A multi-institution research team found how the protein environment surrounding some enzymes can alter the direction of a cellular reaction, as well as its rate—up to six orders of magnitude—in a phenomenon referred to as catalytic bias.
At PNNL, subsurface science inhabits two separate but interlocking worlds. One looks at basic science, the other at applied science and engineering. Both are funded by the U.S. Department of Energy (DOE).
With the help of a diagnostic tool called the Salish Sea Model, researchers found that toxic contaminant hotspots in the Puget Sound are tied to localized lack of water circulation and cumulative effects from multiple sources.
The world’s largest scientific society honored Sue B. Clark, a PNNL and WSU chemist, for contributions toward resolving our legacy of radioactive waste, advancing nuclear safeguards, and developing landmark nuclear research capabilities.
PNNL scientists have taken one of the most in-depth looks ever at the riot of protein activity that underlies colon cancer and have identified potential new molecular targets to try to stop the disease.
"It's sort of like using infrared goggles to see heat signatures in the dark, except this is underground." PNNL and CHPRC implemented a state-of-the-art approach to monitor the process of remediating residual uranium at Hanford's 300 Area.