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Biological Sciences Staff information


Keqi Tang

Instrument Dev & Deploy
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352


Dr. Keqi Tang is an electrospray ionization (ESI) mass spectrometry research scientist at Pacific Northwest National Laboratory (PNNL), where he develops technologies and methods for high performance hybrid mass spectrometry and its applications in chemical and biological analyses. Dr. Tang's current research advances ion mobility spectrometry (IMS) instrumentation methods for ultra-high throughput applications in system-biology studies; this research also includes developing a fundamental understanding of both conventional drift tube IMS and high field asymmetric waveform IMS through extensive theoretical modeling and experimental evaluation. Additionally, Dr. Tang is developing and implementing new ESI interfaces for high sensitivity mass spectrometry.

Dr. Tang has been a research scientist at PNNL from 2000. Prior to then, he was a research and development scientist at Thermo Finnigan LLC from 1997; a senior mechanical engineer at YSI Inc. from 1996; a postdoctoral fellow at PNNL from 1995; and a postdoctoral research associate at Yale University's Department of Mechanical Engineering from 1994.

Dr. Tang holds 27 issued U.S. patents, and is a significant contributor to his field with over 90 peer-reviewed publications and numerous invited and conference presentations.

Research Interests

  • Fundamentals of ESI and mass spectrometry applications
  • IMS and field asymmetric waveform IMS development
  • Mass spectrometric instrumentations including high-efficiency ion optics and liquid chromatography-mass spectrometry interface development for high throughput and high sensitivity ESI-mass spectrometry applications
  • Micro-fabrication technologies and their applications in micro electrospray arrays and micro fluidics
  • Biological applications of mass spectrometry including sample identification and quantification

Education and Credentials

  • Ph.D., Mechanical Engineering, Yale University
  • M.Ph., Mechanical Engineering, Yale University
  • M.S., Mechanical Engineering, Yale University
  • M.S., Thermophysics, University of Science and Technology of China
  • B.S., Mathematical Mechanics, Tsinghua University, China

Awards and Recognitions

  • 2015 R&D 100 Award for SPIN (Subambient pressure ionization with nanoelectrospray) Source
  • 2013 R&D 100 Award for Combined Orthogonal Mobility & Mass Evaluation Technology (CoMet)
  • 2013 PNNL Director's Award for Exceptional Engineering Achievement
  • 2013 FLC (Federal Laboratory Consortium) Award for Excellence in Technology Transfer
  • 2012 Distinguished Inventor of Battelle
  • 2012 FLC Award for Excellence in Technology Transfer
  • 2011 U.S. Department of Energy Outstanding Mentor Award
  • 2010 R&D 100 Award for Ion Mobility Spectrometer on a Microchip
  • 2009 R&D 100 Award for Ultrasensitive Electrospray Ionization Mass Spectrometry Source and Interface
  • 2007 PNNL Inventor of the Year
  • 2004 FLC Award for Excellence in Technology Transfer

PNNL Publications


  • Zheng X, X Zhang, N Schocker, RS Renslow, DJ Orton, J Khamsi, RA Ashmus, IC Almeida, K Tang, CE Costello, RD Smith, K Michael, and EM Baker. 2017. "Enhancing Glycan Isomer Separations with Metal Ions and Positive and Negative Polarity Ion Mobility Spectrometry-Mass Spectrometry Analyses." Analytical and Bioanalytical Chemistry 409:467-476.  doi:10.1007/s00216-016-9866-4
  • Guo X, and K Tang. 2017. "Mass Spectrometry-based Assay for High Throughput and High Sensitivity Biomarker Verification." Chapter 9 in Protein Analysis Using Mass Spectrometry: Accelerating Protein Biotherapeutics from Lab to Patient, ed. MS Lee and GC Ji.  John Willey & Sons, Inc., HOBOKEN, NJ.  doi:10.1002/9781119371779.ch9


