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Biological Sciences Staff information

Baowei Chen

Biochemistry & Structural Biology
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352

PNNL Publications


  • Lei C, B Chen, X Li, WN Qi, and J Liu. 2013. "Non-destructively shattered mesoporous silica for protein drug delivery." Microporous and Mesoporous Materials 175:157-160.  doi:10.1016/j.micromeso.2013.03.022
  • Wei X, Z Nie, Q Luo, B Li, B Chen, KL Simmons, VL Sprenkle, and W Wang. 2013. "Nanoporous Polytetrafluoroethylene/Silica Composite Separator as a High-Performance All-Vanadium Redox Flow Battery Membrane." Advanced Energy Materials 3(9):1215-1220.  doi:10.1002/aenm.201201112
  • Fu N, D Su, JR Cort, B Chen, Y Xiong, W Qian, A Konopka, DJ Bigelow, and TC Squier. 2013. "Synthesis and Application of an Environmentally Insensitive Cy3-Based Arsenical Fluorescent Probe to Identify Adaptive Microbial Responses Involving Proximal Dithiol Oxidation." Journal of the American Chemical Society 135(9):3567-3575.  doi:10.1021/ja3117284
  • Li B, L Li, W Wang, Z Nie, B Chen, X Wei, Q Luo, Z Yang, and VL Sprenkle. 2013. "Fe/V Redox Flow Battery Electrolyte Investigation and Optimization." Journal of Power Sources 229:1-5.  doi:10.1016/j.jpowsour.2012.11.119
  • Luo Q, L Li, W Wang, Z Nie, X Wei, B Li, B Chen, Z Yang, and VL Sprenkle. 2013. "Capacity Decay and Remediation of Nafion-based All-Vanadium Redox Flow Batteries." ChemSusChem 6(2):268-274.  doi:10.1002/cssc.201200730
  • Su D, AK Shukla, B Chen, JS Kim, ES Nakayasu, Y Qu, UK Aryal, KK Weitz, TRW Clauss, ME Monroe, DG Camp, II, DJ Bigelow, RD Smith, RN Kulkarni, and W Qian. 2013. "Quantitative Site-specific Reactivity Profiling of S-Nitrosylation in Mouse Skeletal Muscle Using Cysteinyl Peptide Enrichment Coupled with Mass Spectrometry." Free Radical Biology & Medicine 57:68-78.  doi:10.1016/j.freeradbiomed.2012.12.010


  • Tam TK, B Chen, C Lei, and J Liu. 2012. "In situ Regeneration of NADH via Lipoamide Dehydrogenase-catalyzed Electron Transfer Reaction Evidenced by Spectroelectrochemistry." Bioelectrochemistry and Bioenergetics 86:92-96.  doi:10.1016/j.bioelechem.2012.03.002
  • Luo Q, L Li, Z Nie, W Wang, X Wei, B Li, B Chen, and Z Yang. 2012. "In-situ Investigation of Vanadium Ion Transport in Redox Flow Battery." Journal of Power Sources 218(1):15-20.  doi:10.1016/j.jpowsour.2012.06.066
  • Wang W, L Li, Z Nie, B Chen, Q Luo, Y Shao, X Wei, F Chen, G Xia, and Z Yang. 2012. "A New Hybrid Redox Flow Battery with Multiple Redox Couples." Journal of Power Sources 216:99-103.  doi:10.1016/j.jpowsour.2012.05.032
  • Wang W, Z Nie, B Chen, F Chen, Q Luo, X Wei, G Xia, M Skyllas-Kazacos, L Li, and Z Yang. 2012. "A New Fe/V Redox Flow Battery Using Sulfuric/Chloric Mixed Acid Supporting Electrolyte." Advanced Energy Materials 2(4):487-493.  doi:10.1002/aenm.201100527
  • Wen Q, X Li, B Chen, P Yao, C Lei, and J Liu. 2012. "Intramesoporous Silica Structure Differentiating Protein Loading Density." Materials Letters 75:102-106.  doi:10.1016/j.matlet.2012.01.128
  • Yu Y, B Chen, WN Qi, X Li, Y Shin, C Lei, and J Liu. 2012. "Enzymatic Conversion of CO2 to Bicarbonate in Functionalized Mesoporous Silica." Microporous and Mesoporous Materials 153:166-170.  doi:10.1016/j.micromeso.2011.12.005


