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Biological Sciences

Human Pathogens

A representation of Salmonella in a systems biology context that can be understood as one might understand a watch or complex machine. Courtesy of Ken Auberry Enlarged View

Contact: Dr. Josh Adkins

PNNL leads a Center for System Biology of EnteroPathogens for the National Institute of Allergies and Infectious Diseases. This Center was established to deepen fundamental understanding of the complex processes of microbes and their interactions with the host.

Our systems approach involves the use of iterative steps with complementary computational and experimental "omics" methodologies to analyze, identify, quantify, model, and ultimately predict the overall molecular processes involved in the pathogenesis of Salmonella and Yersinia species within host cells.

Our premise is that knowledge gained from the coordinated analysis and modeling of these two genera within the family of Enterobacteria will lead to improved control and therapeutic treatment strategies not only for these specific pathogens, but also for related gram-negative bacteria.

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