  • Cong Y, S Katipamula, T Geng, SA Prost, K Tang, and RT Kelly. 2016. "Electrokinetic Sample Preconcentration and Hydrodynamic Sample Injection for Microchip Electrophoresis Using a Pneumatic Microvalve." Electrophoresis 37(3):455-462.  doi:10.1002/elps.201500286
  • Garimella VBS, YM Ibrahim, K Tang, IK Webb, EM Baker, AV Tolmachev, TC Chen, GA Anderson, and RD Smith. 2016. "Spatial Ion Peak Compression and its Utility in Ion Mobility Spectrometry." Journal of the American Society for Mass Spectrometry 27(6):1128-1135.  doi:10.1007/s13361-016-1371-7
  • Guo X, TL Fillmore, Y Gao, and K Tang. 2016. "Capillary Electrophoresis-nanoelectrospray Ionization-selected Reaction Monitoring Mass Spectrometry Via A True Sheathless Metal-coated Emitter Interface For Robust And High Sensitivity Sample Quantification." Analytical Chemistry 88(8):4418-4425.  doi:10.1021/acs.analchem.5b04912
  • Heyman HM, X Zhang, K Tang, ES Baker, and TO Metz. 2016. "Conventional and Advanced Separations in Mass Spectrometry-Based Metabolomics: Methodologies and Applications." In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, ed. Reedijk, J.  Elsevier, Amsterdam, , Netherlands.  doi:10.1016/B978-0-12-409547-2.12132-8
  • Li X, JT Cox, W Huang, M Kane, K Tang, and CJ Bieberich. 2016. "Quantifying Kinase-specific Phosphorylation Stoichiometry Using Stable Isotope Labeling In a Reverse In-gel Kinase Assay." Analytical Chemistry 88(23):11468-11475.  doi:10.1021/acs.analchem.6b02599


  • Chen TC, IK Webb, SA Prost, MB Harrer, RV Norheim, K Tang, YM Ibrahim, and RD Smith. 2015. "Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations." Analytical Chemistry 87(1):716-722.  doi:10.1021/ac503564c
  • Cox JT, I Marginean, RD Smith, and K Tang. 2015. "On the Ionization and Ion Transmission Efficiencies of Different ESI-MS Interfaces." Journal of the American Society for Mass Spectrometry 26(1):55-62.  doi:10.1007/s13361-014-0998-5
  • Liu TL, JT Cox, D Hu, X Deng, JZ Hu, MY Hu, J Xiao, Y Shao, K Tang, and J Liu. 2015. "A Fundamental Study on the [(µ-Cl)3Mg2(THF)6]+ Dimer Electrolytes for Rechargeable Mg Batteries." Chemical Communications 51(12):2312-2315.  doi:10.1039/c4cc07621d
  • Zhang X, VBS Garimella, SA Prost, IK Webb, TC Chen, K Tang, AV Tolmachev, RV Norheim, ES Baker, GA Anderson, YM Ibrahim, and RD Smith. 2015. "Ion Trapping, Storage, and Ejection in Structures for Lossless Ion Manipulations ." Analytical Chemistry 87(12):6010-6016.  doi:10.1021/acs.analchem.5b00214


  • Cox JT, I Marginean, RT Kelly, RD Smith, and K Tang. 2014. "Improving the Sensitivity of Mass Spectrometry by Using a New Sheath Flow Electrospray Emitter Array at Subambient Pressures ." Journal of the American Society for Mass Spectrometry 25(12):2028-37.  doi:10.1007/s13361-014-0856-5
  • Kelly RT, C Wang, SJ Rausch, CS Lee, and K Tang. 2014. "Pneumatic Microvalve-Based Hydrodynamic Sample Injection for High-Throughput, Quantitative Zone Electrophoresis in Capillaries." Analytical Chemistry 86(13):6723-6729.  doi:10.1021/ac501910p
  • Kelly RT, I Marginean, and K Tang. 2014. "Electrospray Ionization Mass Spectrometry." In Encyclopedia of Microfluidics and Nanofluidics, ed. D Li, pp. 1-8.  Springer Science+Business Media, New York, NY. 
  • Cox JT, SR Kronewitter, AK Shukla, RJ Moore, RD Smith, and K Tang. 2014. "High Sensitivity Combined with Extended Structural Coverage of Labile Compounds via Nanoelectrospray Ionization at Subambient Pressures." Analytical Chemistry 86(19):9504-9511.  doi:10.1021/ac502767y
  • Marginean I, K Tang, RD Smith, and RT Kelly. 2014. "Picoelectrospray Ionization Mass Spectrometry Using Narrow-bore Chemically Etched Emitters." Journal of the American Society for Mass Spectrometry 25(1):30-36.  doi:10.1007/s13361-013-0749-z
  • Webb IK, TC Chen, WF Danielson, III, YM Ibrahim, K Tang, GA Anderson, and RD Smith. 2014. "Implementation of Dipolar Resonant Excitation Collision Induced Dissociation with Ion Mobility/Time-of-Flight MS." Journal of the American Society for Mass Spectrometry 25(4):563-571.  doi:10.1007/s13361-013-0815-6


