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Fundamental and Computational Sciences Directorate

Staff information

Alejandro Heredia-Langner

Applied Statistics & Mathematics
Pacific Northwest National Laboratory
PO Box 999
MSIN: K7-20
Richland, WA 99352

PNNL Publications


  • Bartholomew RA, RM Ozanich, JS Arce, HE Engelmann, A Heredia-Langner, BA Hofstad, JR Hutchison, KH Jarman, AM Melville, KD Victry, and CJ Bruckner-Lea. 2017. "Evaluation of Immunoassays and General Biological Indicator Tests for Field Screening of Bacillus anthracis and Ricin." Health Security 15(1):81-96.  doi:10.1089/hs.2016.0044
  • Mo KF, A Heredia-Langner, and CG Fraga. 2017. "Evaluating and Modeling the Effects of Surface Sampling Factors on the Recovery of Organic Chemical Attribution Signatures using the Accelerated Diffusion Sampler and Solvent Extraction." Talanta 164:92-99.  doi:10.1016/j.talanta.2016.11.016
  • Ozanich RM, HA Colburn, KD Victry, RA Bartholomew, JS Arce, A Heredia-Langner, KH Jarman, HW Kreuzer, and CJ Bruckner-Lea. 2017. "Evaluation of PCR Systems for Field Screening of Bacillus anthracis." Health Security 15(1):70-80.  doi:10.1089/hs.2016.0043


  • Bond-Lamberty B, H Bolton, Jr, SJ Fansler, A Heredia-Langner, C Liu, LA McCue, JL Smith, and VL Bailey. 2016. "Soil respiration and bacterial structure and function after 17 years of a reciprocal soil transplant experiment." PLoS One 11(3):e0150599.  doi:10.1371/journal.pone.0150599
  • Fraga CG, K Bronk, BP Dockendorff, and A Heredia-Langner. 2016. "Organic Chemical Attribution Signatures for the Sourcing of a Mustard Agent and its Starting Materials." Analytical Chemistry 88(10):5406-5413.  doi:10.1021/acs.analchem.6b00766
  • Mitchell HD, LM Markillie, WB Chrisler, MJ Gaffrey, D Hu, CJ Szymanski, Y Xie, ES Melby, A Dohnalkova, RC Taylor, EK Grate, SK Cooley, JE McDermott, A Heredia-Langner, and G Orr. 2016. "Cells Respond to Distinct Nanoparticle Properties with Multiple Strategies as Revealed by Single-Cell RNA-Seq." ACS Nano 10(11):10173-10185.  doi:10.1021/acsnano.6b05452


  • Bamberger JA, GF Piepel, CW Enderlin, BG Amidan, and A Heredia-Langner. 2015. "Experimental and Measurement Uncertainty Associated with Characterizing Slurry Mixing Performance of Pulsating Jets at Multiple Scales." In ASME-JSME-KSME Joint Fluids Engineering Conference, Symposium on Uncertainty Quantification in Flow Measurements and Simulations, July 26-31, 2015, Seoul, Korea , vol. 1, no. Paper No. AJKFluids2015-27575, p. V001T27A002.  American Society of Mechanical Engineers, New York, NY.  doi:10.1115/AJKFluids2015-27575
  • Harper B, DG Thomas, S Chikkagoudar, NA Baker, K Tang, A Heredia-Langner, RD Lins, and S Harper. 2015. "Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity." Journal of Nanoparticle Research 17(6):Article No. 250.  doi:10.1007/s11051-015-3051-0
  • Heredia-Langner A, LR Rodriguez, A Lin, and JB Webster. 2015. "Selecting a Classification Ensemble and Detecting Process Drift in an Evolving Data Stream." In DMIN'15: The 11th International Conference on Data Mining, July 27-30, 2015, Las Vegas, Nevada, ed. R Stahlbock, et al, pp. 31-36.  CSREA Press, ATHENS, GA. 
  • Matzner S, A Heredia-Langner, BG Amidan, EJ Boettcher, D Lochtefeld, and T Webb. 2015. "Standoff Human Identification Using Body Shape." In IEEE International Symposium on Technologies for Homeland Security (HST 2015), April 14-16, 2015, Waltham, Massachusetts, pp. 1-6.  IEEE, Piscataway, NJ.  doi:10.1109/THS.2015.7225300