  • Xiong Y, B Chen, L Shi, JK Fredrickson, DJ Bigelow, and TC Squier. 2011. "Targeted Protein Degradation of Outer Membrane Decaheme Cytochrome MtrC Metal Reductase in Shewanella oneidensis MR-1 Measured Using Biarsenical Probe CrAsH-EDT2." Biochemistry 50(45):9738-9751.  doi:10.1021/bi200602f
  • Chen B, SS Shah, Y Shin, C Lei, and J Liu. 2011. "In vitro release of organophosphorus acid anhydrolase from functionalized mesoporous silica against nerve agents." Analytical Biochemistry 421(2):477-81.  doi:10.1016/j.ab.2011.09.024
  • Li L, S Kim, W Wang, M Vijayakumar, Z Nie, B Chen, J Zhang, G Xia, JZ Hu, GL Graff, J Liu, and Z Yang. 2011. "A Stable Vanadium Redox-Flow Battery with High Energy Density for Large-scale Energy Storage." Advanced Energy Materials 1(3):394-400. 
  • Wang W, S Kim, B Chen, Z Nie, J Zhang, G Xia, L Li, and Z Yang. 2011. "A New Redox Flow Battery Using Fe/V Redox Couples in Chloride Supporting Electrolyte." Energy & Environmental Science 4(10):4068-4073.  doi:10.1039/C0EE00765J
  • Zhang J, L Li, Z Nie, B Chen, M Vijayakumar, S Kim, W Wang, B Schwenzer, J Liu, and Z Yang. 2011. "Effects of additives on the stability of electrolytes for all-vanadium redox flow batteries." Journal of Applied Electrochemistry 41(10 - Special Issue S1):1215-1221.  doi:10.1007/s10800-011-0312-1


  • Lei C, P Liu, B Chen, Y Mao, HE Engelmann, Y Shin, J Jaffar, I Hellstrom, J Liu, and KE Hellstrom. 2010. "Local Release of Highly Loaded Antibodies from Functionalized Nanoporous Support for Cancer Immunotherapy." Journal of the American Chemical Society 132(20):6906-6907. 
  • Zhang X, ME Monroe, B Chen, MH Chin, TH Heibeck, AA Schepmoes, F Yang, BO Petritis, DG Camp, II, JG Pounds, JM Jacobs, DJ Smith, DJ Bigelow, RD Smith, and W Qian. 2010. "Endogenous 3, 4- Dihydroxyphenylalanine and Dopaquinone Modifications on Protein Tyrosine: links to mitochondrially derived oxidative stress via hydroxyl radical." Molecular & Cellular Proteomics. MCP 9(6):1199-1208. 


  • Chen B, C Lei, Y Shin, and J Liu. 2009. "Probing Mechanisms for Enzymatic Activity Enhancement of Organophosphorus Hydrolase in Functionalized Mesoporous Silica." Biochemical and Biophysical Research Communications 390(4):1177-1181.  doi:10.1016/j.bbrc.2009.10.112


  • Chen B, D Lowry, MU Mayer, and TC Squier. 2008. "Helix A Stabilization Precedes Amino-terminal Lobe Activation upon Calcium Binding to Calmodulin." Biochemistry 47(35):9220-9226. 
  • Chen B, JE Mahaney, MU Mayer, DJ Bigelow, and TC Squier. 2008. "Concerted but Noncooperative Activation of Nucleotide and Actuator Domains of the Ca-ATPase Upon Calcium Binding." Biochemistry 47(47):12448-12456.  doi:10.1021/bi8014289
  • Lee AC, Z Dai, B Chen, H Wu, J Wang, A Zhang, L Zhang, TM Lim, and Y Lin. 2008. "Electrochemical Branched-DNA Assay for Polymerase Chain Reaction-Free Detection and Quantification of Oncogenes in Messenger RNA." Analytical Chemistry 80(24):9402-9410.  doi:10.1021/ac801263r


