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Fundamental and Computational Sciences Directorate

Staff information

Justin Teeguarden

Biological Sciences Division
Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352

PNNL Publications

2013

  • Shankaran H, F Adeshina, and JG Teeguarden. 2013. "Physiologically-Based Pharmacokinetic Model for Fentanyl in Support of the Development of Provisional Advisory Levels." Toxicology and Applied Pharmacology 273(13):002464-476.  doi:10.1016/j.taap.2013.05.024
  • Teeguarden JG, and S Hanson-Drury. 2013. "A Systematic Review of Bisphenol A "Low Dose" Studies in the Context of Human Exposure: A Case for Establishing Standards for Reporting "Low- Dose" Effects of Chemicals." Food and Chemical Toxicology 62:935-948.  doi:10.1016/j.fct.2013.07.007
  • Teeguarden JG, C Housand, JN Smith, PM Hinderliter, R Gunawan, and C Timchalk. 2013. "A Multi-Route Model of Nicotine-Cotinine Pharmacokinetics, Pharmacodynamics and Brain Nicotinic Acetylcholine Receptor Binding in Humans." Regulatory Toxicology and Pharmacology 65(1):12-28.  doi:10.1016/J.YRTPH.2012.10.007
  • Teeguarden JG, J Fisher, and DR Doerge. 2013. "Exposure Conditions and Pharmacokinetic Principles: Interpreting Bisphenol A Absorption in the Canine Oral Cavity." Environmental Health Perspectives 121(11-12):A323-A323.  doi:10.1289/ehp.1307424
  • Teeguarden JG, S Hanson-Drury, JW Fisher, and DR Doerge. 2013. "Are Typical Human Serum BPA Concentrations Measureable and Sufficient to be Estrogenic in the General Population?" Food and Chemical Toxicology 62:949-963.  doi:10.1016/j.fct.2013.08.001
  • DeWoskin RD, LM Sweeney, JG Teeguarden, R Sams, and J Vandenberg. 2013. "Comparison of PBTK Model and Biomarker Based Estimates of the Internal Dosimetry of Acrylamide." Food and Chemical Toxicology 58:506-521.  doi:10.1016/j.fct.2013.05.008
  • Kodali VK, MH Littke, SC Tilton, JG Teeguarden, L Shi, CW Frevert, W Wang, JG Pounds, and BD Thrall. 2013. "Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles." ACS Nano 7(8):6997-7010.  doi:10.1021/nn402145t
  • Minard KR, MH Littke, W Wang, Y Xiong, JG Teeguarden, and BD Thrall. 2013. "Magnetic Particle Detection (MPD) for In-Vitro Dosimetry." Biosensors and Bioelectronics 43:88-93.  doi:10.1016/j.bios.2012.12.011
  • Sharma G, VK Kodali, MJ Gaffrey, W Wang, KR Minard, NJ Karin, JG Teeguarden, and BD Thrall. 2013. "Iron Oxide Nanoparticle Agglomeration Influences Dose-Rates and Modulates Oxidative Stress Mediated Dose-Response Profiles In Vitro." Nanotoxicology 8(6):663-675.  doi:10.3109/17435390.2013.822115

2012

  • Teeguarden JG, A Calafat, and DR Doerge. 2012. "Adhering to Fundamental Principles of Biomonitoring, BPA Pharmacokinetics, and Mass Balance is no "Flaw"." Toxicological Sciences 125(1):321-325.  doi:10.1093/toxsci/kfr275
  • Karakoti AS, P Munusamy, KE Hostetler, VK Kodali, SVNT Kuchibhatla, G Orr, JG Pounds, JG Teeguarden, BD Thrall, and DR Baer. 2012. "Preparation and Characterization Challenges to Understanding Environmental and Biological Impacts of Ceria Nanoparticles." Surface and Interface Analysis 44(8):881-889.  doi:10.1002/sia.5006
  • Thrall BD, KR Minard, JG Teeguarden, and KM Waters. 2012. Multiscale Toxicology - Building the Next Generation Tools for ToxicologyPNNL-21916, Pacific Northwest National Laboratory, Richland, WA. 
  • Xie Y, NG Williams, A Tolic, WB Chrisler, JG Teeguarden, BL Maddux, JG Pounds, A Laskin, and G Orr. 2012. "Aerosolized ZnO nanoparticles induce toxicity in alveolar type II epithelial cells at the air-liquid interface." Toxicological Sciences 125(2):450-461.  doi:10.1093/toxsci/kfr251