  • Ewing RG, A Heredia-Langner, and MG Warner. 2014. "Optimizing detection of RDX vapors using designed experiments for remote sensing." The Analyst 139(10):2440-2448.  doi:10.1039/C4AN00125G
  • Heredia-Langner A, BG Amidan, S Matzner, and KH Jarman. 2014. "Optimization of an individual re-identification modeling process using biometric features." In Proceedings of the International Conference on Data Mining (DMIN 2014), July 21-24, 2014, Las Vegas, Nevada, ed. R Stahlbock, GM Weiss, M Abou-Nasr and H Arabnia.  CSREA Press, ATHENS, GA. 
  • Piepel GF, AE Holmes, A Heredia-Langner, KP Lee, and SE Kelly. 2014. Scaling Relationships Based on Scaled Tank Mixing and Transfer Test Results PNNL-22644 Rev. 1, Pacific Northwest National Laboratory, Richland, WA. 
  • Thomas DG, S Chikkagoudar, A Heredia-Langner, MF Tardiff, Z Xu, D Hourcade, C Pham, GM Lanza, KQ Weinberger, and NA Baker. 2014. "Physicochemical signatures of nanoparticle-dependent complement activation." Computational Science and Discovery 7(1):Article No. 015003.  doi:10.1088/1749-4699/7/1/015003


  • Daily MD, J Chun, A Heredia-Langner, G Wei, and NA Baker. 2013. "Origin of parameter degeneracy and molecular shape relationships in geometric-flow calculations of solvation free energies." Journal of Chemical Physics 139(20):Article No. 204108.  doi:10.1063/1.4832900
  • Heredia-Langner A, KH Jarman, BG Amidan, and JG Pounds. 2013. "Genetic Algorithms and Classification Trees in Feature Discovery: Diabetes and the NHANES database." In Proceedings of the 2013 World Congress in Computer Science, Computer Engineering, and Applied Computing (WORLDCOMP'13), July 22-25, 2013, Las Vegas, Nevada.  CSREA Press, Athens, GA. 
  • Piepel GF, AE Holmes, and A Heredia-Langner. 2013. Scaling Relationships Based on Scaled Tank Mixing and Transfer Test ResultsPNNL-22644, Pacific Northwest National Laboratory, Richland, WA. 



  • Zhang H, KE Burnum, ML Luna, BO Petritis, JS Kim, W Qian, RJ Moore, A Heredia-Langner, BJM Webb-Robertson, BD Thrall, DG Camp, II, RD Smith, JG Pounds, and T Liu. 2011. "Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size." Proteomics 11(23):4569-4577.  doi:10.1002/pmic.201100037


  • Amidan BG, GF Piepel, A Heredia-Langner, PA Meyer, BE Wells, JA Fort, JA Bamberger, and WL Kuhn. 2010. "A STATISTICAL INTELLIGENCE (STI) APPROACH TO DISCOVERING SPURIOUS CORRELATION IN A PHYSICAL MODEL AND RESOLVING THE PROBLEM WITH AN EXAMPLE OF DESIGNING A PULSE JET MIXING SYSTEM AT HANFORD." In Proceedings of PVP2010: ASME Pressure Vessels & Piping Conference Pressure Vessel Technology for Energy Challenge, July 18-22, 2010, Bellevue, Washington, pp. Paper No. PVP2010-25817.  ASME , New York, NY. 


  • Matyas J, SK Sundaram, CP Rodriguez, A Heredia-Langner, and BM Arrigoni. 2009. "Viscosity measurements and empirical predictions for coal slags." In 26th International Pittsburgh Coal Conference: Coal - Energy, Environment and Sustainable Development, September 20-23, 2009, Pittsburgh, Pennsylvania, p. 9 pages.  Pittsburgh Coal Conference, Univ. of Pittsburgh, Pittsburgh, PA. 
  • Meyer PA, JA Bamberger, CW Enderlin, JA Fort, BE Wells, SK Sundaram, PA Scott, MJ Minette, GL Smith, CA Burns, MS Greenwood, GP Morgen, EBK Baer, SF Snyder, M White, GF Piepel, BG Amidan, A Heredia-Langner, SA Bailey, JC Bower, KM Denslow, DE Eakin, MR Elmore, PA Gauglitz, AD Guzman, BK Hatchell, DF Hopkins, DE Hurley, MD Johnson, LJ Kirihara, BD Lawler, JS Loveland, OD Mullen, MS Pekour, TJ Peters, PJ Robinson, MS Russcher, S Sande, C Santoso, SV Shoemaker, SM Silva, DE Smith, YF Su, JJ Toth, JD Wiberg, XY Yu, and N Zuljevic. 2009. Pulse Jet Mixing Tests With Noncohesive SolidsPNNL-18098, Pacific Northwest National Laboratory, Richland, WA. 


