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Biological Sciences Staff information

Aaron Wright

Aaron Wright

Prototype & Pilot
Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352
509/372-5920

Research Interests

  • Activity-Based Proteomics
  • Spatiotemporal Proteomics
  • Chemical Biology
  • Neglected Tropical Diseases

Education and Credentials

  • Postdoctoral Research Fellow, The Scripps Research Institute
  • Ph.D., Organic Chemistry, The University of Texas
  • B.S., Chemistry, George Fox University

Affiliations and Professional Service

  • American Chemical Society
  • American Association for the Advancement of Science

Awards and Recognitions

  • California Breast Cancer Research Program Postdoctoral Fellow
  • Dorothy Banks Graduate Research Fellow
  • University of Texas Career Development Grant
  • Dick van Santen Award, American Chemical Society
  • Edwards-Holman Science Award
  • National Science Foundation - Research Experience for Undergraduates Fellow - The University of Washington

PNNL Publications

2014

  • Wiedner SD, LN Anderson, NC Sadler, WB Chrisler, VK Kodali, RD Smith, and AT Wright. 2014. "Organelle-Specific Activity-Based Protein Profiling in Living Cells." Angewandte Chemie International Edition 53(11):2919-2922.  doi:10.1002/anie.201309135
  • Ismail HM, PM O'Neill, D Hong, R Finn, C Henderson, AT Wright, B Cravatt, J Hemingway, and MJ Paine. 2014. "Pyrethroid Activity-Based Probes for Profiling Cytochrome P450 Activities Associated with Insecticide Interactions." Proceedings of the National Academy of Sciences of the United States of America 110(49):19766-19771.  doi:10.1073/pnas.1320185110
  • Ortega C, R Liao, LN Anderson, T Rustad, AR Ollodart, AT Wright, DR Sherman, and C Grundner. 2014. "Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch." PLoS Biology 12(1):Article No. e1001746.  doi:10.1371/journal.pbio.1001746
  • Sadler NC, MR Melnicki, MH Serres, ED Merkley, WB Chrisler, EA Hill, MF Romine, S Kim, EM Zink, S Datta, RD Smith, AS Beliaev, A Konopka, and AT Wright. 2014. "Live Cell Chemical Profiling of Temporal Redox Dynamics in a Photoautotrophic Cyanobacterium." ACS Chemical Biology 9(1):291-300.  doi:10.1021/cb400769v

2013

  • Anderson LN, DE Culley, BA Hofstad, LM Chauvigne-Hines, EM Zink, SO Purvine, RD Smith, SJ Callister, JM Magnuson, and AT Wright. 2013. "Activity-based protein profiling of secreted cellulolytic enzyme activity dynamics in Trichoderma reesei QM6a, NG14, and RUT-C30." Molecular Biosystems 9(12):2992-3000.  doi:10.1039/c3mb70333a
  • Ansong C, C Ortega, SH Payne, DH Haft, LM Chauvigne-Hines, MP Lewis, AR Ollodart, SO Purvine, AK Shukla, S Fortuin, RD Smith, JN Adkins, C Grundner, and AT Wright. 2013. "Identification of widespread adenosine nucleotide binding in Mycobacterium tuberculosis." Chemistry & Biology 20(1):123-133.  doi:10.1016/j.chembiol.2012.11.008
  • Crowell SR, A Sharma, S Amin, JJ Soelberg, NC Sadler, AT Wright, WM Baird, DE Williams, and RA Corley. 2013. "Impact of Pregnancy on the Pharmacokinetics of Dibenzo[def,p]chrysene in Mice." Toxicological Sciences 135(1):48-62.  doi:10.1093/toxsci/kft124
  • Wiedner SD, C Ansong, BJM Webb-Robertson, LM Pederson, S Fortuin, BA Hofstad, AK Shukla, EA Panisko, RD Smith, and AT Wright. 2013. "Disparate Proteome Responses of Pathogenic and Non-pathogenic Aspergilli to Human Serum Measured by Activity-Based Protein Profiling (ABPP)." Molecular & Cellular Proteomics. MCP 12(7):1791-1805.  doi:10.1074/mcp.M112.026534

2012

  • Wiedner SD, KE Burnum, LM Pederson, LN Anderson, S Fortuin, LM Chauvigne-Hines, AK Shukla, C Ansong, EA Panisko, RD Smith, and AT Wright. 2012. "Multiplexed Activity-based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes upon Exposure to Human Serum." Journal of Biological Chemistry 287(40):33447-33459.  doi:10.1074/jbc.M112.394106
  • Chauvigne-Hines LM, LN Anderson, HM Weaver, JN Brown, PK Koech, CD Nicora, BA Hofstad, RD Smith, MJ Wilkins, SJ Callister, and AT Wright. 2012. "Suite of Activity-Based Probes for Cellulose-Degrading Enzymes." Journal of the American Chemical Society 134(50):20521-20532.  doi:10.1021/ja309790w
  • Sadler NC, TE Angel, MP Lewis, LM Pederson, LM Chauvigne-Hines, SD Wiedner, EM Zink, RD Smith, and AT Wright. 2012. "Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice." PLoS One 7(10):Article No. e47996.  doi:10.1371/journal.pone.0047996
  • Wiedner SD, KE Burnum, LM Pederson, LN Anderson, S Fortuin, LM Chauvigne-Hines, AK Shukla, C Ansong, EA Panisko, RD Smith, and AT Wright. 2012. "Multiplexed Activity-Based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes Upon Exposure to Human Serum." Journal of Biological Chemistry 287(40):33447-33459.  doi:10.1074/jbc.M112.394106

Biological Sciences

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