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Biological Sciences

Low Dose Radiation Biology

Contact: Dr. William Morgan

In PNNL's Low Dose Radiation Biology research, experimental designs are developed to interrogate complex signaling in human skin tissue.

For the Department of Energy's Low Dose Radiation research program, researchers use an integrated, systems-level approach to understand the fundamental signaling events mediated by low dose and low dose rate radiation, focusing on the tissue response rather than individual cells. PNNL researchers are using a human skin tissue model system to address the hypothesis that the normal tissue response to low dose and low dose rate radiation supports homeostasis, and that this is achieved through intracellular signaling best understood through an integrated experimental and pathway modeling approach. These studies will provide a fundamental understanding of how low dose and low dose rate-induced signaling is coordinated through intercellular communication, and determine how these mechanisms impact the linearity of dose-response behavior at low doses.

See more about PNNL's Low Dose Radiation Research Program Scientific Focus Area, "Linear and Nonlinear Tissue-Signaling Mechanisms in Response to Low Dose and Low Dose-Rate Radiation."

Investigators: William F. Morgan, David L. Stenoien, Marianne B. Sowa, Thomas J. Weber, Katrina M. Waters

Selected Publications:

Yang F et al. 2012. "Quantitative Phosphoproteomics Identifies Filaggrin and other Targets of Ionizing Radiation in a Human Skin Model." Experimental Dermatology 21(5):352-357. DOI: 10.1111/j.1600-0625.2012.01470.x

Waters KM et al. 2012. "Annexin A2 Modulates Radiation-Sensitive Transcriptional Programming and Cell Fate." Radiation Research 179(1):56-61. DOI: 10.1667/RR3056.1

Shankaran H et al. 2012. "Using Imaging Methods to Interrogate Radiation-Induced Cell Signaling." Radiation Research 177(4):496-507. DOI: 10.1667/RR2669.1

Freiin von Neubeck CH et al. 2012. "Cell Type-dependent Gene Transcription Profile in Three Dimensional Human Skin Tissue Model Exposed to Low Doses of Ionizing Radiation: Implications for Medical Exposures." Environmental and Molecular Mutagenesis 53(4):247-259. DOI: 10.1002/em.21682

Hu Z et al. 2012. "Metabolomic Response of Human Skin Tissue to Low Dose Ionizing Radiation." Molecular Biosystems 8(7):1979-1986. DOI: 10.1039/C2MB25061F

Miller JH et al. 2011. "Simulation of Electron-Beam Irradiation of Skin Tissue Model." Radiation Research 175(1):113-118. DOI: 10.1667/RR2339.1

Miller JH, WB Chrisler, X Wang, and MB Sowa. 2011. "Confocal Microscopy for Modeling Electron Microbeam Irradiation of Skin." Radiation and Environmental Biophysics 50(3):365-369. DOI: 10.1007/s00411-011-0371-z

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