  • Sun X, K Tang, RD Smith, and RT Kelly. 2013. "Controlled Dispensing and Mixing of Pico- to Nanoliter Volumes Using On-Demand Droplet-Based Microfluidics." Microfluidics and Nanofluidics 15(1):117-126.  doi:10.1007/s10404-012-1133-1
  • Shi T, X Sun, Y Gao, TL Fillmore, AA Schepmoes, R Zhao, J He, RJ Moore, J Kagan, KD Rodland, T Liu, AY Liu, RD Smith, K Tang, DG Camp, II, and W Qian. 2013. "Targeted quantification of low ng/mL level proteins in human serum without immunoaffinity depletion." Journal of Proteome Research 12(7):3353-3361.  doi:10.1021/pr400178v
  • Wang CC, CS Lee, RD Smith, and K Tang. 2013. "Capillary Isotachophoresis-Nanoelectrospray Ionization-Selected Reaction Monitoring MS via a Novel Sheathless Interface for High Sensitivity Sample Quantification." Analytical Chemistry 85(15):7308-7315.  doi:10.1021/ac401202c


  • Sun X, K Tang, RD Smith, and RT Kelly. 2012. "Robust Extraction Interface for Coupling Droplet-Based and Continuous Flow Microfluidics." Chapter 7 in Advances in Microfluidics, ed. R Kelly, pp. 155-170.  InTech, Rijeka, Croatia (Local Name: Hrvatska). 
  • Gao X, Q Zhang, D Meng, G Isaac, R Zhao, TL Fillmore, RK Chu, J Zhou, K Tang, Z Hu, RJ Moore, RD Smith, MG Katze, and TO Metz. 2012. "A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling." Analytical and Bioanalytical Chemistry 402(9):2923-2933. 
  • Marginean I, SR Kronewitter, RJ Moore, GW Slysz, ME Monroe, GA Anderson, K Tang, and RD Smith. 2012. "Improving N-Glycan Coverage using HPLC-MS with Electrospray Ionization at Subambient Pressure." Analytical Chemistry 84(21):9208-9213.  doi:10.1021/ac301961u
  • Shi T, D Su, T Liu, K Tang, DG Camp, II, W Qian, and RD Smith. 2012. "Advancing the sensitivity of selected reaction monitoring-based targeted quantitative proteomics." Proteomics 12(8):1074-1092.  doi:10.1002/pmic.201100436
  • Shi T, TL Fillmore, X Sun, R Zhao, AA Schepmoes, M Hossain, F Xie, S Wu, JS Kim, NJ Jones, RJ Moore, L Pasa-Tolic, J Kagan, KD Rodland, T Liu, K Tang, DG Camp, II, RD Smith, and W Qian. 2012. "Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum." Proceedings of the National Academy of Sciences of the United States of America 109(38):15395-15400.  doi:10.1073/pnas.1204366109
  • Wang C, CS Lee, RD Smith, and K Tang. 2012. "Ultrasensitive Sample Quantitation via Selected Reaction Monitoring Using CITP/CZE-ESI-Triple Quadrupole MS." Analytical Chemistry 84(23):10395-10403.  doi:10.1021/ac302616m