  • Piepel GF, A Heredia-Langner, and SK Cooley. 2008. "Property-Composition-Temperature Modeling of Waste Glass Melt Data Subject to a Randomization Restriction ." Journal of the American Ceramic Society 91(10):3222-3228.  doi:10.1111/j.1551-2916.2008.02590.x


  • Jarman KD, LE Smith, A Heredia-Langner, AS Renholds, WR Kaye, and SD Miller. 2005. "Optimal Design of Passive Gamma-Ray Spectrometers." In Nuclear Science Symposium Conference Record, 2005 IEEE, vol. 2, pp. 1062-1066.  Institute of Electrical and Electronics Engineers, Inc. (IEEE), Los Alamitos, CA.  doi:10.1109/NSSMIC.2005.1596435
  • Cannon WR, KH Jarman, BJM Webb-Robertson, DJ Baxter, CS Oehmen, KD Jarman, A Heredia-Langner, KJ Auberry, and GA Anderson. 2005. "A Comparison of Probability and Likelihood Models for Peptide Identification from Tandem Mass Spectrometry Data." Journal of Proteome Research 4(5):1687-1698. 
  • Malard JM, A Heredia-Langner, WR Cannon, RW Mooney, and DJ Baxter. 2005. "Peptide identification via constrained multi-objective optimization: Pareto-based genetic algorithms ." Concurrency and Computation. Practice & Experience 17(14):1687-1704. 
  • Smith LE, AR Swickard, A Heredia-Langner, GA Warren, ER Siciliano, and SD Miller. 2005. "Design Considerations for Passive Gamma-Ray Spectrometers." In 2004 IEEE Nuclear Science Symposium Conference Record 16-22 October 2004 Rome, Italy., vol. 3, ed. Seibert, J. Anthony, pp. 1571-1575.  IEEE, Piscataway, NJ.  doi:10.1109/NSSMIC.2004.1462540
  • Smith LE, AR Swickard, A Heredia-Langner, GA Warren, ER Siciliano, and SD Miller. 2005. "Design Considerations for Passive Gamma-Ray Spectrometers." In 2004 IEEE Nuclear Science Symposium Conference Record, vol. 3, pp. 1571-1575.  IEEE, Piscataway, NJ.  doi:10.1109/NSSMIC.2004.1462540
  • Thompson SE, A Heredia-Langner, TJ Johnson, NS Foster, NB Valentine, and JE Amonette. 2005. "Statistical Analysis of Noisy Signals Using Classification Tools." In ASQ World Conference on Quality and Improvement Proceedings, vol. 59, pp. 333-334.  American Society for Quality, Milwaukee, WI. 


  • Heredia-Langner A, DC Montgomery, WM Carlyle, and CM Borror. 2004. "Model-Robust Optimal Designs: A Genetic Algorithm Approach." Journal of Quality Technology 36(3):263-279. 
  • Heredia-Langner A, WR Cannon, KD Jarman, and KH Jarman. 2004. "De Novo Analysis of Tandem Mass Spectrometry Data as a Non-Deterministic Optimization Problem." In Proceedings of The International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences (METMBS'04), ed. Faramarz Valafar & Homayoun Valafar, pp. 113-117.  CSREA Press, Las Vegas, NV. 
  • Heredia-Langner A, WR Cannon, KD Jarman, and KH Jarman. 2004. "Sequence optimization as an alternative to de novo analysis of tandem mass spectrometry data." Bioinformatics 20(14):2296-2304. 
  • Malard JM, A Heredia-Langner, DJ Baxter, KH Jarman, and WR Cannon. 2004. "Constrained De-Novo Peptide Identification via Multi-objective Optimization." In Proceedings of the 18th International Parallel and Distributed Processing Symposium, pp. 191-199.  Institute of Electrical and Electronics Engineers, Piscataway, NJ. 
  • Ortiz F, JR Simpson, JJ Pignatiello, and A Heredia-Langner. 2004. "A Genetic Algorithm Approach to Multiple-Response Optimization." Journal of Quality Technology 36(4):432-450. 
  • Smith LE, AR Swickard, A Heredia-Langner, GA Warren, ER Siciliano, and SD Miller. 2004. "Design Considerations for Passive Gamma-Ray Spectrometers." IEEE Transactions on Nuclear Science 52(5):1721 - 1727 .  doi:10.1109/TNS.2005.856809


  • Heredia-Langner A, WM Carlyle, DC Montgomery, CM Borror, and GC Runger. 2003. "Genetic algorithms for the construction of D-optimal designs." Journal of Quality Technology 35(1):28-46. 
  • Jarman KD, WR Cannon, KH Jarman, and A Heredia-Langner. 2003. "A model of random sequences for de novo peptide sequencing." In Proceedings of the 3rd IEEE International Symposium on Bioinformatics and Bioengineering, pp. 206-213.  IEEE Computer Society, Los Alamitos, CA. 


  • Heredia-Langner A, DC Montgomery, and WM Carlyle. 2002. "Solving a multistage partial inspection problem using genetic algorithms ." International Journal of Production Research 40(8):1923-1940. 
  • Borror CM, A Heredia-Langner, and DC Montgomery. 2002. "Generalized linear models in the analysis of industrial experiments." Journal of Propagations in Probability and Statistics 2(2):127-143. 

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