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Biological Sciences Staff information

Bill Cannon

Bill Cannon

Deputy Division Director
Scientist, TL
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-18
Richland, WA 99352


Dr. Cannon is author of more than 50 technical publications in modeling and simulation, data analysis and proteomics. His graduate work was in statistical thermodynamics in the laboratory of J. Andrew McCammon studying molecular recognition proteins using molecular dynamics and Monte Carlo methods. His graduate work was in the laboratory of Steven J. Benkovic where he worked in both experimental and computational enzymology. Before joining PNNL, Dr. Cannon spent time at Monsanto working on high-throughput transcriptome data analysis and network inference. Since joining PNNL, Dr. Cannon has worked on statistical methods for integrating proteomics data with models, the use of supercomputers to maximize the identification of peptides and proteins from high throughput mass spectrometry assays, and the modeling and simulation of metabolic pathways.


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Research Interests

  • Computational biophysics, biochemistry and proteomics; Modeling and simulation including deterministic and stochastic simulation of metabolism; simulations of state; microbial metabolism; statistics, statistical mechanics and statistical proteomics data analysis; Cloud computing and high performance computing.

Education and Credentials

  • Bachelor of Arts, Chemistry, University of California, Santa Cruz
  • Doctorate, Biochemistry and Biophysics, University of Houston
  • Post-doctoral Scholar, Enzymology, Pennsylvania State University

Awards and Recognitions

  • 2013 Computational and Information Sciences Directorate Outstanding Performance Award
  • 2007 Computational and Information Sciences Directorate Outstanding Performance Award
  • 2003 FSD Outstanding Performance Award
  • 2004 FSD Outstanding Performance Award
  • 2000 Monsanto Outstanding Performance Award
  • 1995 NIH Post-doctoral National Research Service Award in Biophysical Chemistry
  • 1992 NIH Pre-doctoral National Research Service Award in Biophysics
  • 1990 Welch Foundation Graduate Award 1990, University of Houston
  • 1985 Honors in Chemistry, University of California

PNNL Publications








  • Cannon WR, and BJM Webb-Robertson. 2007. "Computational Proteomics: High-throughput Analysis for Systems Biology." In Biocomputing 2007. Proceedings of the Pacific Symposium, Maui, Hawaii, USA, 3 - 7 January 2007, ed. RB Altman, AK Dunker, L Hunter, T Murray & TE Klein, pp. 403-408.  World Scientific Publishing Company, Singapore, Singapore. 
  • Webb-Robertson BJM, and WR Cannon. 2007. "Current Trends in Computational Inference from Mass Spectrometry-based Proteomics." Briefings in Bioinformatics 8(5):304-317.  doi:10.1093/bib/bbm023



  • Malard JM, A Heredia-Langner, WR Cannon, RW Mooney, and DJ Baxter. 2005. "Peptide identification via constrained multi-objective optimization: Pareto-based genetic algorithms ." Concurrency and Computation. Practice & Experience 17(14):1687-1704. 


  • Heredia-Langner A, WR Cannon, KD Jarman, and KH Jarman. 2004. "Sequence optimization as an alternative to de novo analysis of tandem mass spectrometry data." Bioinformatics 20(14):2296-2304. 
  • Malard JM, A Heredia-Langner, DJ Baxter, KH Jarman, and WR Cannon. 2004. "Constrained De-Novo Peptide Identification via Multi-objective Optimization." In Proceedings of the 18th International Parallel and Distributed Processing Symposium, pp. 191-199.  Institute of Electrical and Electronics Engineers, Piscataway, NJ. 


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