  • Hossain M, DT Kaleta, EW Robinson, T Liu, R Zhao, JS Page, RT Kelly, RJ Moore, K Tang, DG Camp, II, W Qian, and RD Smith. 2011. "Enhanced Sensitivity for Selected Reaction Monitoring–Mass Spectrometry-based Targeted Proteomics using a Dual-Stage Electrodynamic Ion Funnel Interface ." Molecular & Cellular Proteomics. MCP 10(2):, doi:10.1074/mcp.M000062-MCP201
  • Sun X, RT Kelly, K Tang, and RD Smith. 2011. "Membrane-Based Emitter for Coupling Microfluidics with Ultrasensitive Nanoelectrospray Ionization-Mass Spectrometry." Analytical Chemistry 83(4):5797-5803.  doi:10.1021/ac200960h
  • Johnson PV, R Hodyss, K Tang, W Brinckerhoff, and RD Smith. 2011. "The Laser Ablation Ion Funnel: Sampling for In Situ Mass Spectrometry on Mars." Planetary and Space Science 59(5-6):387-393.  doi:10.1016/j.pss.2011.01.004
  • Sun X, RT Kelly, WF Danielson, III, N Agrawal, K Tang, and RD Smith. 2011. "Hydrodynamic injection with pneumatic valving for microchip electrophoresis with total analyte utilization." Electrophoresis 32(13):1610-1618.  doi:10.1002/elps.201000522
  • Tang K, JS Page, I Marginean, RT Kelly, and RD Smith. 2011. "Improving liquid chromatography-mass spectrometry sensitivity using a subambient pressure ionization with nanoelectrospray (SPIN) interface." Journal of the American Society for Mass Spectrometry 22(8):1318-1325.  doi:10.1007/s13361-011-0135-7


  • Shvartsburg AA, DC Prior, K Tang, and RD Smith. 2010. "High-Resolution Differential Ion Mobility Separations Using Planar Analyzers at Elevated Dispersion Fields." Analytical Chemistry 82(18):7649-7655.  doi:10.1021/ac101413k
  • Shvartsburg AA, K Tang, and RD Smith. 2010. "Differential Ion Mobility Separations of Peptides with Resolving Power Exceeding 50." Analytical Chemistry 82(1):32-35.  doi:10.1021/ac902133n
  • Sun X, RT Kelly, K Tang, and RD Smith. 2010. "Ultrasensitive Nanoelectrospray Ionization-Mass Spectrometry using Poly(dimethylsiloxane) Microchips with Monolithically Integrated Emitters." Analyst 135(9):2296-2302. 
  • Baker ES, EA Livesay, DJ Orton, RJ Moore, WF Danielson, DC Prior, YM Ibrahim, BL Lamarche, AM Mayampurath, AA Schepmoes, DF Hopkins, K Tang, RD Smith, and ME Belov. 2010. "An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies." Journal of Proteome Research 9(2):997-1006.  doi:10.1021/pr900888b
  • Kelly RT, AV Tolmachev, JS Page, K Tang, and RD Smith. 2010. "The Ion Funnel: Theory, Implementations and Applications." Mass Spectrometry Reviews 29(2):294-312.  doi:10.1002/mas.20232
  • Marginean I, JS Page, AV Tolmachev, K Tang, and RD Smith. 2010. "Achieving 50% ionization efficiency in sub-ambient pressure ionization with nanoelectrospray." Analytical Chemistry 82(22):9344-9349. 
  • Tang K, JS Page, RT Kelly, and I Marginean. 2010. "Electrospray Ionization in Mass Spectrometry." In Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition, vol. 1, ed. J Lindon, GE Tranter and DW Koppenaal, pp. 467-474.  Elsevier, Amsterdam, Netherlands. 


