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Understanding Cellular Machinery through X-Ray Imaging

Friday, February 17, 2012: 10:00 AM-11:30 AM, Room 208-209 (VCC West Building)

What does the world of viruses, bacteria, and cells look like? For years, our understanding of the structure and function of these biological systems has been transformed by a single technology: protein crystallography. In this technique, proteins are removed from their environment, crystallized, and interrogated by X-rays to obtain their static structure. With new imaging technologies, scientists can obtain sharp, clear images of living, dynamic structures in their native environments. X-ray tools are opening frontiers in understanding the reactions happening inside cells by understanding cellular life. This symposium will explore three tools that open vistas, allowing direct visualization and quantitative analysis of the cellular machinery. These technologies bring, tantalizingly close, the possibilities of imaging individual biological molecules that are too small to study, even with the most powerful microscopes.


Louis J. Terminello, Chief Scientist for the Fundamental & Computational Science Directorate, Pacific Northwest National Laboratory


Anton Barty, Center for Free-Electron Laser Science
Imaging and Nanocrystallography of Biological Objects with X-Ray Free-Electron Lasers

Carolyn Larabell, Lawrence Berkeley National Laboratory
X-Ray Microscopy and the View Inside Living Cells

Chris Jacobsen, Advanced Photon Source
X-Ray Microscopy in Color: 3D Views of Cellular Chemistry




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