

  • American Society for Cell Biology
  • Society of Toxicology, Molecular Biology Specialty Section
  • Pacific Northwest Association of Toxicologist
  • American Association for the Advancement of Science

Science at PNNL

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