2011

  • Teeguarden JG, A Calafat, X Ye, DR Doerge, MI Churchwell, R Gunawan, and MK Graham. 2011. "Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure." Toxicological Sciences 123(1):48-57.  doi:10.1093/toxsci/kfr160
  • Baer DR, AS Karakoti, P Munusamy, BD Thrall, JG Pounds, JG Teeguarden, JE Amonette, G Orr, PG Tratnyek, and JT Nurmi. 2011. "Testing in EHS: What is the Current Status of Experimentation?" In 11th IEEE International Conference on Nanotechnology (IEEE-NANO 2011), August 15-18, 2011, Portland, Oregon, pp. 18-19.  IEEE, Piscataway, NJ.  doi:10.1109/NANO.2011.6144671
  • Hanns-Rudolf P, FR Cassee, JG Teeguarden, H Fissan, S Diabate, M Aufderheide, WG Kreyling, O Hanninen, G Kasper, M Riediker, B Rothen-Rutishauser, and O Schmid. 2011. "In-vitro Cell Exposure Studies for the Assessment of Nanoparticle Toxicity in the Lung - A Dialogue between Aerosol Science and Biology." Journal of Aerosol Science 42(10):668-692.  doi:10.1016/j.jaerosci.2011.06.005
  • Teeguarden JG, BJM Webb-Robertson, KM Waters, A Murray, E Kisin, SM Varnum, JM Jacobs, JG Pounds, RC Zangar, and A Shvedova. 2011. "Comparative Proteomics and Pulmonary Toxicity of Instilled Single Walled Carbon Nanotubes, Crocidolite Asbestos and Ultrafine Carbon Black in Mice." Toxicological Sciences 120(1):123-135.  doi:10.1093/toxsci/kfq363

2010

  • Hinderliter PM, KR Minard, G Orr, WB Chrisler, BD Thrall, JG Pounds, and JG Teeguarden. 2010. "ISDD: A Computational Model of Particle Sedimentation, Diffusion and Target Cell Dosimetry for In Vitro Toxicity Studies." Particle and Fibre Toxicology 7(November):Article No. 36.  doi:10.1186/1743-8977-7-36

2009

  • Crump KS, and JG Teeguarden. 2009. "Benchmark calculations from summarized data: an example." Environmental and Ecological Statistics 16(1):13-24. 
  • Waters KM, LM Masiello, RC Zangar, BJ Tarasevich, NJ Karin, RD Quesenberry, S Bandyopadhyay, JG Teeguarden, JG Pounds, and BD Thrall. 2009. "Macrophage Responses to Silica Nanoparticles are Highly Conserved Across Particle Sizes." Toxicological Sciences 107(2):553-569. 

2008

  • Teeguarden JG, A Gupta, P Escobar, and M Jackson. 2008. "Toxicology steps up to nanotechnology safety." Research & Development 50(1):28-29. 
  • Teeguarden JG, MS Bogdanffy, TR Covington, C Tan, and AM Jarabek. 2008. "A PBPK Model for Evaluating the Impact of Aldehyde Dehydrogenase Polymorphisms on Comparative Rat and Human Nasal Tissue Acetaldehyde Dosimetry ." Inhalation Toxicology 20(4):375-390.  doi:10.1080/08958370801903750

2007

  • Teeguarden JG, DC Dorman, A Nong, TR Covington, HJ Clewell, III, and ME Andersen. 2007. "Pharmacokinetic Modeling of Manganese II. Hepatic Processing after Ingestion and Inhalation." Journal of Toxicology and Environmental Health Part A 70(18):1505-1514.  doi:10.1080/15287390701384619
  • Teeguarden JG, DC Dorman, TR Covington, HJ Clewell, III, and ME Andersen. 2007. "Pharmacokinetic Modeling of Manganese I. Dose-Dependencies of Uptake and Elimination." Journal of Toxicology and Environmental Health Part A 70(18):1493-1504.  doi:10.1080/15287390701384601
  • Teeguarden JG, J Gearhart, HJ Clewell, III, TR Covington, A Nong, and ME Anderson. 2007. "Pharmacokinetic Modeling of Manganese III. Physiological Approaches Accounting for Background and Tracer Kinetics." Journal of Toxicology and Environmental Health Part A 70(18):1515-1526.  doi:10.1080/15287390701384635
  • Dutta D, SK Sundaram, JG Teeguarden, BJ Riley, LS Fifield, JM Jacobs, RS Addleman, GA Kaysen, BM Moudgil, and TJ Weber. 2007. "Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials." Toxicological Sciences 100(1):303-315.  doi:10.1093/toxsci/kfm217
  • Orr G, DJ Panther, JL Phillips, BJ Tarasevich, A Dohnalkova, D Hu, JG Teeguarden, and JG Pounds. 2007. "Submicron and Nanoscale Inorganic Particles Exploit the Actin Machinery to be Propelled Along Microvillilike Structures into Alveolar Cells." ACS Nano 1(5):463-475.  doi:10.1021/nn700149r
  • Teeguarden JG, PM Hinderliter, G Orr, BD Thrall, and JG Pounds. 2007. "Particokinetics In Vitro: Dosimetry Considerations for In Vitro Nanoparticle Toxicity Assessments." Toxicological Sciences 95(2):300-312.  doi:10.1093/toxsci/kfl165

2005

  • Teeguarden JG, JM Waechter, HJ Clewell, III, TR Covington, and HA Barton. 2005. "Evaluation of Oral and IntravenousRoute Pharmacokinetics, Plasma Protein Binding and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach." Toxicological Sciences 85(2):823-838.  doi:10.1093/toxsci/kfil135
  • Teeguarden JG, PJ Deisinger, TS Poet, JC English, WD Faber, HA Barton, RA Corley, and HJ Clewell, III. 2005. " Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid ." Toxicological Sciences 85(1):429-446. 

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