  • Cao H, Y Xiong, T Wang, B Chen, TC Squier, and MU Mayer. 2007. "A Red Cy3-Based Biarsenical Fluorescent Probe Targeted to a Complementary Binding Peptide." Journal of the American Chemical Society 129(28):8672-8673.  doi:10.1021/ja070003c
  • Cao H, Y Xiong, T Wang, B Chen, TC Squier, and MU Mayer. 2007. "A Red Cy3-Based Biarsenical Fluorescent Probe Targeted to a Complementary Binding Peptide." Journal of the American Chemical Society 129:8672-73.  doi:10.1021/ja070003c
  • Chen B, H Cao, P Yan, MU Mayer, and TC Squier. 2007. "Identification of an Orthogonal Peptide Binding Motif for Biarsenical Multiuse Affinity Probes ." Bioconjugate Chemistry 18(4):1259-1265.  doi:10.1021/bc0603900
  • Chen B, LM Markillie, Y Xiong, MU Mayer, and TC Squier. 2007. "Increased Catalytic Efficiency Following Gene Fusion of Bifunctional Methionine Sulfoxide Reductase Enzymes from Shewanella oneidensis." Biochemistry 46(49):14153-14161.  doi:10.1021/bi701151t


  • Cao H, B Chen, TC Squier, and MU Mayer. 2006. "CrAsH: A Biarsenical Multi-use Affinity Probe with low non-specific fluorescence." Chemical Communications (24):2601-2603.  doi:10.1039/b602699k
  • Xiong Y, B Chen, HS Smallwood, RJ Urbauer, LM Markillie, NA Galeva, TD Williams, and TC Squier. 2006. " High-Affinity and Cooperative Binding of Oxidized Calmodulin by Methionine Sulfoxide Reductase." Biochemistry 45(49):14642-14654.  doi:10.1021/bi0612465
  • Shi L, B Chen, Z Wang, DA Elias, MU Mayer, YA Gorby, S Ni, BH Lower, DW Kennedy, DS Wunschel, HM Mottaz, MJ Marshall, EA Hill, AS Beliaev, JM Zachara, JK Fredrickson, and TC Squier. 2006. "Isolation of a High-Affinity Functional Protein Complex between OmcA and MtrC: Two Outer Membrane Decaheme c-type Cytochromes of Shewanella oneidensis MR-1 ." Journal of Bacteriology 188(13):4705-4714.  doi:10.1128/JB.01966-05
  • Xiong Y, L Shi, B Chen, MU Mayer, BH Lower, londer, S Bose, MF Hochella, JM Zachara, JK Fredrickson, and TC Squier. 2006. "High-Affinity Binding and Direct Electron Transfer to Solid Metals by the Shewanella oneidensis MR-1 Outer Membrane c-type Cytochrome OmcA." Journal of the American Chemical Society 128(43):13978-13979.  doi:10.1021/ja063526d
  • Yan P, Y Xiong, B Chen, S Negash, TC Squier, and MU Mayer. 2006. "Fluorophore-Assisted Light Inactivation of Calmodulin Involves Singlet-Oxygen Mediated Cross-Linking and Methionine Oxidation." Biochemistry 45(15):4736-4748.  doi:10.1021/bi052395a


  • Chen B, MU Mayer, and TC Squier. 2005. "Structural Uncoupling between Opposing Domains of Oxidized Calmodulin Underlies the Enhanced Binding Affinity and Inhibition of the Plasma Membrane Ca-ATPase." Biochemistry 44(12):4737-4747.  doi:10.1021/bi0474113
  • Chen B, MU Mayer, LM Markillie, DL Stenoien, and TC Squier. 2005. "Dynamic Motion of Helix A in the Amino-terminal Domain of Calmodulin is Stabilized Upon Calcium Activation." Biochemistry 44(3):905-914. 
  • Chen B, MU Mayer, LM Markillie, DL Stenoien, and TC Squier. 2005. "Dynamic Motion of Helix A in the Amino-terminal Domain of Calmodulin is Stabilized Upon Calcium Activation." Biochemistry 44:905-914. 


  • Chen B, TC Squier, and DJ Bigelow. 2004. "Calcium Activation of the Ca-ATPase Enhances Conformational Heterogeneity Between Nucleotide Binding and Phosphorylation Domains ." Biochemistry 43(14):4366-4374. 


  • Chen B, and DJ Bigelow. 2002. "Phosphorylation Induces a Conformational Transition near the Lipid-Water Interface of Phospholamban Reconstituted with the Ca-ATPase ." Biochemistry 41(47):13965-13972. 

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