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Biological Sciences Staff information

Richard Smith

Richard Smith

Biological Sciences Division
Battelle Fellow
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352


Dr. Smith's research interests span development of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research. Over the last 20 years, much of Dr. Smith's research has centered on creating and applying new ultra-sensitive technologies to quantitatively probe entire proteomes expressed by cells, tissues, and organisms. In the last decade, these efforts have broadened to include development and application of highly sensitive, high-throughput technologies for measuring the "pan-ome" (the array of biomolecule measurements that include the proteome, metabolome, lipidome, and glycome) to augment biological research. To enable much more effective pan-omics applications, he has recently been leading the development of novel Structures for Lossless Ion Manipulations (SLIM) and their use for very-high-throughput sample processing, reactions, separations, and other manipulations of ions in the gas phase, and particularly in conjunction with mass spectrometry.

Dr. Smith also is Director of Proteome Research at PNNL, Director of the NIH Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member in the Department of Chemistry at the University of Idaho and the Department of Molecular Microbiology & Immunology at Oregon Health & Science University. Dr. Smith completed his Ph.D. work in Physical Chemistry at the University of Utah.

Dr. Smith is the author/co-author of more than 1000 peer-reviewed journal articles and is the recipient of 55 patents and 10 R&D 100 Awards.

Research Interests

  • Development and application of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research
  • Development and application of new ultra-sensitive methods for quantitatively probing the entire array of proteins expressed by a cell, tissue or organism, i.e., their "proteomes"
  • Increasing the throughput and sensitivity of proteomics, metabolomics, and other pan-omics measurements to augment systems biology research

Education and Credentials

  • B.S., Chemistry, Lowell Technological Institute, University of Massachusetts
  • Ph.D., Physical Chemistry, University of Utah

Affiliations and Professional Service

  • American Chemical Society
  • American Society for Mass Spectrometry
  • American Association for the Advancement of Science (Fellow)
  • Adjunct Professor, Department of Chemistry, Washington State University
  • Affiliate Professor, Department of Chemistry, University of Idaho
  • Adjunct Professor of Chemistry, University of Utah
  • Affiliate Professor, Department of Molecular Microbiology & Immunology, Oregon Health & Science University

Awards and Recognitions

  • American Society for Mass Spectrometry Distinguished Contribution in Mass Spectrometry Award (2013)
  • R&D Magazine 2010 Scientist of the Year
  • Ten R&D 100 Awards:
    • Combined Orthogonal Mobility & Mass Evaluation Technology (2013)
    • Ion Mobility Spectrometer on a Microchip (2010)
    • Ultrasensitive Electrospray Ionization Mass Spectrometry Source and Interface (2009)
    • Development of the FT-MS Proteome Express (2003)
    • Electrodynamic Ion Funnel (1999)
    • Rapid Microdialyzer (1998)
    • MICLEAN/MICARE Process (1998)
    • Rapid Expansion of Supercritical Fluid Solutions Process (1988)
    • Capillary Electrophoresis-Electrospray Ionization-MS (1988). Named among top 40 R&D 100 Awards of all time.
    • Development of Supercritical Fluid Chromatography-MS (1983)
  • Federal Laboratory Consortium Award for the Electrodynamic Ion Funnel (2004)
  • Elected Fellow, American Association for the Advancement of Science (2007)
  • Wiley Research Fellow, Environmental Molecular Sciences Laboratory
  • Eastern Analytical Symposium Award for Outstanding Achievements in the Fields of Analytical Chemistry (2010)
  • Elected to Washington State Academy of Sciences
  • Gordon Battelle Prize for Scientific Discovery
  • HUPO Discovery Award in Proteomic Sciences (2009)
  • Council of the Human Proteome Organization (HUPO) 2007-2016
  • Scientific American 50--shared with Dr. Desmond Smith, University of California at Los Angeles, for their work on understanding the human brain (2007)
  • 2003 ACS Award for Analytical Chemistry
  • American Oil Chemists Society Award
  • Battelle-Northwest Director's Award for Excellence
  • AWU-DOE Distinguished Lecturer
  • Battelle Inventor of the Year
  • Pacific Northwest National Laboratory Mentor of the Year
  • DOE Energy 100 Award
  • ACS Award for Analytical Chemistry
  • ICI List of most cited chemists
  • Serves on nine scientific journal advisory boards

PNNL Publications



  • Depuydt GG, F Xie, VA Petyuk, A Smolders, HM Brewer, DG Camp, II, RD Smith, and BP Braeckman. 2014. "LC-MS Proteomics Analysis of the Insulin/IGF-1 Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism." Journal of Proteome Research 13(4):1938-1956.  doi:10.1021/pr401081b



  • Wiedner SD, KE Burnum, LM Pederson, LN Anderson, S Fortuin, LM Chauvigne-Hines, AK Shukla, C Ansong, EA Panisko, RD Smith, and AT Wright. 2012. "Multiplexed Activity-Based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes Upon Exposure to Human Serum." Journal of Biological Chemistry 287(40):33447-33459.  doi:10.1074/jbc.M112.394106




  • Kim BC, D Lopez-Ferrer, S Lee, H Ahn, S Nair, S Kim, BS Kim, K Petritis, DG Camp, II, JW Grate, RD Smith, Y Koo, MB Gu, and J Kim. 2009. "Highly stable trypsin-aggregate coatings on polymer nanofibers for repeated protein digestion." Proteomics 9(7):1893-900. 








  • Ramelot TA, JR Cort, A Yee, F Liu, MB Goshe, AM Edwards, RD Smith, CH Arrowsmith, TE Dever, and MA Kennedy. 2002. "Myxoma Virus Immunomodulatory Protein M156R is a Structural Mimic of Eukaryotic Translation Initiation Factor eIF2[alpha]." Journal of Molecular Biology 322(5):943-954. 





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