  • Page JS, I Marginean, ES Baker, RT Kelly, K Tang, and RD Smith. 2009. "Biases in Ion Transmission Through an Electrospray Ionization-Mass Spectrometry Capillary Inlet." Journal of the American Society for Mass Spectrometry 20(12):2265-2272.  doi:10.1016/j.jasms.2009.08.018
  • Prasad S, K Tang, D Manura, D Papanastasiou, and RD Smith. 2009. "Simulation of Ion Motion in FAIMS through Combined Use of SIMION and Modified SDS." Analytical Chemistry 81(21):8749-8757.  doi:10.1021/ac900880v
  • Shvartsburg AA, K Tang, RD Smith, M Holden, M Rush, A Thompson, and D Toutoungi. 2009. "Ultrafast Differential Ion Mobility Spectrometry at Extreme Electric Fields Coupled to Mass Spectrometry." Analytical Chemistry 81(19):8048-8053.  doi:10.1021/ac901479e
  • Kelly RT, JS Page, I Marginean, K Tang, and RD Smith. 2009. "Dilution-Free Analysis from Picoliter Droplets by Nano-Electrospray Ionization Mass Spectrometry." Angewandte Chemie International Edition 48(37):6832-6835.  doi:10.1002/anie.200902501
  • Mabrouki RB, RT Kelly, DC Prior, AA Shvartsburg, K Tang, and RD Smith. 2009. "Improving FAIMS Sensitivity using a Planar Geometry with Slit Interfaces." Journal of the American Society for Mass Spectrometry 20(9):1768-1774.  doi:10.1016/j.jasms.2009.05.019
  • Marginean I, JS Page, RT Kelly, K Tang, and RD Smith. 2009. "Effect of pressure on electrospray characteristics." Applied Physics Letters 95(18):Article Number: 184103 . 
  • Marginean I, RT Kelly, RJ Moore, DC Prior, BL Lamarche, K Tang, and RD Smith. 2009. "Selection of the Optimum Electrospray Voltage for Gradient Elution LC-MS Measurements." Journal of the American Society for Mass Spectrometry 20(4):682-688. 
  • Yang F, S Wu, DL Stenoien, R Zhao, ME Monroe, MA Gritsenko, SO Purvine, AD Polpitiya, N Tolic, Q Zhang, AD Norbeck, DJ Orton, RJ Moore, K Tang, GA Anderson, L Pasa-Tolic, DG Camp, II, and RD Smith. 2009. "Combined Pulsed-Q dissociation and electron transfer dissociation for identification and quantitation of iTRAQ–labeled phosphopeptides." Analytical Chemistry 81(10):4137-4143.  doi:10.1021/ac802605m


  • Kelly RT, K Tang, D Irimia, M Toner, and RD Smith. 2008. "Elastomeric Microchip Electrospray Emitter for Stable Cone-Jet Mode Operation in the Nanoflow Regime." Analytical Chemistry 80(10):3824-3831. 
  • Metz TO, JS Page, ES Baker, K Tang, J Ding, Y Shen, and RD Smith. 2008. "High Resolution Separations and Improved Ion Production and Transmission in Metabolomics." Trends in Analytical Chemistry. TrAC 27(3):205-214.  doi:10.1016/j.trac.2007.11.003
  • Page JS, K Tang, RT Kelly, and RD Smith. 2008. "Subambient pressure ionization with nanoelectrospray source and interface for improved sensitivity in mass spectrometry ." Analytical Chemistry Vol. 80(5):1800-1805.  doi:10.1021/ac702354b
  • Shvartsburg AA, K Tang, and RD Smith. 2008. "Two-Dimensional Ion Mobility Analyses of Proteins and Peptides." Chapter 26 in Mass Spectrometry of Proteins and Peptides: Methods and Protocols, Methods in Molecular Biology, vol. 492, ed. MS Lipton and L Pasa-Tolic, pp. 417-445.  Humana Press, Totowa, NJ. 
  • Page JS, K Tang, RT Kelly, and RD Smith. 2008. "A subambient pressure ionization with nanoelectrospray (SPIN) source and interface for improved sensitivity in mass spectrometry." Analytical Chemistry 80(5):1800-1805.  doi:10.1021/ac702354b
  • Baker ES, K Tang, WF Danielson, III, DC Prior, and RD Smith. 2008. "Simultaneous Fragmentation of Multiple Ions Using IMS Drift Time Dependent Collision Energies." Journal of the American Society for Mass Spectrometry 19(3):411-419.  doi:10.1016/j.jasms.2007.11.018
  • Kelly RT, JS Page, I Marginean, K Tang, and RD Smith. 2008. "Nanoelectrospray Emitter Arrays Providing Interemitter Electric Field Uniformity." Analytical Chemistry 80(14):5660-5665.  doi:10.1021/ac800508q
  • Kelly RT, JS Page, R Zhao, W Qian, HM Mottaz, K Tang, and RD Smith. 2008. "Capillary-Based Multi Nanoelectrospray Emitters: Improvements in Ion Transmission Efficiency and Implementation with Capillary Reversed-Phase LC-ESI-MS." Analytical Chemistry 80(1):143-149.  doi:10.1021/ac701647s
  • Livesay EA, K Tang, BK Taylor, MA Buschbach, DF Hopkins, BL Lamarche, R Zhao, Y Shen, DJ Orton, RJ Moore, RT Kelly, HR Udseth, and RD Smith. 2008. "Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses." Analytical Chemistry 80(1):294-302.  doi:10.1021/ac701727r
  • Marginean I, RT Kelly, DC Prior, BL Lamarche, K Tang, and RD Smith. 2008. "Analytical Characterization of the Electrospray Ion Source in the Nanoflow Regime." Analytical Chemistry 80(17):6573-6579.  doi:10.1021/ac800683s
  • Petyuk VA, N Jaitly, RJ Moore, J Ding, TO Metz, K Tang, ME Monroe, AV Tolmachev, JN Adkins, ME Belov, AR Dabney, W Qian, DG Camp, II, and RD Smith. 2008. "Elimination of Systematic Mass Measurement Errors in Liquid Chromatography-Mass Spectrometry Based Proteomics using Regression Models and a priori Partial Knowledge of the Sample Content ." Analytical Chemistry 80(3):693-706.  doi:10.1021/ac701863d
  • Robinson EW, AA Shvartsburg, K Tang, and RD Smith. 2008. "Control of Ion Distortion in Field Asymmetric Waveform Ion Mobility Spectrometry via Variation of Dispersion Field and Gas Temperature ." Analytical Chemistry 80(19):7508-7515.  doi:10.1021/ac800655d


  • Page JS, K Tang, and RD Smith. 2007. "An electrodynamic ion funnel interface for greater sensitivity and higher throughput with linear ion trap mass spectrometers." International Journal of Mass Spectrometry 265(2-3):244-250.  doi:10.1016/j.ijms.2007.02.032
  • Page JS, RT Kelly, K Tang, and RD Smith. 2007. "Ionization and transmission efficiency in an electrospray ionization-mass spectrometry interface." Journal of the American Society for Mass Spectrometry 18(9):1582-1590.  doi:10.1016/j.jasms.2007.05.018
  • Shvartsburg AA, F Li, K Tang, and RD Smith. 2007. "Distortion of Ion Structures by Field Asymmetric Waveform Ion Mobility Spectrometry." Analytical Chemistry 79(4):1523-1528.  doi:10.1021/ac061306c
  • Baker ES, BH Clowers, F Li, K Tang, AV Tolmachev, DC Prior, ME Belov, and RD Smith. 2007. "Ion Mobility Spectrometry – Mass Spectrometry Performance Using Electrodynamic Ion Funnels and Elevated Drift Gas Pressures." Journal of the American Society for Mass Spectrometry 18(7):1176-1187.  doi:doi:10.1016/j.jasms.2007.03.031
  • Belov ME, MA Buschbach, DC Prior, K Tang, and RD Smith. 2007. "Multiplexed Ion Mobility Spectrometry - Orthogonal Time-Of-Flight Mass Spectrometry ." Analytical Chemistry 79(6):2451-2462.  doi:10.1021/ac0617316
  • Kelly RT, JS Page, K Tang, and RD Smith. 2007. "Array of Chemically Etched Fused Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry." Analytical Chemistry 79(11):4192-4198.  doi:10.1021/ac062417e
  • Luo Q, JS Page, K Tang, and RD Smith. 2007. "MicroSPE-nanoLC-ESI-MS/MS using 10-µm-i.d. silica-based monolithic columns for proteomics." Analytical Chemistry 79(2):540-545. 
  • Marginean N, RT Kelly, JS Page, K Tang, and RD Smith. 2007. "Electrospray characteristic curves: in pursuit of improved performance in the nano-flow regime." Analytical Chemistry 79(21):8030-8036.  doi:10.1021/ac070800t


  • Page JS, AV Tolmachev, K Tang, and RD Smith. 2006. "Theoretical and experimental evaluation of the low m/z transmission of an electrodynamic ion funnel." Journal of the American Society for Mass Spectrometry 17(4):586-592. 
  • Shvartsburg AA, F Li, K Tang, and RD Smith. 2006. "Characterizing the Structures and Folding of Free Proteins Using 2-D Gas-Phase Separations: Observation of Multiple Unfolded Conformers." Analytical Chemistry 78(10):3304-3315.  doi:10.1021/ac060283z
  • Shvartsburg AA, F Li, K Tang, and RD Smith. 2006. "High-Resolution Field Asymmetric Waveform Ion Mobility Spectrometry Using New Planar Geometry Analyzers." Analytical Chemistry 78(11):3706-3714.  doi:10.1021/ac052020v
  • Shvartsburg AA, T Bryskiewicz, R Purves, K Tang, R Guevremont, and RD Smith. 2006. "Field Asymmetric Waveform Ion Mobility Spectrometry Studies of Proteins: Dipole Alignment in Ion Mobility Spectrometry?" Journal of Physical Chemistry B 110(43):21966-21980.  doi:10.1021/jp062573p
  • Ibrahim YM, K Tang, AV Tolmachev, AA Shvartsburg, and RD Smith. 2006. "Improving Mass Spectrometer Sensitivity Using a High-Pressure Electrodynamic Ion Funnel Interface." Journal of the American Society for Mass Spectrometry 17(9):1299-1305.  doi:10.1016/j.jasms.2006.06.005
  • Kelly RT, JS Page, Q Luo, RJ Moore, DJ Orton, K Tang, and RD Smith. 2006. "Chemically Etched Open Tubular and Monolithic Emitters for Nanoelectrospray Ionization Mass Spectrometry." Analytical Chemistry 78(22):7796-7801. 
  • Luo Q, K Tang, F Yang, A Elias, Y Shen, RJ Moore, R Zhao, KK Hixson, SS Rossie, and RD Smith. 2006. "More sensitive and quantitative proteomic measurements using very low flow rate porous silica monolithic LC columns with electrospray ionization-mass spectrometry ." Journal of Proteome Research 5(5):1091-1097. 
  • Smith RD, K Tang, and Y Shen. 2006. "Ultra-sensitive and quantitative characterization of proteomes." Molecular Biosystems 2(5):221-230.  doi:10.1039/b601468b
  • Yang F, DL Stenoien, EF Strittmatter, JH Wang, L Ding, MS Lipton, ME Monroe, CD Nicora, MA Gritsenko, K Tang, R Fang, JN Adkins, DG Camp, II, DJ Chen, and RD Smith. 2006. "Phosphoproteome Profiling of Human Skin Fibroplast Cells in Response to Low- and High-Dose Irradiation ." Journal of Proteome Research 5(5):1252-1260. 


  • Page JS, AV Tolmachev, K Tang, and RD Smith. 2005. "Variable low-mass filtering using an electrodynamic ion funnel." Journal of Mass Spectrometry 40(9):1215-1222.  doi:10.1002/jms.900
  • Page JS, B Bogdanov, AN Vilkov, DC Prior, MA Buschbach, K Tang, and RD Smith. 2005. "Automatic Gain Control in Mass Spectrometry using a Jet Disrupter Electrode in an Electrodynamic Ion Funnel." Journal of the American Society for Mass Spectrometry 16(2):244-253. 
  • Shvartsburg AA, K Tang, and RD Smith. 2005. "FAIMS Operation for Realistic Gas Flow Profile and Asymmetric Waveforms Including Electronic Noise and Ripple." Journal of the American Society for Mass Spectrometry 16(9):1447-1455.  doi:10.1016/j.jasms.2005.04.003
  • Shvartsburg AA, K Tang, and RD Smith. 2005. "Optimization of the Design and Operation of FAIMS Analyzers." Journal of the American Society for Mass Spectrometry 16(1):2-12. 
  • Tang K, AA Shvartsburg, HN Lee, DC Prior, MA Buschbach, F Li, AV Tolmachev, GA Anderson, and RD Smith. 2005. "High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces ." Analytical Chemistry 77(10):3330-3339.  doi:10.1021/ac048315a
  • Tang K, F Li, AA Shvartsburg, EF Strittmatter, and RD Smith. 2005. "Two-Dimensional Gas-Phase Separations Coupled to Mass Spectrometry for Analysis of Complex Mixtures." Analytical Chemistry 77(19):6381-6388. 


  • Shvartsburg AA, K Tang, and RD Smith. 2004. "Modeling the Resolution and Sensitivity of FAIMS analyses." Journal of the American Society for Mass Spectrometry 15(10):1487-98. 
  • Shvartsburg AA, K Tang, and RD Smith. 2004. "Understanding and Designing Field Asymmetric Waveform Ion Mobility Spectrometry Separations in Gas Mixtures." Analytical Chemistry 76(24):7366-7374.  doi:10.1021/ac049299k
  • Belov ME, GA Anderson, MA Wingerd, HR Udseth, K Tang, DC Prior, KR Swanson, MA Buschbach, EF Strittmatter, RJ Moore, and RD Smith. 2004. "An Automated High Performance Capillary Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for High-Throughput Proteomics." Journal of the American Society for Mass Spectrometry 15(2):212-232. 
  • Smith RD, Y Shen, and K Tang. 2004. "Ultra-sensitive and quantitative analyses from combined separations-mass spectrometry for the characterization of proteomes." Accounts of Chemical Research 37(4):269-278. 
  • Tang K, JS Page, and RD Smith. 2004. "Charge Competition and the Linear Dynamic Range of Detection in Electrospray Ionization Mass Spectrometry." Journal of the American Society for Mass Spectrometry 15(10):1416-1423. 


  • Belov ME, R Zhang, EF Strittmatter, DC Prior, K Tang, and RD Smith. 2003. "Automated Gain Control and Internal Calibration With External Ion Accumulation Capillary liquid chromatography-electrospray ionization-fourier transform ion cyclotron resonance." Analytical Chemistry 75(16):4195-4205. 
  • Qian W, MB Goshe, DG Camp, II, LR Yu, K Tang, and RD Smith. 2003. "Phosphoprotein Isotope-Coded Solid-Phase Tag Approach for Enrichment and Quantitative Analysis of Phosphopeptides from Complex Mixtures." Analytical Chemistry 75(20):5441-5450. 
  • Strittmatter EF, PL Ferguson, K Tang, and RD Smith. 2003. "Proteome Analyses Using Accurate Mass and Elution Time Peptide Tags with Capillary LC Time-of-Flight Mass Spectrometry." Journal of the American Society for Mass Spectrometry 14(9):980-991. 


  • Lin Y, K Tang, and RD Smith. 2002. "Laser-Machined Microdevices for Mass Spectrometry." Chapter 6 in Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research, ed. J. Silberring and R. Ekman, pp. 171-192.  John Wiley & Sons, Wiley Interscience, NY. 
  • Tang K, AV Tolmachev, EN Nikolaev, R Zhang, ME Belov, HR Udseth, and RD Smith. 2002. "Independent Control of Ion Transmission in a Jet Disrupter Dual-Channel Ion Funnel Electrospray Ionization MS Interface." Analytical Chemistry 74(20):5431-5437. 


  • Tang K, and RD Smith. 2001. "Physical/Chemical Separations in the Break-up of Highly Charged Droplets from Electrosprays." Journal of the American Society for Mass Spectrometry 12(3):343-347. 
  • Tang K, and RD Smith. 2001. "Sensitivity Enhancement of Electrospray Ionization MS for Aqueous Solutions in the Corona-Assisted Cone-Jet Mode." International Journal of Mass Spectrometry and Ion Processes 162(1-3):69-76. 
  • Tang K, Y Lin, DW Matson, TM Kim, and RD Smith. 2001. "Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity." Analytical Chemistry 73(8):1658-1663. 
  • Kim TM, K Tang, HR Udseth, and RD Smith. 2001. "A Multi-capillary Inlet Jet Disruption Electrodynamic Ion Funnel Interface for Improved Sensitivity Using Atmospheric Pressure Ion Sources." Analytical Chemistry 73(17):4162-4170. 
  • Shen Y, R Zhao, ME Belov, TP Conrads, GA Anderson, K Tang, L Pasa-Tolic, TD Veenstra, MS Lipton, HR Udseth, and RD Smith. 2001. "Packed Capillary Reversed-Phase Liquid Chromatography with High Performance Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Proteomics ." Analytical Chemistry 73(8):1766-1775. 


  • Tang K, and RD Smith. 1999. "Theoretical Prediction of Charged Droplet Evaporation and Fission in Electrospray Ionization." International Journal of Mass Spectrometry 185/186/187:97-105. 

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